Fluoroquinolones versus beta-lactam based regimens for the treatment of osteomyelitis: a meta-analysis of randomized controlled trials.

Study Design: A meta-analysis of randomized control trials.

Objective: To compare fluoroquinolones to beta-lactams for the treatment of osteomyelitis.

Summary Of Background Data: Treatment of osteomyelitis remains a real challenge in medicine necessitating the use of broad-spectrum antibiotics, because of the variety of the pathogens causing the infection and the fact that the infected bone may become necrotic and avascular, preventing systemic antibiotics from adequately penetrating to the infection site.