A case of adnexal cutaneous leishmaniasis in Washington DC.

Purpose: To report a rare non-endemic case of Leishmania aethiopica in Washington DC.

Case Report: A 68-year-old female presented for a routine examination with a complaint of right upper eyelid lesions for the past 5 months. On examination, a cluster of elevated and erythematous lesions extending from the medial canthus to the brow area of the right eye were seen.

Atraumatic Delayed Orbital Hematoma Sixteen Years After Orbital Floor Fracture Repair With Porous Polyethylene Implant.

Porous alloplastic materials such as titanium mesh and porous polyethylene allow for the ingrowth of fibrovascular tissues into the implant; stabilizing the implant and reducing the risk of extrusion and extrusion-related complications (such as hematoma formation). The literature contains 2 specific reports of delayed atraumatic orbital hematomas occurring 8 months and 3 years after orbital floor reconstruction with porous polyethylene implants. In this study, an atraumatic orbital hematoma occurring 16 years after orbital floor reconstruction with a porous polyethylene implant was presented.

Antibiotic Prophylaxis in Orbital Fractures.

Purpose: To determine whether prophylactic antibiotic use in patients with orbital fracture prevent orbital infection.

Design: Retrospective cohort study.

Participants: All patients diagnosed with orbital fracture between January 1, 2008 and March 1, 2014 at The George Washington University Hospital and Clinics.

Intermittent acute angle closure glaucoma and chronic angle closure following topiramate use with plateau iris configuration.

This is a case report describing recurrent intermittent acute angle closure episodes in the setting of topiramate use in a female suffering from migraines. Despite laser peripheral iridotomy placement for the pupillary block component, and the discontinuation of topiramate, the acute angle closure did not resolve in the left eye with chronic angle closure and the patient required urgent trabeculectomy. The right eye responded to laser peripheral iridotomy immediately and further improved after the cessation of topiramate.

Influence of surgery simulator training on ophthalmology resident phacoemulsification performance.

Purpose: To determine whether the use of an eye-surgery simulator during ophthalmology residency training improves cataract surgery performance.

Setting: Department of Ophthalmology, Medical Faculty Associates, George Washington University, Washington, DC, USA.

Design: Comparative case series.

Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis.

Syndecan-1 (sdc-1) is a cell surface proteoglycan that mediates the interaction of cells with their matrix, influencing attachment, migration, and response to growth factors. In keratinocytes, loss of sdc-1 delays wound healing, reduces migration, and increases Transforming growth factor beta (TGFbeta) 1 expression. In this study we show that sdc-1 expression is significantly reduced in basal cell, squamous cell, and metastatic human skin cancers compared to normal human skin.