Publications by authors named "Lan Lu"

Drought-induced changes in lakes and wetlands, crucial habitats for migratory waterbirds, can greatly affect their foraging and habitat utilization. These changes lead to a decline in waterbird species richness and may cause shifts in community assembly from phylogenetic and functional trait perspectives. However, a gap remains between ecological mechanistic research about these changes and conservation applications.

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Magnetic Resonance Fingerprinting (MRF) can be accelerated with simultaneous multislice (SMS) imaging for joint T and T quantification. However, the high inter-slice and in-plane acceleration in SMS-MRF causes severe aliasing artifacts, limiting the multiband (MB) factors to typically 2 or 3. Deep learning has demonstrated superior performance compared to the conventional dictionary matching approach for single-slice MRF, but its effectiveness in SMS-MRF remains unexplored.

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Lupalbigenin () is an antibacterial isoflavone isolated from (Lour.) Corner (Moraceae). In this study, we achieved the first gram-scale synthesis of lupalbigenin () from commercially available genistein (), with a yield of 47.

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  • Rectal neuroendocrine neoplasms (rNENs) are common and challenging to manage, with tumor size being a key predictor of disease progression; however, the genetic changes in rNENs during their advancement are not well understood.
  • A study analyzed 54 pairs of rNEN tumors and normal tissues and found significant differences in mutations between small (≤2 cm) and large (>2 cm) tumors, with specific driver genes and pathways more prevalent in larger tumors, particularly those with lymph node metastases.
  • The research highlights defective DNA repair processes in larger rNENs with metastases, and most patients had genetic alterations that could inform targeted treatments, advancing the understanding of rNEN genetics and
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River-lake confluences are key zones in the river-lake network, essential for managing contaminant transport and transformation. However, the role of biogeochemical transformations, particularly in phosphorus (P) dynamics, has been underexplored. As a result, this study looks into the dynamics of microbial communities and how important microbes are to the cycling of P.

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  • * A newly developed split-ring resonator (SRR) improves spatial precision of microwave signals, allowing targeted inhibition of neuronal activity within 1 mm of its gap.
  • * Experiments demonstrate that this microwave SRR can reduce seizure activity safely in both lab models and living subjects, confirming its biosafety.
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The passive sensing and active control of electromagnetic (EM) waves have always been attractive in electronic and information areas, especially during the intelligent era. Here a new method is presented to achieve the angle sensing of incident wave and adaptive control of backward scattering using the intelligent metasurface. The proposed unit cells have the ability to dynamically manipulate the receiving and reflection of the EM energy respectively.

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Background: Myo-inositol (MI) and D-chiro-inositol (DCI) are two paramount isomers of inositol, both vital in glucose and steroid metabolism. Deficits in MI, DCI or MI/DCI ratio are expressly concerned with several pathological process, whereas MI and DCI lack practical measurement for human specimen.

Methods: To quantify MI and DCI in serum samples simultaneously, a gas chromatography tandem mass spectrometry (GC-MS/MS) method was established.

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Background: Blended teaching is an effective approach that combines online and offline teaching methods, leading to improved outcomes in medical education compared to traditional offline teaching. In this study, we examined the impact of blended teaching in clinical skills training, a medical practice course.

Methods: This study involved forty-eight undergraduate students studying clinical medicine in the fifth semester at Wuhan University of Science and Technology.

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Liver cancer is a heterogeneous disease characterized by poor responses to standard therapies and therefore unfavourable clinical outcomes. Understanding the characteristics of liver cancer and developing novel therapeutic strategies are imperative. Ferroptosis, a type of programmed cell death induced by lipid peroxidation, has emerged as a potential target for treatment.

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  • The study examines the effectiveness of a combined eye surgery (phacoemulsification, goniosynechialysis, and goniotomy) for treating primary angle closure glaucoma in patients with cataracts, noting that success is not influenced by the severity of peripheral anterior synechiae.
  • It involved 304 eyes from 283 patients over around 12.5 months, showing a significant reduction in intraocular pressure (IOP) post-surgery across all severity groups, with no notable differences in success rates.
  • Although more severe peripheral anterior synechiae (270°≤PAS<360°) experienced increased instances of complications like hyphema, the overall results indicated that the combined procedure is effective regardless of PAS extent
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Microplastic (MP) residues in marine have become an increasingly serious environmental pollution issue, and in recent years the detection of MPs in marine started to attract worldwide research interests. Optical-fiber-based environmental sensors have been extensively employed for their several merits such as high sensitivity, pressure resistance, compactness and ease of constructing communication networks. However, fiber-optic refractive index sensors are not specifically developed for distinguishing MPs from other inorganic particles suspended in water.

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  • The study examines how dissolved black carbon (DBC) interacts with contaminants and how UV radiation affects its stability in water.
  • It involves extracting dissolved biochars from wheat straw and analyzing their behavior under various water conditions and after UV exposure.
  • Results show a notable reduction in the stability of biochars under radiation, highlighting significant changes in their surface properties and aggregation, suggesting a three-stage mechanism influenced by UV exposure.
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Extracellular polymeric substances (EPS) constitutes crucial elements within bacterial biofilms, facilitating accelerated antimicrobial resistance and conferring defense against the host's immune cells. Developing precise and effective antibiofilm approaches and strategies, tailored to the specific characteristics of EPS composition, can offer valuable insights for the creation of novel antimicrobial drugs. This, in turn, holds the potential to mitigate the alarming issue of bacterial drug resistance.

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X-ray radiation information storage, characterized by its ability to detect radiation with delayed readings, shows great promise in enabling reliable and readily accessible X-ray imaging and dosimetry in situations where conventional detectors may not be feasible. However, the lack of specific strategies to enhance the memory capability dramatically hampers its further development. Here, we present an effective anion substitution strategy to enhance the storage capability of NaLuF:Tb nanocrystals attributed to the increased concentration of trapping centers under X-ray irradiation.

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Objective: Protein disulfide isomerase A3 (PDIA3) promotes the correct folding of newly synthesized glycoproteins in the endoplasmic reticulum. PDIA3 is overexpressed in most tumors, and it may become a biomarker of cancer prognosis and immunotherapy. Our study aims to detect the expression level of PDIA3 in gastric cancer (GC) and its association with GC development as wells as the underlying mechanisms.

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Unlabelled: Tuberculosis is the leading cause of death due to an infectious disease worldwide. Innate lymphoid type 3 cells (ILC3s) mediate early protection during () infection. However, the early signaling mechanisms that govern ILC3 activation or recruitment within the lung during infection are unclear.

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Purpose: To investigate the effectiveness and safety of phacogoniotomy versus phacotrabeculectomy (PVP) among patients with advanced primary angle-closure glaucoma (PACG) and cataracts.

Design: Multicenter, randomized controlled, non-inferiority trial.

Methods: A total of 124 patients (124 eyes) with advanced PACG and cataracts were enrolled, with 65 in the phacogoniotomy group and 59 in the phacotrabeculectomy group.

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Active food packaging with controlled release behavior of volatile antimicrobials is highly desirable for enhancing the quality of fresh produce. In this study, humidity-responsive antimicrobial aerogels were developed using chitosan and dialdehyde nanocellulose, loading with cyclodextrin-cinnamaldehyde inclusion complexes (ICs) for achieving humidity-triggered release of the encapsulated antimicrobial agent. Results showed that the prepared aerogels had capable water absorption ability, which could be served as absorbent pads to take in excessive exudate from packaged fresh produce.

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  • Tracking nitrogen pollution sources is essential for managing water quality but is complicated due to varied contamination scenarios in freshwater systems.
  • In this study, the Soil and Water Assessment Tool (SWAT) and a pollution source database were used to classify sub-basins of the Liuyang River watershed based on their main nitrogen pollution sources.
  • A Random Forest model was developed to predict pollution sources using various data types, with the best accuracy achieved by combining taxonomic and functional metagenomic data, highlighting key bacterial species as important indicators of pollution.
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  • The study explores how different surface functional groups on polystyrene nanoplastics (PSNPs) affect their aggregation in aquatic environments, influenced by electrolytes like NaCl and proteins such as bovine serum albumin (BSA).
  • The presence of BSA significantly alters the critical coagulation concentration (CCC) of PSNPs, reducing it for non-modified particles while slightly increasing it for carboxyl-modified particles, showcasing the impact of BSA on aggregation mechanisms.
  • The order in which BSA and NaCl are introduced affects PSNP aggregation, particularly for certain modified particles, highlighting how environmental factors can influence the behavior of nanoplastics in water.
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Antimicrobial resistance (AMR) emerges as a severe crisis to public health and requires global action. The occurrence of bacterial pathogens with multi-drug resistance appeals to exploring alternative therapeutic strategies. Antivirulence treatment has been a positive substitute in seeking to circumvent AMR, which aims to target virulence factors directly to combat bacterial infections.

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Objective: To investigate the impact of coronavirus disease 2019 (COVID-19) specified preventive and control measures on the distribution and resistance transition of () in uninfected hospitalized patients during the pandemic.

Methods: This retrospective study retrieved data from 316 isolates in the year pre-COVID-19 (n=131) pandemic and the year under COVID-19 specified preventive and control (post-pandemic year, n=185), compared the general characteristics, laboratory results, and antimicrobial susceptibility tests of between the two groups.

Results: Compared with the pre-pandemic year, the isolation rate of (14.

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Smoking is a serious global health issue. Cigarette smoking contains over 7000 different chemicals. The main harmful components include nicotine, acrolein, aromatic hydrocarbons and heavy metals, which play the key role for cigarette-induced inflammation and carcinogenesis.

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Comprehending the response of microbial communities in rivers along urbanization gradients to hydrologic characteristics and pollution sources is critical for effective watershed management. However, the effects of complex factors on riverine microbial communities remain poorly understood. Thus, we established a bacteria-based index of biotic integrity (Ba-IBI) to evaluate the microbial community heterogeneity of rivers along an urbanization gradient.

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