Health care resource utilization and costs among adult patients with hemophilia A on factor VIII prophylaxis: an administrative claims analysis.

Standard of care for bleed prevention in patients with severe congenital hemophilia A is continuous prophylaxis with factor VIII (FVIII), typically administered intravenously 2-3 times per week in the home setting. Nonfactor prophylaxis and gene therapy are emerging novel prophylaxis strategies for hemophilia A, and it is important to compare their health economics with that of FVIII prophylaxis. Current data on resource utilization and costs in the adult hemophilia A prophylaxis population are limited, and a structured approach to analyze annual costs in these patients using administrative claims data has not been previously reported.

Predictors of Acute Liver Failure in Patients With Acute Hepatitis A: An Analysis of the 2016-2018 San Diego County Hepatitis A Outbreak.

Background: Between 2016 and 2018, San Diego County experienced a hepatitis A outbreak with a historically high mortality rate (3.4%) that highlighted the need for early recognition of those at risk of developing acute liver failure (ALF).

Methods: A retrospective case series of adult hospitalized patients with acute hepatitis A.

Retrospective Study on National Institutes of Health Stroke Scale as a Predictor of Patient Recovery After Stroke.

Background: The National Institutes of Health Stroke Scale (NIHSS) was designed primarily as a research instrument and is used in clinical settings. Its use has not yet been examined as a predictor of patient functional outcomes and prognosis in a community hospital setting.

Objectives: The aim of this study was to determine the effectiveness of baseline NIHSS score in predicting patient functionality and disposition at discharge in a designated stroke center at a community hospital.

Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain.

Stem cell transplantation promises new hope for the treatment of stroke although significant questions remain about how the grafted cells elicit their effects. One hypothesis is that transplanted stem cells enhance endogenous repair mechanisms activated after cerebral ischaemia. Recognizing that bilateral reorganization of surviving circuits is associated with recovery after stroke, we investigated the ability of transplanted human neural progenitor cells to enhance this structural plasticity.

Prenatal screening for infectious diseases: an analysis of disparities and adherence to policy in California.

Objectives: Prenatal infectious diseases are a major cause of mortality and morbidity among newborns, but many are preventable with proper maternal screening and treatment. METHODS; Adherence to prenatal infectious disease screening guidelines and demographic factors that influence adherence were determined utilizing existing data on 1837 live births from 1999-2003.

Results: We found higher rates of testing for syphilis (94.