Resting-state brain connectivity changes in obese women after Roux-en-Y gastric bypass surgery: A longitudinal study.

Bariatric surgery is an effective method to rapidly induce weight loss in severely obese people, however its impact on brain functional connectivity after longer periods of follow-up is yet to be assessed. We investigated changes in connectivity in 16 severely obese women one month before, one month after and one year after Roux-en-Y gastric bypass surgery (RYGB). 12 lean controls were also enrolled.

A MIR4646 associated methylation locus is hypomethylated in adolescent depression.

Background: Studies of epigenetics and transcriptional activity in adolescents may provide knowledge about possible preventive strategies of depression.

Methods: We present a methylome-wide association study (MWAS) and cohort validation analysis of depression in adolescents, in two separate cohorts: discovery (n=93) and validation data set 1 (n=78). The genome-wide methylation pattern was measured from whole blood using the Illumina 450K array.