Responses of soil respiration and its temperature sensitivity to nitrogen and phosphorus depositions in a riparian zone.

Nitrogen and phosphorus depositions and global warming have continuously intensified, impacting soil respiration. However, the response mechanisms of soil respiration rate (R) and its temperature sensitivity (Q) to nitrogen and phosphorus depositions are still unclear, especially for riparian zones. Intact Fluvisols were collected at different water-level elevations (150, 160, 170, and 180 m) of the riparian zone of the Three Gorges Reservoir, China and incubated under 20 and 30 °C with additions of nitrogen (36 kg N ha yr), phosphorus (0.

FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models.

Background: We developed the FORCE platform to overcome limitations of oligonucleotide delivery to muscle and enable their applicability to neuromuscular disorders. The platform consists of an antigen-binding fragment, highly specific for the human transferrin receptor 1 (TfR1), conjugated to an oligonucleotide via a cleavable valine-citrulline linker. Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by expanded CUG triplets in the DMPK RNA, which sequester splicing proteins in the nucleus, lead to spliceopathy, and drive disease progression.

Causal analysis for multivariate integrated clinical and environmental exposures data.

Electronic health records (EHRs) provide a rich source of observational patient data that can be explored to infer underlying causal relationships. These causal relationships can be applied to augment medical decision-making or suggest hypotheses for healthcare research. In this study, we explored a large-scale EHR dataset on patients with asthma or related conditions (N = 14,937).

Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review.

Cerebral ischemia-reperfusion injury (CIRI) is clinically characterized by high rates of morbidity, disability, mortality, and recurrence as well as high economic burden. The clinical manifestations of CIRI are often accompanied by gastrointestinal symptoms such as intestinal bacterial dysbiosis and gastrointestinal bleeding. Gut microbiota plays an important role in the pathogenesis of CIRI, and its potential biological effects have received extensive attention.

Variation of genes in the blast fungus from Jiangxi Province, China.

The avirulence (AVR) genes of Magnaporthe oryzae are pivotal in eliciting resistance responses in rice, which are mediated by resistance (R) genes in rice. Monitoring the variation of AVR genes in the pathogen is essential for strategically deploying R genes in rice cultivation regions. In this study, a total of 214 isolates were collected from Jiangxi Province, China, in 2022, and the distribution and variation of AVR genes in these isolates were analyzed by PCR amplification and sequencing.

[Effect of minimally invasive circumferential resection on inflammatory response and alveolar crest resorption in patients with dental defect implantation].

Purpose: To explore the impact of minimally invasive circumferential resection on inflammatory response and alveolar crest resorption in patients with dental defect implantation.

Methods: A total of 198 patients who received dental implantation in Lishui Hospital of Traditional Chinese Medicine from June 2021 to June 2023 were selected and divided into minimally invasive group (n=100) and traditional group (n=98) according to treatment methods. Minimally invasive surgery was performed in the minimally invasive group and traditional flap surgery was performed in the traditional group.

Plant conservation in the age of genome editing: opportunities and challenges.

Numerous plant taxa are threatened by habitat destruction or overexploitation. To overcome these threats, new methods are urgently needed for rescuing threatened and endangered plant species. Here, we review the genetic consequences of threats to species populations.

Inetetamab-based therapy in real-world treatment patterns with HER2-positive advanced breast cancer patients: a retrospective single-center study.

Background: Inetetamab is a novel antibody targeting human epidermal growth factor receptor 2 (HER2) developed in China. Due to its optimized antibody-dependent cell-mediated cytotoxicity effect compared with trastuzumab, it has shown good efficacy and safety in the treatment of HER2-positive advanced breast cancer (ABC).

Objectives: This study aimed to investigate the efficacy and safety of inetetamab combination therapy in the treatment of HER2-positive ABC in real-world clinical practice.

Questionnaire survey and analysis of drug clinical research implementation capabilities of breast cancer treatment departments in Chinese hospitals.

Background: Clinical research competence determines the quality of clinical research and the reliability of research findings. We aimed to explore the clinical research implementation capabilities of breast cancer treatment departments in China.

Methods: This was a department-based cross-sectional study conducted in the form of electronic questionnaires on the Wenjuanxing platform from 7th August to 31 August 2023 among hospitals from the first batch of breast cancer standardized diagnosis and treatment quality control pilot centers in China.

Efficacy and safety of first-line regimens for advanced HER2-positive breast cancer: A Bayesian network meta-analysis.

Background: The current standard of care for advanced human epidermal growth factor receptor 2 (HER2)-positive breast cancer is pertuzumab plus trastuzumab and docetaxel as first-line therapy. However, with the development of newer treatment regimens, there is a lack of evidence regarding which is the optimal treatment strategy. The aim of this network meta-analysis was to evaluate the efficacy and safety of first-line regimens for advanced HER2-positive breast cancer by indirect comparisons.

Virulent isolates with diverse morphologies show similar invasion and colonization strategies in alfalfa.

Root rot is a major disease that causes decline of alfalfa production, and is a major pathogen associated with root rot. In this study, 13 isolates were obtained from alfalfa with root rot in Gansu Province, the major alfalfa production region in China. The isolates were characterized by molecular genotyping (, and fragments) and identified as six species, which included the , , , , , and .

A model-based sliding mode control with intelligent distribution for a proportional valve driven by digital valve arrays.

Parallel-connected digital valve arrays are commonly utilized in the pilot stage of the proportional directional valve to enhance dynamic performance and reliability. However, when the digital valve array is driven by a digital signal, it is difficult to optimally assign the signal pulses to each valve. If the assignment is not well executed, it can significantly reduce the switching uniformity of the digital valves or lead to performance degradation of the system.

Ultrasonic backscattering model for Rayleigh waves in polycrystals with Born and independent scattering approximations.

This paper presents theoretical and numerical models for the backscattering of 2D Rayleigh waves in single-phase, untextured polycrystalline materials with statistically equiaxed grains. The theoretical model, based on our prior inclusion-induced Rayleigh wave scattering model and the independent scattering approximation, considers single scattering of Rayleigh-to-Rayleigh (R-R) waves. The numerical finite element model is established to accurately simulate the scattering problem and evaluate the theoretical model.

Complete genome sequence of ARqua1.

We report the complete genome of ARqua1 generated from Oxford Nanopore and Illumina sequencing. The genome of ARqua1 has a total length of 5,714,310 bp, comprising a circular chromosome, a linear chromosome, and two plasmids. In total, 5,446 genes were predicted, of which 5,288 were annotated.

Shear Wave Ultrasound Inspection of Flaws in Silicon Wafers Using Focused Transducers.

Silicon parts can contain micrometer-sized vertical cracks that are challenging to detect. Inspection using high-frequency focused ultrasound has shown promise for detecting defects of this size and geometry. However, implementing focused ultrasound to inspect anisotropic media can prove challenging, given the directional dependence of wave propagation and subsequent focusing behavior.

Safety and efficacy study of oral metronomic capecitabine combined with pyrotinib in HER2-positive metastatic breast cancer: A phase II trial.

Purpose: To analyze the safety and efficacy of orally administered metronomic capecitabine plus pyrotinib in HER2 positive metastatic breast cancer (MBC) patients, we conducted a prospective phase II study with a single-arm design.

Methods: HER2 positive patients received oral metronomic capecitabine 500 mg three times a day and pyrotinib 400 mg per day. The primary endpoint was progression-free survival (PFS).

CDK4/6 inhibitors, PI3K/mTOR inhibitors, and HDAC inhibitors as second-line treatments for hormone receptor-positive, HER2-negative advanced breast cancer: a network meta-analysis.

Background: This study sought to compare the benefits and safety of agents including Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors, and histone deacetylase (HDAC) inhibitors as second-line treatments for these patients by conducting a comprehensive systematic review and network meta-analysis.

Methods: The Medline, Embase and Cochrane Library databases were searched for randomized trials comparing CDK4/6 inhibitors, PI3K/mTOR inhibitors, or HDAC inhibitors vs. placebo with the addition of exemestane or fulvestrant as second-line treatments in patients with HR + advanced breast cancer up to December 16, 2021.

Analysis and identification of ferroptosis-related genes in ulcerative colitis.

Background: Previous studies have shown that ferroptosis is associated with the pathogenesis of ulcerative colitis (UC). Therefore, this study aimed to identify key ferroptosis-related genes (FRGs) associated with the diagnosis of UC.

Methods: UC-related expression datasets were downloaded from the Gene Expression Omnibus (GEO) database.