Pregnancy in a Patient with Spinal Muscular Atrophy and Severe Restrictive Lung Disease.

Spinal muscular atrophy (SMA) is a rare autosomal recessive neuromuscular disease that is often associated with chronic respiratory failure. Few cases have described the antepartum and postpartum course in patients with severely compromised respiratory status. We present a case of a 24-year-old nullipara with a history of SMA type II complicated by surgically corrected kyphoscoliosis and severe restrictive lung disease.

Prevalence of and Risk Factors for Emergency Department Visits After Outpatient Gynecologic Surgery.

Study Objective: To identify the prevalence of and risk factors for emergency department (ED) visits within 30 days of outpatient gynecologic surgery.

Design: Retrospective cohort study.

Setting: Tertiary academic medical institution.

Skin Incision Selection in Superobese Women Undergoing Cesarean Birth.

Objective: The aim of this study was to examine whether vertical versus transverse skin incision is associated with increased wound complications in superobese women undergoing cesarean.

Study Design: This is a secondary analysis of a retrospective cohort study that included women with a body mass index (BMI) ≥ 50 kg/m and a cesarean birth with documented skin incision type from 1/1/2008 to 12/31/2015 at a single academic medical center. The primary outcome was a composite of wound complications: infection requiring antibiotics including superficial cellulitis, deep and organ space infections requiring packing, vacuum placement or exploration and debridement in the operating room.

Conventional Laparoscopy Is the Better Option for Tubal Sterilization Reversal: A Closer Look at Tubal Reanastomosis.

Permanent sterilization is one of the most common methods of birth control in the United States and around the world. A small subset of women will regret their decision and desire future fertility. For these women, the options include fertilization (IVF) or surgical reversal.

Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation.

Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under various physiological and pathological conditions, including cancer dissemination. Yet, the exact signaling pathways leading to these effects remain unknown. In a pediatric malignancy, neuroblastoma (NB), high NPY release from tumor tissue associates with metastatic disease.

Nasopharyngeal Microbiome Diversity Changes over Time in Children with Asthma.

Background: The nasopharynx is a reservoir for pathogens associated with respiratory illnesses such as asthma. Next-generation sequencing (NGS) has been used to characterize the nasopharyngeal microbiome of infants and adults during health and disease; less is known, however, about the composition and temporal dynamics (i.e.