Complete Osseointegration of a Retrieved 3-D Printed Porous Titanium Cervical Cage.

Porous 3D-printed titanium has only recently been introduced for spinal applications. Evidence around its use is currently limited to animal studies and only few human case series. This study describes the histological findings of a retrieved EIT cervical cage, explanted 2 years after insertion.

Incorporation of morsellized bone graft under controlled loading conditions. A new animal model in the goat.

The aim of this study was to develop a new animal model in which we could assess the in vivo effects of mechanical stimuli in the incorporation process of impacted morsellized bone grafts. The subcutaneous pressure implant SPI was developed for use in the goat. This device can generate controlled loading conditions onto a fixed amount of bone graft in the distal femur.

Mechanical characteristics of impacted morsellised bone grafts used in revision of total hip arthroplasty.

The use of impacted, morsellised bone grafts has become popular in revision total hip arthroplasty (THA). The initial stability of the reconstruction and the effectiveness of any subsequent process of revitalisation and incorporation will depend on the mechanical integrity of the graft. Our aim in this study was to document the time-dependent mechanical properties of the morsellised graft.

Role of growth factors in the incorporation of unloaded bone allografts in the goat.

Revision of a failed total joint replacement often demands bone grafting methods to restore deficient bone stock. However, impaired allograft incorporation can be the result of inadequate host or graft properties. The stimulation of bone healing with growth factors could provide a new approach to deal with this problem.

Viability of the acetabular bone bed at revision surgery following cemented primary arthroplasty.

Loosening of total hip replacements is often associated with severe loss of periprosthetic bone. The notion exists that the remaining bone is sclerotic, avascular, and displays little osteogenic activity, and that it therefore potentially compromises the revitalization of bone grafts used to restore bony defects. To verify this opinion we studied the bone characteristics in acetabular bone biopsies taken at primary total hip arthroplasty (PTH) and revision total hip arthroplasty (RTH) for a cemented PTH.

The repeated sampling bone chamber: a new permanent titanium implant to study bone grafts in the goat.

We developed a repeated sampling bone chamber (RSBC) and tested its suitability for studying various aspects of the bone allograft incorporation process under reproducible nonload-bearing experimental conditions in a large vertebrate. Our chamber is made of commercially pure titanium and is designed to allow bone or tissue ingrowth into a removable hollow inner core. Three chambers per animal were randomly implanted in the tibias of 10 goats and were harvested every 8 weeks.

Impacted graft incorporation after cemented acetabular revision. Histological evaluation in 8 patients.

We took core biopsies from the acetabulum in 8 patients (at reoperation) after a previous revision with impacted cancellous allograft chips in combination with cement. Except for one biopsy specimen, the graft showed different stages of incorporation. In the specimens taken at 4 months, revascularization of the graft was found.