Preinfection laboratory parameters may predict COVID-19 severity in tumor patients.

Background: Infection with SARS-CoV-2 leads to COVID-19, the course of which is highly variable and depends on numerous patient-specific risk factors. Patients with tumor diseases are considered to be more susceptible to severe COVID-19; however, they also represent a heterogeneous group of individuals with variable risk. Identifying specific risk factors for a severe course of COVID-19 in patients with cancer is of great importance.

Fusions in Wild-Type Pancreatic Cancer.

We used whole-genome and transcriptome sequencing to identify clinically actionable genomic alterations in young adults with pancreatic ductal adenocarcinoma (PDAC). Molecular characterization of 17 patients with PDAC enrolled in a precision oncology program revealed gene fusions amenable to pharmacologic inhibition by small-molecule tyrosine kinase inhibitors in all patients with wild-type () tumors (4 of 17). These alterations included recurrent rearrangements predicted to drive PDAC development through aberrant ERBB receptor-mediated signaling, and pharmacologic ERBB inhibition resulted in clinical improvement and remission of liver metastases in 2 patients with -rearranged tumors that had proved resistant to standard treatment.

Immune monitoring and TCR sequencing of CD4 T cells in a long term responsive patient with metastasized pancreatic ductal carcinoma treated with individualized, neoepitope-derived multipeptide vaccines: a case report.

Background: Cancer vaccines can effectively establish clinically relevant tumor immunity. Novel sequencing approaches rapidly identify the mutational fingerprint of tumors, thus allowing to generate personalized tumor vaccines within a few weeks from diagnosis. Here, we report the case of a 62-year-old patient receiving a four-peptide-vaccine targeting the two sole mutations of his pancreatic tumor, identified via exome sequencing.

Impact of SPARC expression on outcome in patients with advanced pancreatic cancer not receiving nab-paclitaxel: a pooled analysis from prospective clinical and translational trials.

Background: Conflicting results on the role of secreted protein acidic and rich in cysteins (SPARC) expression have been reported in resected pancreatic ductal adenocarcinoma (PDAC), and its prognostic and/or predictive role in advanced PDAC (aPDAC) has not been extensively investigated yet. This study was designed to evaluate SPARC expression as a biomarker in aPDAC patients (pts) not receiving nab-paclitaxel.

Methods: Using immunohistochemistry, we examined the stromal as well as the tumoral (i.

Development of a mirror-based endoscope for divertor spectroscopy on JET with the new ITER-like wall (invited).

A new endoscope with optimised divertor view has been developed in order to survey and monitor the emission of specific impurities such as tungsten and the remaining carbon as well as beryllium in the tungsten divertor of JET after the implementation of the ITER-like wall in 2011. The endoscope is a prototype for testing an ITER relevant design concept based on reflective optics only. It may be subject to high neutron fluxes as expected in ITER.

First results from the modular multi-channel dispersion interferometer at the TEXTOR tokamak.

At the TEXTOR tokamak in Jülich, Germany, a modular dispersion interferometer was installed and operated for the first time. Equipped with four lines of sight, the line-integrated density could be measured in parallel at different major radii with a resolution of better than 3 × 10(17) m(-2). This paper will describe the setup and show the first measurement results.

Improvement of coronary microvascular function after Angiotensin receptor blocker treatment with irbesartan in patients with systemic hypertension.

Patients with hypertension exhibit changes in vessel conductance and resistance. The aim of this study was to evaluate the effect of the angiotensin receptor blocker irbesartan on coronary microvascular function. Thirty-six hypertensive patients without coronary artery or systemic disease were examined.

Phase III trial of irinotecan plus infusional 5-fluorouracil/folinic acid versus irinotecan plus oxaliplatin as first-line treatment of advanced colorectal cancer.

Purpose: To determine whether irinotecan plus oxaliplatin (mIROX) is superior to irinotecan plus infusional 5-fluorouracil, leucovorin (FUFIRI) as first-line therapy of patients with metastatic colorectal cancer (mCRC).

Patients And Methods: A phase III, randomised, open-label multicentre study compared standard treatment with FUFIRI (irinotecan 80 mg/m(2), 5-fluorouracil 2000 mg/m(2), folinic acid 500 mg/m(2) weekly times 6) to mIROX using an identical schedule of irinotecan plus oxaliplatin 85 mg/m(2) applied on days 1, 15 and 29 of a 7-week cycle. The primary end-point was progression-free survival (PFS).

Development of a multichannel dispersion interferometer at TEXTOR.

The design and main characteristics of 14-channel dispersion interferometer for plasma profile measurement and control in TEXTOR tokamak are presented. The diagnostic is engineered on the basis of modular concept, the 10.6 microm CO(2) laser source and all optical and mechanical elements of each module are arranged in a compact housing.

Combining short stent implantation and drug-eluting stenting for routine use yields a low restenosis rate.

Background: The feasibility of using a single short bare metal stent (BMS) (less than 9 mm) in a high proportion of coronary artery lesions was shown in a previous study, which reported a low rate of restenosis. The present study aimed to investigate immediate and long-term results of a procedure that uses a single short BMS for all lesions that can be successfully treated with this method, and an implantation of a drug-eluting stent (DES) for all other lesions.

Methods: In a series of 200 consecutive patients, 236 coronary artery lesions were treated with either a short BMS (168 of 236 [71.

Combining short stent implantation and drug-eluting stenting for routine use yields a low restenosis rate.

Background: Stent length serves as a predictor of restenosis in use of bare metal stents (BMS). This has been demonstrated in a feasibility study that used a single short BMS implant (<9 mm) in a high proportion of lesions; the study observed a low rate of restenosis.

Methods: We performed a pilot prospective study to investigate in a series of consecutive patients the immediate and long-term effects of implantation of either 1) a single short BMS for all lesions with low probability of restenosis or 2) a drug-eluting stent (DES) for all other lesions.

Shortening the stent length reduces restenosis with bare metal stents: matched pair comparison of short stenting and conventional stenting.

Objective: To investigate the effect of reducing stent length on the rate of target lesion restenosis.

Design: In a prospective investigation, acute and long term results of a short stenting procedure were analysed by quantitative angiography and compared with results of a conventional stenting procedure selected according to a matched pairs analysis.

Patients: Short stents were implanted in 400 consecutive patients with 464 lesions and conventional stents in 430 patients.

Short stent implantation for routine use is feasible in a high proportion of coronary interventions and yields a low restenosis rate.

Stent length predicts restenosis. The feasibility of using a short stent (<10 mm) routinely was investigated in 331 consecutive patients treated for 424 coronary artery lesions. A single short stent provided suitable coverage and achieved a residual stenosis <30%, with or without predilatation, in 252/424 lesions (59.

[Non-invasive assessment of coronary flow reserve - valuable functional information in cardiac workflow].

Coronary flow reserve can be determined echocardiographically in the LAD in about 90 % and in the RCA in more than 80 % of patients respectively by the use of modern high-resolution ultrasound equipment. For this purpose either high frequency fundamental imaging or echo-contrast enhanced harmonic Doppler technology is used. The main advantage of the method lies in its noninvasiveness and the lack of radiation exposure.

Coronary artery flow reserve in diabetics with erectile dysfunction using sildenafil.

Background: Diabetics with erectile dysfunction have a high prevalence of microvascular disturbance of the coronary circuit as measured by coronary flow reserve (CFR).

Purpose: We aimed to evaluate the effects of the phosphodiesterase 5 inhibitor sildenafil on CFR in diabetics with erectile dysfunction.

Methods: Diabetics seeking diabetes refinement therapy were screened for vascular or neurogenic erectile dysfunction which was confirmed in 43 patients.

Validation of noninvasive assessment of coronary flow velocity reserve in the right coronary artery. A comparison of transthoracic echocardiographic results with intracoronary Doppler flow wire measurements.

Aims: Assessment of coronary flow velocity reserve (CFR) noninvasively using transthoracic Doppler echocardiography (TDE) is validated for the left anterior descending artery only. We evaluated the feasibility and reproducibility to assess CFR using TDE in the right coronary artery, and compared the results with intracoronary Doppler flow wire (DFW) measurements.

Methods And Results: Introduction of a modified apical 2-chamber view allows visualization of the posterior descending branch of the right coronary artery (RPD).

[Non-invasive assessment of coronary flow reserve--valuable functional information in cardiac workflow].

Coronary flow reserve (CFR) can be determined echocardiographically in the LAD in about 90% and in the RCA in more than 70% of patients, respectively, by the use of modern high-resolution ultrasound equipment. For this purpose either high frequency fundamental imaging or echo-contrast enhanced harmonic Doppler technology is used. The main advantage of the method lies in its noninvasiveness and the lack of radiation exposure.

Comparison of transthoracic Doppler echocardiography to intracoronary Doppler guidewire measurements for assessment of coronary flow reserve in the left anterior descending artery for detection of restenosis after coronary angioplasty.

Transthoracic Doppler echocardiography (TDE) has been described as a feasible and accurate technique to noninvasively assess coronary flow reserve (CFR) in the left anterior descending artery (LAD). This study was designed to evaluate whether serial assessment of CFR in the LAD using TDE allows detection of restenosis after previously performed angioplasty. Thirty-three consecutive patients with single-vessel coronary artery disease of the LAD scheduled for angioplasty underwent assessment of coronary flow velocity at rest and during adenosine-induced hyperemia in the distal LAD using high-frequency TDE.

[Sildenafil does not change coronary flow reserve in diabetics with erectile dysfunction].

Background And Aim Of Study: Disturbance of the microvascular coronary circuit is common in diabetics with erectile dysfunction. We investigated effects of sildenafil on coronary flow reserve (CFR) of the left anterior descending branch.

Patients And Methods: 43 diabetics (aged 59 +/- 7 years) with erectile dysfunction and without symptoms of coronary artery disease were selected.

Transthoracic echocardiographic visualization of coronary artery blood flow and assessment of coronary flow reserve in the right coronary artery: a first report of 3 patients.

Assessment of coronary flow reserve (CFR) has proven to be an important diagnostic tool providing useful clinical and physiologic information about coronary artery function. In several studies, the transthoracic echocardiographic assessment of CFR, defined as a ratio of hyperemic to basal coronary flow velocity, was validated in the left anterior descending artery. But so far, the visualization of coronary flow and the measurement of CFR were limited to the mid and distal portion of the left anterior descending artery.