Publications by authors named "Lan Hai-Nan"
JAK2-STAT5 signaling is insensitive to porcine growth hormone (pGH) in hepatocytes of neonatal pig.
Anim Cells Syst (Seoul)
April 2020
Article Synopsis
- Porcine growth hormone (pGH) plays a crucial role in the growth of pigs, but neonatal pigs are found to be insensitive to its effects, and the reasons for this are not completely understood.
- This study investigates the intracellular signaling pathways in neonatal pig hepatocytes, focusing on the JAK2-STAT signaling pathway, which was found to be inactive in response to pGH.
- The research suggests that negative regulatory molecules may be influencing this lack of signaling, explaining why growth in neonatal pigs does not depend on growth hormone, unlike in older pigs.
Cellular internalization and trafficking of 20 KDa human growth hormone.
Gen Comp Endocrinol
January 2019
Twenty kilodalton human growth hormone (20K-GH) is the second most abundant GH isoform after the twenty-two kilodalton human growth hormone (22 K-GH) isoform. 20K-GH exhibits similar but not identical physiological activities as that of 22K-GH. The cell behaviour of 22K-GH has been extensively studied, but little or no information has been reported regarding 20K-GH.
View Article and Find Full Text PDFB-32 is one of a panel of monoclonal anti-idiotypic antibodies to growth hormone (GH) that we developed. To characterize and identify its potential role as a novel growth hormone receptor (GHR) agonist, we determined that B-32 behaved as a typical Ab2β based on a series of enzyme-linked immunosorbent assay assays. The results of fluorescence-activated cell sorting, indirect immunofluorescence and competitive receptor binding assays demonstrated that B-32 specifically binds to the GHR expressed on target cells.
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