Responses of soil respiration and its temperature sensitivity to nitrogen and phosphorus depositions in a riparian zone.

Nitrogen and phosphorus depositions and global warming have continuously intensified, impacting soil respiration. However, the response mechanisms of soil respiration rate (R) and its temperature sensitivity (Q) to nitrogen and phosphorus depositions are still unclear, especially for riparian zones. Intact Fluvisols were collected at different water-level elevations (150, 160, 170, and 180 m) of the riparian zone of the Three Gorges Reservoir, China and incubated under 20 and 30 °C with additions of nitrogen (36 kg N ha yr), phosphorus (0.

FORCE platform overcomes barriers of oligonucleotide delivery to muscle and corrects myotonic dystrophy features in preclinical models.

Background: We developed the FORCE platform to overcome limitations of oligonucleotide delivery to muscle and enable their applicability to neuromuscular disorders. The platform consists of an antigen-binding fragment, highly specific for the human transferrin receptor 1 (TfR1), conjugated to an oligonucleotide via a cleavable valine-citrulline linker. Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by expanded CUG triplets in the DMPK RNA, which sequester splicing proteins in the nucleus, lead to spliceopathy, and drive disease progression.

Comparison of various liver cancer staging systems in predicting prognosis after initial transcatheter arterial chemoembolization: a retrospective study from China.

Background: Hepatocellular carcinoma (HCC) constitutes approximately 75-85% of primary liver cancers and is a heavy burden on public health. Many innovative prediction systems have integrated radiomics, artificial intelligence, pathological information, or even genetic information for the stratification and prognosis prediction of patients with HCC. However, these systems still lack practical and clinical applications.

Causal analysis for multivariate integrated clinical and environmental exposures data.

Electronic health records (EHRs) provide a rich source of observational patient data that can be explored to infer underlying causal relationships. These causal relationships can be applied to augment medical decision-making or suggest hypotheses for healthcare research. In this study, we explored a large-scale EHR dataset on patients with asthma or related conditions (N = 14,937).

Novel Insight into the Modulatory Effect of Traditional Chinese Medicine on Cerebral Ischemia-Reperfusion Injury by Targeting Gut Microbiota: A Review.

Cerebral ischemia-reperfusion injury (CIRI) is clinically characterized by high rates of morbidity, disability, mortality, and recurrence as well as high economic burden. The clinical manifestations of CIRI are often accompanied by gastrointestinal symptoms such as intestinal bacterial dysbiosis and gastrointestinal bleeding. Gut microbiota plays an important role in the pathogenesis of CIRI, and its potential biological effects have received extensive attention.

High expression of nucleotide-binding oligomerization domain protein 1 correlates with poor prognosis and immune cell infiltration in Glioblastoma Multiforme patients.

Nucleotide-binding oligomerization domain protein 1 (NOD1) is one of the innate immune receptors that has been associated with tumorigenesis and abnormally expressed in various cancers. However, the role of NOD1 in Glioblastoma Multiforme (GBM) has not been investigated. We used the Tumor Immune Estimate Resource (TIMER) database to compare the differential expression of NOD1 in various tumors.

Unsymmetric triazine-based triglucoside detergents for membrane protein stability.

Membrane proteins play a crucial role in a variety of biological processes and are key targets for pharmaceutical development. Structural studies of membrane proteins provide molecular insights into the mechanisms of these processes and are essential for effective drug discovery. Historically, these studies have relied on solubilization of the target protein using detergents, but conventional detergents often fail to maintain the stability of challenging membrane proteins.

Thermostat-induced artificial lane formation in non-equilibrium molecular dynamics.

While most thermostats in molecular dynamics are designed for equilibrium systems, their extension to non-equilibrium simulations has little theoretical justification. In the literature, an artifact referred to as "lane formation" was discovered; however, its cause remained unclear and was simply attributed to a constraint on velocity fluctuations or non-ergodicity in thermostats. In addition, global deterministic thermostatted dynamics was found to exhibit unceasing phase-space compression in steady states, incompatible with their expected stationary distributions and Gibbs entropy, which was mistakenly perceived as inescapable.

Association between SOFA score and risk of acute kidney injury in patients with diabetic ketoacidosis: an analysis of the MIMIC-IV database.

Introduction: The Sequential Organ Failure Assessment (SOFA) score is a widely utilized clinical tool for evaluating the severity of organ failure in critically ill patients and assessing their condition and prognosis in the intensive care unit (ICU). Research has demonstrated that higher SOFA scores are associated with poorer outcomes in these patients. However, the predictive value of the SOFA score for acute kidney injury (AKI), a common complication of diabetic ketoacidosis (DKA), remains uncertain.

Partial cystectomy as a surgical option for colorectal cancer patients with pathological bladder invasion: an original retrospective study.

Background: Limited research exists on colorectal cancer (CRC) patients with bladder invasion, with survival outcomes post-cystectomy underexplored and a debate between partial and total cystectomy ongoing.

Objective: The study aimed to evaluate the effect of pathological bladder invasion on the long-term tumour prognosis of patients with clinically diagnosed bladder invasion in CRC after cystectomy.

Design: Retrospective, cohort study.

Isomerism Effect of 3D Dimeric Acceptors for Non-Halogenated Solvent-Processed Organic Solar Cells with 20 % Efficiency.

Organic photovoltaic materials that can be processed via non-halogenated solvents are crucial for the large-area manufacturing of organic solar cells (OSCs). However, the limited available of electron acceptors with adequate solubility and favorable molecular packing presents a challenge in achieving efficient non-halogenated solvent-processed OSCs. Herein, inspired by the three-dimensional dimeric acceptor CH8-4, we employed a molecular isomerization strategy to synthesize its isomers, CH8-4A and CH8-4B, by tuning the position of fluorine (F) atom in the central unit.

Enhanced electron transfer for the improvement of nitrogen removal efficiency and NO reduction at low temperatures.

Low temperature generally restricts biological activity, slowing down electron transfer in biogeochemical cycles and causing a series of environmental problems such as nitrogen pollution. We present a strategy to boost electron transfer in microbial cell at low temperatures via stimulation with low current. It is demonstrated by establishing a constructed wetland system coupled with solar powered microbial electrolysis cell, which enhances microbial activity through external micro currents (18.

F-FAPI-42 PET/CT enhances the diagnostic efficacy for peritoneal metastasis of colorectal cancer and guides treatment decisions: an original retrospective study.

Background: Colorectal cancer is the third-most common type of cancer. When peritoneal metastasis (PM) develops, diagnosing metastatic lesions is difficult and the prognosis is poor. This study aimed to compare the value of fluorine-18 fibroblast activation protein-specific inhibitor (F-FAPI-42) and fluorine-18 fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) for detecting PM of colorectal cancer and to guide clinical decision-making.

A Clinical Prediction Model For Short-Term Prognosis In Patients With Non Acute Myocardial Infarction Related Cardiogenic Shock.

Background: While acute myocardial infarction (AMI) is widely recognized as the primary cause of Cardiogenic Shock (CS), Non-AMI related CS has been excluded from the majority of CS studies. Information on its prognostic factors remains largely understudied, and it is necessary to focus on these patients to identify the specific risk factors. In this study, we aimed to build and validate a predictive nomogram and risk classification system.

Bifunctional BiSmFeO/g-CN Piezocatalyst for Simultaneous H and HO Production.

Piezocatalysis portrays a promising alternative for producing hydrogen (H) and hydrogen peroxide (HO) in a clean and safe way, but the simultaneous enhancement of both properties remains challenging. In this study, a BiFeO-based bifunctional piezocatalytic strategy via Sm doping and g-CN compositing (BiSmFeO/g-CN) was proposed for efficient simultaneous H and HO production. Benefiting from the synergistic effect between the optimized energy band structure and piezo-generated charges, the performances of hydrogen evolution reaction (HER) and water oxidation reaction (WOR) are both enhanced remarkably.

Variation of genes in the blast fungus from Jiangxi Province, China.

The avirulence (AVR) genes of Magnaporthe oryzae are pivotal in eliciting resistance responses in rice, which are mediated by resistance (R) genes in rice. Monitoring the variation of AVR genes in the pathogen is essential for strategically deploying R genes in rice cultivation regions. In this study, a total of 214 isolates were collected from Jiangxi Province, China, in 2022, and the distribution and variation of AVR genes in these isolates were analyzed by PCR amplification and sequencing.

Signature of immune-related metabolic genes predicts the prognosis of hepatocellular carcinoma.

Introduction: The majority of liver cancer cases (90%) are attributed to hepatocellular carcinoma (HCC), which exhibits significant heterogeneity and an unfavorable prognosis. Modulating the immune response and metabolic processes play a crucial role in both the prevention and treatment of HCC. However, there is still a lack of comprehensive understanding regarding the immune-related metabolic genes that can accurately reflect the prognosis of HCC.

Perioperative and Oncologic Outcomes of Hepatic Arterial Infusion (HAI) Pump Chemotherapy for Patients with Unresectable Colorectal Liver Metastases at an Expanding HAI Program.

Background: Hepatic arterial infusion (HAI) is an established treatment for patients with unresectable colorectal liver metastases (uCRLM). Until recently, HAI was only performed at a limited number of centers. We previously reported early outcomes suggesting that implementation of a new HAI program is safe and feasible.

MET amplification correlates with poor prognosis and immunotherapy response as a subtype of melanoma: a multicenter retrospective study.

Background: Mesenchymal epithelial transition factor (MET) variant is an independent prognostic factor for worse prognosis in patients with lung cancer or gastroesophageal adenocarcinoma. MET gene variants can be regarded as a subtype of melanoma but there is a lack of studies regarding the frequency of MET genetic alterations and the efficacy of immunotherapy in melanoma patients. The purpose of this study is to explore potential therapeutic strategies for melanoma subtypes with MET alterations.

[Effect of minimally invasive circumferential resection on inflammatory response and alveolar crest resorption in patients with dental defect implantation].

Purpose: To explore the impact of minimally invasive circumferential resection on inflammatory response and alveolar crest resorption in patients with dental defect implantation.

Methods: A total of 198 patients who received dental implantation in Lishui Hospital of Traditional Chinese Medicine from June 2021 to June 2023 were selected and divided into minimally invasive group (n=100) and traditional group (n=98) according to treatment methods. Minimally invasive surgery was performed in the minimally invasive group and traditional flap surgery was performed in the traditional group.

EZH2 inhibition or genetic ablation suppresses cyst growth in autosomal dominant polycystic kidney disease.

Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a prevalent genetic disorder characterized by the formation of renal cysts leading to kidney failure. Despite known genetic underpinnings, the variability in disease progression suggests additional regulatory layers, including epigenetic modifications.

Methods: We utilized various ADPKD models, including Pkd1 and Ezh2 conditional knockout (Pkd1:Ezh2) mice, to explore the role of Enhancer of Zeste Homolog 2 (EZH2) in cystogenesis.