Flunarizine Versus Propranolol in Prophylaxis of Pediatric Migraine: An Open-Label Randomized Trial.

Background Pediatric migraine is a primary headache affecting daily activities and causing significant disability among children. However, clarity on the usage of prophylactic medications in children is yet to be established. This study was conducted with the aim of comparing the efficacy and safety of flunarizine and propranolol in the prophylaxis of pediatric migraine.

Prostate cancer prognosis using machine learning: A critical review of survival analysis methods.

Prostate Cancer is a disease that affects the male reproductive system. The irregularity of the symptoms makes it hard for the clinicians to pinpoint the disease in the earlier stages. Techniques such as Machine Learning, Data Science, Deep Learning, etc.

The Impact of Yogic Breathing Exercises on Pulmonary Functions in Asymptomatic Smokers.

Introduction Smoking is a serious public health problem that leads to chronic obstructive pulmonary disease (COPD). Its harmful effects are more significantly seen in the respiratory system. Approximately 30% of smokers experience compromised lung functions.

Homoeopathic Treatment Of Psoriasis Using Fifty-Millesimal (LM) Potency: A Case Report.

Context: Psoriasis is a chronic, proliferative, and inflammatory skin disease related to the systemic manifestation of numerous organs. The typical lesion comprises red, scaly, sharply demarcated, indurated plaques, especially over the extensor surfaces and scalp. The degree and severity vary after some time and between people.

Lichen Planus Treated with Individualized Homeopathic Medicine, A Case Report.

Context: Lichen planus (LP) is a chronic lichenoid inflammatory disease of the skin, mucosa and appendages. The classic LP symptom is a dense infiltration of inflammatory T cells moving in the upper dermis and arranged in a band-like pattern. Lichen planus has an undetermined aetiology; however, it is known to have immune-mediated pathogenesis.

A Case Report of Alopecia Areata Treated With Individualized Homoeopathy.

Introduction: Hair is regarded as an essential part of human identity, and losing it has a negative effect on many facets of one's quality of life. Alopecia areata (AA) is a chronic, non-scarring hair loss of the scalp or body hair. It is believed to be an autoimmune disorder where the body cannot recognize its own cells, resulting in the subsequent destruction of the hair follicles.

A Case Report of Multiple Renal Calculi Treated With Individualized Homoeopathy.

Background: Mineral buildups called kidney stones can be free-floating or affixed to the renal papillae and occur in the renal calyces and pelvis. A major morbidity is associated with the widespread problem of renal stone disease. Open surgical lithotomy and minimally invasive endourological procedures are now the standard for the management of kidney stone symptoms.

Workplace Learning: Learning Experiences Of Pre-Clerkship Students In Their Clinical Learning Environment At A Medical University In UAE.

Objectives: To explore how studentsin the pre-clerkship phase perceive the workplace clinical learning environment based on their experiential learning and social participation.

Methods: The cross-sectional study was conducted at the Gulf Medical University, United Arab Emirates in June 2019 and comprised 2nd and 3rd year medical students. Data was collected using the undergraduate clinical education environment measure tool which is a valid and reliable instrument to measure clinical learning environment for undergraduate medical students.

Reduced Cholesterol Levels during Acute Human Babesiosis.

Background: Babesiosis, an intra-erythrocytic protozoan disease, is an emerging zoonotic parasitic disease worldwide. Cholesterol levels are correlated with severe infections, such as sepsis and COVID-19, and anecdotal reports suggest that high-density lipoprotein (HDL) cholesterol declines during acute babesiosis. Our aim was to describe the cholesterol levels in patients with acute babesiosis diagnosed in an endemic area in New York, hypothesizing that HDL levels correlate with the severity of infection.

False-Positive Serology for Rocky Mountain Spotted Fever in Long Island, New York, during 2011-2021.

Cases of rocky mountain spotted fever (RMSF) are increasingly reported every year in Long Island, New York. In clinical practice, an uncommonly high number of referrals with a positive RMSF IgG test result have been seen in our tick-borne disease clinic. The aim of this study is to describe the clinical-epidemiological characteristics and outcomes of hospitalized patients with positive serologies for RMSF in our academic center in Long Island, NY.

Specific and Sensitive Diagnosis of Babesia microti Active Infection Using Monoclonal Antibodies to the Immunodominant Antigen BmGPI12.

The apicomplexan pathogen Babesia microti is responsible for most cases of human babesiosis worldwide. The disease, which presents as a malaria-like illness, is potentially fatal in immunocompromised or elderly patients, making the need for its accurate and early diagnosis an urgent public health concern. B.

A Case Report of Tonsillolith Treated With Individualized Homoeopathy.

Introduction: Tonsillolith, also known as tonsil stones or tonsil calculi, are the mineralization of the debris or bacteria within the crevices of the palatine tonsils. It is a rare condition with prominent symptoms of halitosis (bad breath), foreign body sensation, sore throat, painful swallowing, and cough. So far, Individualized Homoeopathy for tonsillolith has been rarely recorded in peer-reviewed journals.

Recycling/reuse of plastic waste as construction material for sustainable development: a review.

The exponential rise in the production of plastic and the consequential surge in plastic waste have led the scientists and researchers look out for innovative and sustainable means to reuse/recycle the plastic waste in order to reduce its negative impact on environment. Construction material, converting waste plastic into fuel, household goods, fabric and clothing are some of the sectors where waste plastic is emerging as a viable option. Out of these, construction material modified with plastic waste has garnered lot of attention.

A Case Report of Alopecia Areata Treated with Individualized Homoeopathy.

Introduction: Alopecia areata is a dermatological disorder characterized by hair loss. The exact cause is still unknown but is linked with an autoimmune disease. No efficient treatment is known though many studies have been conducted, yet the optimal treatment is not known.

Polycystic Ovarian Syndrome Treated with Individualized Homeopathy: A Case Report.

Introduction: Polycystic ovarian syndrome (PCOS) is a polygenic, multifactorial, syndromic disorder with reproductive, endocrine, and metabolic dysfunction seen in reproductive aged women (12-45 years). The exact cause is not known may involve increased luteinizing hormone, increased insulin levels, and a defect in androgen synthesis. The symptoms include anovulation, irregular menses, and hyperandrogenism.

Acute postoperative endophthalmitis after resurgery following primary cataract surgery: 9 years experience from a tertiary eyecare center.

Purpose: To report the incidence, risk factors, and visual outcomes of acute postoperative endophthalmitis in patients undergoing resurgery after cataract surgery.

Setting: Tertiary eye hospital in southern India.

Design: Retrospective, clinical registry.

Virtual Clinical Encounter Examination (VICEE): A novel approach for assessing medical students' non-psychomotor clinical competency.

Introduction: The Corona Virus Disease-19 (COVID-19) pandemic disrupted medical education across the world. Online teaching has grown rapidly under lockdown. Yet the online approach for assessment presents a number of challenges, particularly when evaluating clinical competencies.

Early response to trazodone once-a-day in major depressive disorder: review of the clinical data and putative mechanism for faster onset of action.

Background: Most antidepressants have a delayed onset of action and must be administered for several weeks to generate therapeutic effects. Trazodone is a serotonin antagonist and reuptake inhibitor approved for the treatment of major depressive disorder. The once-a-day (OAD) formulation of trazodone has an improved tolerability profile compared to its conventional formulations.

Nephritic Syndrome.

Nephritic syndrome is a constellation of hematuria, proteinuria, hypertension, and in some cases acute kidney injury and fluid retention characteristic of acute glomerulonephritis. Infection-related glomerulonephritis, IgA nephropathy, lupus nephritis, membranoproliferative glomerulonephritis, and antineutrophil cytoplasmic antibody-associated vasculitis are the most common diseases in nephritic syndrome that primary care physicians might encounter in practice such that a solid comprehension of these can lead to earlier detection. This article describes the pathophysiology, incidence, clinical presentation, treatment, and disease progression of these nephritic syndrome entities, and provides guidance for when to refer to a nephrologist.

Neural Network Interactions Modulate CRY-Dependent Photoresponses in .

Light is one of the chief environmental cues that reset circadian clocks. In , CRYPTOCHROME (CRY) mediates acute photic resetting of circadian clocks by promoting the degradation of TIMELESS in a cell-autonomous manner. Thus, even circadian oscillators in peripheral organs can independently perceive light in However, there is substantial evidence for nonautonomous mechanisms of circadian photoreception in the brain.

Promoter-enhancer looping at the PPARγ2 locus during adipogenic differentiation requires the Prmt5 methyltransferase.

PPARγ2 is a critical lineage-determining transcription factor that is essential for adipogenic differentiation. Here we report characterization of the three-dimensional structure of the PPARγ2 locus after the onset of adipogenic differentiation and the mechanisms by which it forms. We identified a differentiation-dependent loop between the PPARγ2 promoter and an enhancer sequence 10 kb upstream that forms at the onset of PPARγ2 expression.