Immediate implant placement in molar regions: a 12-month prospective, randomized follow-up study.

Objectives: To evaluate marginal bone changes radiographically and clinically around immediately placed implants in molar regions associated with three bone regenerative techniques 12 months after loading.

Methods: Ninety-two patients received an implant after random allocation to a bone reconstruction method of remaining peri-implant bone defects using either Autologous bone (AB) chips, Ossix membrane (OM) or a combinations of AB chips and OM. After 4 months of healing, a re-entry surgery was performed to connect a healing abutment.

Immediate implant placement in molar regions: risk factors for early failure.

Objectives: To identify risk factors for early failure of immediately placed implants in molar regions associated with three bone regenerative techniques.

Methods: Ninety-two patients (44 women and 48 men; mean age 50 years, 35 smokers and 57 non-smokers) in need of a single implant crown to replace a molar were included. After placing the implant, patients were randomized to one of three treatment groups for bone reconstruction of remaining periimplant defects: Autologous bone (AB) chips, Ossix membrane (OM) or a combination of AB chips and OM.

The use of human hypertrophic chondrocytes-derived extracellular matrix for the treatment of critical-size calvarial defects.

Objectives: To evaluate the effect of immortalized hypertrophic chondrocytes extracellular matrix (HCM) with or without the use of guided bone regeneration (GBR) on the healing of critical-size calvarial defects.

Material And Methods: In 42 rats, 5 mm critical-size calvarial defects were surgically created. The animals were randomly allocated to six groups of seven rats each: Group A1: one defect was left untreated (control), while the contralateral defect was covered by a double non-resorbable membrane (GBR).

Fully vs. partially rough implants in maxillary sinus floor augmentation: a randomized-controlled clinical trial.

Objectives: To compare implants with a rough surface in their whole length (FR) with implants having a 2 mm coronal machined portion (PR) when used in association with a sinus-lift procedure.

Material And Methods: Twenty-six patients with 2 mm< or =x< or =9 mm residual alveolar crest were prosthetically restored with implants after a staged sinus-lift procedure using osteotomes. In 13 randomly chosen patients, no more than one FR implant was placed (test group), while the rest were PR implants.

The effect of enamel matrix proteins and deproteinized bovine bone mineral on heterotopic bone formation.

To evaluate the osteoinductive potential of deproteinized bovine bone mineral (DBBM) and an enamel matrix derivative (EMD) in the muscle of rats. Sixteen rats were used in this study. The animals were divided in three groups.

Interproximal papilla levels following early versus delayed placement of single-tooth implants: a controlled clinical trial.

Purpose: The aim of this study was to evaluate interproximal papillae and clinical crown height following the placement of single-tooth implants according to early and delayed protocols.

Materials And Methods: Forty-five patients were randomly allocated to either the "early" group or the "delayed" group. They were treated with a single-tooth acid-etched Osseotite implant in the maxillary or mandibular anterior or premolar region an average of 10 days (in the case of early placement) or 3 months (in the case of delayed placement) following tooth extraction.

Implant placement in bone formed beyond the skeletal envelope by means of guided tissue regeneration: an experimental study in the rat.

Objectives: The aim of the present study was to evaluate whether the placement of implants in bone formed by means of guided tissue regeneration (GTR) beyond the skeletal envelope may influence bone volume and/or structure.

Material And Methods: Rigid, hemispherical, Teflon capsules were placed with their open part facing the lateral surface of the ramus in both sides of the mandible in 18 rats. After 1 year, the capsules were removed by a re-entry operation, and a custom-made titanium implant was placed in the augmented ramus in only one side of the jaw.

Clinical and radiographic performance of delayed-immediate single-tooth implant placement associated with peri-implant bone defects. A 2-year prospective, controlled, randomized follow-up report.

Objectives: The aim of the present study was to compare the delayed-immediate (Im) and the delayed (De) protocols for placement of single-tooth implants.

Material And Methods: After allocation to the Im and De groups by random, 46 patients were treated with a single-tooth implant with acid etched surfaces (Osseotite) in the anterior or pre-molar region of the maxilla or the mandible on average 10 days (Im) or 3 months (De) following tooth extraction, respectively. Forty-one patients attended a follow-up visit 2 years after implant placement corresponding to 1(1/2) years of loading of the implant restorations.

Bone formation by enamel matrix proteins and xenografts: an experimental study in the rat ramus.

The aim of this study was to evaluate whether the use of enamel matrix proteins with or without the use of deproteinized bovine bone influences bone formation when used as an adjunct to guided bone regeneration (GBR). Twenty rats, divided into four groups of five animals each, were used in this study. Group A1: A hemispherical PTFE capsule was placed empty on the lateral aspect of the mandibular ramus (GBR).

Long-term stability of autogenous bone grafts following combined application with guided bone regeneration.

The aim of the study was to compare the long-term stability of membranous and endochondral autogenous bone grafts with or without combined application of guided bone regeneration (GBR). Twenty-five, male, 6-month old, albino rats were used in the study. The animals were divided into four groups (A5, A11, B5 and B11).

Patient experience of, and satisfaction with, delayed-immediate vs. delayed single-tooth implant placement.

Objectives: Recent investigations have focused on patients' subjective assessment of implant treatment. The aim of this study was to compare the patients' experience of surgical and prosthetic procedures, as well as satisfaction with function and aesthetics following single-tooth replacements mounted to early vs. delayed placed dental implants.

Susceptibility of GTR-regenerated periodontal attachment to ligature-induced periodontitis.

Aim: This study aimed to compare the susceptibility of guided tissue regeneration (GTR)-regenerated periodontal attachment to ligature-induced periodontitis with that of the pristine periodontium.

Methods: Periodontal breakdown was produced in four monkeys by the placement of orthodontic elastics around experimental teeth (test teeth). During a flap operation, the root surfaces were scaled and planed, and a notch indicating the apical termination of scaling and root planing was made in the root surface.

Fate of bone formed by guided tissue regeneration with or without grafting of Bio-Oss or Biogran. An experimental study in the rat.

Objectives: The aim of the study was to examine whether bone produced by guided tissue regeneration (GTR) in combination with Bio-Oss or Biogran is stable on a long-term basis.

Material And Methods: Fifty-four, 3-month-old Wistar rats were divided into three groups and rigid, hemispherical, teflon capsules were placed with their open part facing the lateral surface of the exposed mandibular ramus (one capsule per animal). In the first group, the capsules were loosely packed with a standardized quantity of Bio-Oss, in the second group with Biogran, and in the last group were left empty.

Effect of GBR in combination with deproteinized bovine bone mineral and/or enamel matrix proteins on the healing of critical-size defects.

Objectives: To evaluate the effect of guided bone regeneration (GBR) in combination with or without deproteinized bovine bone mineral (DBBM) and/or an enamel matrix derivative (EMD) on the healing of critical-size calvarial defects.

Material And Methods: Forty rats were used. In all animals, a standardized critical-size calvarial defect was created surgically.

Influence of demineralized bone matrix's embryonic origin on bone formation: an experimental study in rats.

Background: There are results suggesting that differences regarding bone-inducing potential, in terms of amount and/or rate of bone formation, exist between demineralized bone matrices (DBMs) of different embryonic origins.

Purpose: The aim of the present study was to examine whether the embryonic origin of DBM affects bone formation when used as an adjunct to guided tissue regeneration (GTR).

Materials And Methods: Endomembranous (EM) and endochondral (ECH) DBMs were produced from calvarial and long bones of rats, respectively.

Bone healing and soft tissue contour changes following single-tooth extraction: a clinical and radiographic 12-month prospective study.

Preservation of alveolar bone volume following tooth extraction facilitates subsequent placement of dental implants and leads to an improved esthetic and functional prosthodontic result. The aim of the present study was to assess bone formation in the alveolus and the contour changes of the alveolar process following tooth extraction. The tissue changes after removal of a premolar or molar in 46 patients were evaluated in a 12-month period by means of measurements on study casts, linear radiographic analyses, and subtraction radiography.

Deproteinized bovine bone (Bio-Oss) and bioactive glass (Biogran) arrest bone formation when used as an adjunct to guided tissue regeneration (GTR): an experimental study in the rat.

Objectives: Grafting of deproteinized bovine bone or bioactive glass has been suggested as an adjunct to guided tissue regeneration (GTR) for the treatment of periodontal and peri-implant bone defects but the influence of these materials on bone formation is not clarified. The aim of the study was to examine the long-term influence of deproteinized bovine bone (Bio-Oss) or bioactive glass (Biogran) on bone formation produced by GTR.

Material And Methods: Eighteen rats were used.

Bone healing following immediate versus delayed placement of titanium implants into extraction sockets: a prospective clinical study.

Purpose: The aim of this study was to compare bone healing and crestal bone changes following immediate (Im) versus delayed (De) placement of titanium dental implants with acid-etched surfaces (Osseotite) in extraction sockets.

Materials And Methods: Forty-six patients were randomly allocated to the Im or De group (n = 23 per group) and received 1 implant at the incisor, canine, or premolar region of the maxilla or the mandible. The implants were placed an average of 10 days following tooth extraction in the Im group and approximately 3 months after extraction in the De group.

Bone and suture regeneration in calvarial defects by e-PTFE-membranes and demineralized bone matrix and the impact on calvarial growth: an experimental study in the rat.

The aim of this study was to evaluate the effect of: guided tissue regeneration (GTR) alone, implantation of demineralized bone matrix (DBM) alone, and of the combined treatment on the healing of craniectomy defects involving the sagittal cranial suture, and to examine subsequent calvarial growth. Sixty four-week-old rats were used in the study. These animals were randomly assigned to five groups (A-E) of 12 animals.

Alveolar ridge augmentation using a resorbable copolymer membrane and autogenous bone grafts. An experimental study in the rat.

The aim of the present study was to compare the result of maxillary alveolar ridge augmentation by the combined use of mandibular bone grafts and resorbable membranes (Resolut), with that achieved by the use of the same type of bone graft combined with the placement of e-PTFE membranes (Gore-Tex). The experiment was carried out in 30 rats. In one side of the maxillary jaw, the edentulous alveolar ridge between the incisor and the first molar was augmented by means of an autogenous mandibular bone graft that was fixed with a titanium microimplant and covered with a resorbable membrane.

Augmentation of the rat jaw with autogeneic cortico-cancellous bone grafts and guided tissue regeneration.

The aim of the present study was to evaluate the effect of augmenting the maxillary alveolar ridge and the lateral aspect of the mandible with onlay autogeneic cortico-cancellous bone grafts that were covered with e-PTFE membranes. The experiment was carried out in 51 rats. In 15 rats, the edentulous maxillary jaw between the incisor and the first molar was augmented by means of an autogeneic ischiac bone graft that was fixed with a gold-coated microimplant.

Alveolar ridge augmentation by combining autogenous mandibular bone grafts and non-resorbable membranes.

The aim of the present study was to evaluate the effect of using mandibular cortical bone grafts covered with e-PTFE membranes for maxillary alveolar ridge augmentation, in comparison with the use of mandibular cortical grafts alone. The experiment was carried out in 20 rats. At one side of the maxillary jaw, the edentulous alveolar ridge between the incisor and the first molar was augmented by means of an autogenous mandibular bone graft, which was fixed with a titanium microimplant and covered with a Teflon membrane.

Augmentation of the mandible with GTR and onlay cortical bone grafting. An experimental study in the rat.

The aim of the present study was to evaluate the effect of augmenting the mandible with onlay mandibular bone grafts that were covered with e-PTFE membranes according to the principle of guided tissue regeneration (GTR). The experiment was carried out in 30 rats. The inferior border of the mandible and parts of the mandibular body were exposed on both sides.