Background: Activation of nuclear factor (NF)-kappaB has been shown to play a critical role in the pathogenesis of ulcerative colitis (UC). The purpose of the current study was to investigate the effects of NF-kappaB decoy oligonucleotides (ODNs) on an experimental model of UC.
Methods: NF-kappaB decoy ODNs were administered in experimental colitis induced by dextran sulfate sodium (DSS).