Publications by authors named "Lamisse H El-Qarra"
Article Synopsis
- A new low-molecular-weight gelator (LMWG) made from a modified amino acid and an aldehyde can incorporate different active pharmaceutical ingredients (APIs) in distinct ways.
- Basic APIs like propranolol and atropine can mix with the gelator before it forms a gel, while acidic APIs like naproxen and rosuvastatin disrupt its bonding and must be incorporated afterward.
- Atropine showed effective release properties and holds promise for use in treating conditions like myopia, indicating the potential for further research and development using these supramolecular gels.
Enantiomers of the low-molecular-weight gelator (LMWG) DBS-CONHNH, based on D- or L- 1,3 : 2,4-dibenzylidenesorbitol (DBS), were synthesised. Enantiomeric gels are equivalent, but when mixtures of enantiomers are used, although gels still form, they are weaker than homochiral gels. Nanoscale chirality is lost on adding even a small proportion of the opposite enantiomer - homochiral assembly underpins effective gelation.
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