The Spike Protein of SARS-coV2 19B (S) Clade Mirrors Critical Features of Viral Adaptation and Coevolution.

Pathogens including viruses evolve in tandem with diversity in their animal and human hosts. For , the focus is generally for understanding such coevolution on the virus spike protein, since it demonstrates high mutation rates compared to other genome regions, particularly in the receptor-binding domain (RBD). Viral sequences of the 19B (S) clade and variants of concern from different continents were investigated, with a focus on the A.