Oleanolic acid alleviating ischemia-reperfusion injury in rat severe steatotic liver via KEAP1/NRF2/ARE.

Severe steatosis in donor livers is contraindicated for transplantation due to the high risk of ischemia-reperfusion injury (IRI). Although Ho-1 gene-modified bone marrow mesenchymal stem cells (HO-1/BMMSCs) can mitigate IRI, the role of gut microbiota and metabolites in this protection remains unclear. This study aimed to explore how gut microbiota and metabolites contribute to HO-1/BMMSCs-mediated protection against IRI in severe steatotic livers.

Should the Baseline MRI Staging Criteria Differentiate Between Mucinous and Classical Rectal Adenocarcinoma?

Rationale And Objectives: To compare baseline MR imaging features for pre-treatment staging between rectal mucinous adenocarcinoma (RMAC) and rectal classical adenocarcinoma (RCAC), and to investigate whether the subtype of mucinous carcinoma influences MRI evaluation criteria and high-risk tumors identifying.

Methods: A total of 306 patients who underwent surgical rectal cancer resection were retrospectively reviewed in the study. MR imaging parameters of the primary tumor and lymph nodes (LNs) were compared between two subtypes.

Dual-modification strategy of Co(II) and g-CN to CuS for efficient colorimetric determination of thioglycolic acid in daily cosmetics.

A conventional colorimetric method based on CuS-catalyzed HO is improved by a dual-modification strategy and employed for thioglycolic acid (TGA) determination. The doping of Co(II) can enhance ion exchange efficiency. Meanwhile, the modification of g-CN can increase specific surface area and decrease unspecific aggregation.

Dual Application: p-CuS/n-ZnS Nanocomposite Construction for High-Efficiency Colorimetric Determination and Photocatalytic Degradation of Tetracycline in Water.

Herein, CuS was incorporated with ZnS to form a novel nanocomposite via cation exchange, and the product was then employed for dual application of the colorimetric determination and photocatalytic degradation of tetracycline (TC) in water. The formed p-n heterojunction provided an improved gap width and electron mobility, which could rapidly catalyze HO to produce plenty of •OH, supporting a color conversion with TMB. Meanwhile, the addition of TC could lead to the further enhancement in colorimetric signal, and the distinction level was sensitive to the target amount.

The Association of Outdoor Walking Per Week with Mental Health and Costs of Psychotropic Drugs in Adults.

Regular walking confers many physical health benefits, including a reduced risk of disease-specific and all-cause mortality and better physical fitness. However, less is known about its role in mental health. Thus, the aims of this study were to determine the associations of outdoor walking per week with costs of psychotropic drugs used and mental health in adults.

Mediating Effects of Adolescent Physical Activity, Self-Rated Health and Family Income.

Objective: To investigate and analyse the situation and relationship between adolescent physical activity and self-assessment of health to provide a reference for adolescent physical activity research.

Methods: A questionnaire was used to investigate the physical activity and self-rated health of 1,804 adolescents aged 14-18 years.

Results: There was a significant relationship between adolescents' physical activity and self-rated health.

Morphology Adjustment and Optimization of CuS as Enzyme Mimics for the High Efficient Colorimetric Determination of Cr(VI) in Water.

Metal sulfide is often utilized as a catalyzed material to form colorimetric response system for some heavy metal detection. While the aggregation effect and conventional morphology limited the catalyzed efficiency. Herein, a robust method based on morphology adjustment was proposed to improve the dispersibility and catalytic performance of CuS.

The Relationship Between Chinese College Student Offspring's Physical Activity and Father Physical Activity During COVID-19 Pandemic.

The purpose of this study was to evaluate the relationship between the physical activity of Chinese college students and the physical activity of their parents. This relationship was examined by linear regression. The results showed that (1) the physical activities of China's college students will be refurbished and used for the parents.

Genome-Wide Chromatin Structure Changes During Adipogenesis and Myogenesis.

The recently developed high-throughput chromatin conformation capture (Hi-C) technology enables us to explore the spatial architecture of genomes, which is increasingly considered an important regulator of gene expression. To investigate the changes in three-dimensional (3D) chromatin structure and its mediated gene expression during adipogenesis and myogenesis, we comprehensively mapped 3D chromatin organization for four cell types (3T3-L1 pre-adipocytes, 3T3-L1-D adipocytes, C2C12 myoblasts, and C2C12-D myotubes). We demonstrate that the dynamic spatial genome architecture affected gene expression during cell differentiation.

Identification of MET exon14 skipping by targeted DNA- and RNA-based next-generation sequencing in pulmonary sarcomatoid carcinomas.

Background: Pulmonary sarcomatoid carcinomas (PSCs) constitutes a heterogeneous group of NSCLCs, which show poor prognosis even with aggressive surgical treatment and postoperative chemotherapy. The detection MET exon14 skipping (METex14 skipping) in PSCs suggests the targeted therapeutic opportunities with MET TKIs.

Patients And Methods: We detected MET exon14 alterations using both targeted DNA- and RNA-based Next Generation Sequencing (NGS) and elucidated the driver mutation profile of 77 Chinese PSC patients.

Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways.

The central question in stem cell regulation is how the balance between self-renewal and differentiation is controlled at the molecular level. This study uses germline stem cells (GSCs) in the Drosophila ovary to demonstrate that the Drosophila CCR4 homolog Twin is required intrinsically to promote both GSC self-renewal and progeny differentiation. Twin/CCR4 is one of the two catalytic subunits in the highly conserved CCR4-NOT mRNA deadenylase complex.