[Improved prognosis in Wilms' tumor due to adjuvant combination drug therapy].

78 children with Wilms' tumor stage I--IV diagnosed since 1960 are presented. There were two groups of patients: one group consisting of 35 patients which received adjuvant chemotherapy for 1 year, the other group consisting of 43 patients which received no chemotherapy. Surgical excision and irradiation was identical in both groups.

Ultrastructural, biochemical, and cell-culture studies of a presumed extraskeletal Ewing's sarcoma with special reference to differential diagnosis from neuroblastoma.

The history of a 6-year-old girl with a tumor originating from thoracic spine and finally becoming resistant to surgery, radio-, and chemotherapy is reported. Tumor-biopsy material was studied by light and electron microscopy, in cell culture, by acetylcholinesterase ultracytochemistry, and by quantitative catecholamine analysis and this led to the rejection of the initial diagnosis of a neuroblastoma. Light microscopy revealed a uniform population of undifferentiated cells incompletely lobulated by broad fibrovascular septa.

[Dedifferentiating intracerebral neuroblastoma resistant to x-ray and drug therapy -- a case report (author's transl)].

A new case of primary intracerebral neuroblastoma is reported. The patient, a 2 year old boy, was subjected to temporary successful craniotomy, postoperative irradiation and cytostatic therapy without any influence on the recurrence of the tumor. In contrast to the possible well-known maturation of neuroblastomas a dedifferentiating process occurred.

[Neuroblastoma study NBL79-society of pediatric oncology -- report after 1 year (author's transl)].

Within 1 year 74 children with neuroblastoma were registered, 30 patients with stage I-III (= 41%) and 44 with stage IV-metastatic disease (= 59%). An aggressive chemotherapy regimen employing Adriamycine, Cyclophosphamide, Vincristine, and Dacarbazine yielded 10/24 partial and 9/24 complete remissions after 9 weeks. 5/24 children were treated less than 9 weeks so far.

[Leucocyte number, differential count and sedimentation rate in 9 "classic" childhood infections. (author's transl)].

A retrospective analysis of absolute numbers in 802 white blood counts and 396 sedimentation rates of 407 children, admitted between 1973-78, with 9 "classic" infections was done and evaluated for diagnostic usefulness. As diagnostic meaningful it was found: Lymphocytosis in pertussis; lymphocytopenia and slight increased sedimentation rate in measles; nothing particular in mumps; slight increased sedimentation rate in chicken pox; increase in mononuclear cells, particularly atypical lymphocytes and sedimentation rate in infectious mononucleosis; leucocytopenia caused by neutrocytopenia and lymphocytopenia in exanthema subitum (roseola infantum); increased sedimentation rate in scarlet fever; lymphocytopenia and a high sedimentation rate in mycoplasma-pneumonia; leucocytopenia with lymphocytopenia in rubella.

[Hypomagnesemic coma during therapy of septicaemia in a patient with acute lymphoblastic leukemia. (author's transl)].

During induction therapy of acute lymphoblastic leukemia a 10 year old boy developed a hyperuremic nephropathy and subsequently a staphylococcal septicemia at the beginning of the 3. week. Specific treatment was started leading to severe hypomagnesemia and generalized seizures with coma for 30 hours, which finally responded to magnesium replacement.

[Composite filling materials in cell cultures].

Using cell cultures of human gingiva, the composites Nuva Fil, Vytol, and Estic microfil were studied in terms of tissue tolerance. While the cytotoxicity for nonpolymerized and polymerized Nuva Fil and Vytol was extremely low, multinuclear fibroblasts were observed with Estic microfil.

[Human gingiva in cell culture].

Human gingival cells, particularly epithelial cells of the gingiva, have rarely been cultured successfully. Indispensible are single-layered cell sheets which allow to observe certain cells of a cell layer over a longer period of time when testing drugs and materials. One possibility was described for the cultivatability of these highly specialized cells, the long-term culturing of which has seldom been successful.

[Neuroblastoma in children. Clinical staging and management (author's transl)].

Sixty-four children with neuroblastoma stage I to III c are presented. The coordinated management utilizing surgical excision, irradiation (2--5.000 rad) in stage II and III and multiagent chemotherapy is described.

[ALL therapy study 1971-1974 of the German working group for leukemia research and therapy in childhood: prognostic significance of initial features and different therapeutic modalities (author's transl)].

495 children and adolescents with acute lymphoblastic leukemia entered a non-randomized therapy study between January 1st, 1971, and December 31st, 1974. They were treated at 40 pediatric clinics in the Federal Republic of Germany according to the protocol of the Deutsche Arbeitsgemeinschaft für Leukämieforschung und -Behandlung im Kindesalter, which was closely adapted to the Memphis protocol VII. These patients were analyzed retrospectively, data of evaluation was July 31st, 1978.

Acute bone marrow necrosis caused by streptococcal infection.

An 8 year old boy with a furuncle on the dorsum of the right foot, high fever, severe pain in the right knee joint, slight hepatosplenomegaly, leukopenia and thrombocytopenia was admitted with the working diagnosis of acute leukemia. However, an abundance of necrotic cells, together with clusters of streptococci, could be demonstrated in the bone marrow aspirate. After antibiotic therapy the boy recovered completely.

[Non-Hodgkin's lymphoma in children: improved prognosis through aggressive multiple drug combination and irradiation (author's transl)].

From 1964-1975 43 children with non-Hodgkin's lymphoma (NHL) were treated. 60% of the patients had far advanced disease at diagnosis. Therapy before 1970 consisted of low dose irradiation to the primary and single agent chemotherapy; no C.