Genomic profiling reveals SMARCA4 mutations are associated with shorter overall and intracranial progression free survival in melanoma brain metastasis patients.

Purpose: Melanoma brain metastases (MBMs) are a common, lethal complication of metastatic melanoma. Despite improvements in treatments, subsets of MBM patients experience rapid decline, and few prognostic biomarkers have been identified. An improved understanding of the molecular features specifically associated with MBM overall survival (OS) and intracranial progression free survival (PFS) could facilitate the development of more effective clinical management strategies.

Measuring eating behavior and motivations in the United Arab Emirates and the United States: Evaluating measurement and predictive invariance of the Eating Disorder Examination Questionnaire-Short Form and the Eating Motivation Survey.

Considerable proportions of college students in White, educated, industrialized, rich, and democratic countries, such as the United States, suffer from eating disorders and other problematic eating behaviors. The prevalence of eating disorders in Western Asia has been historically low but is rapidly increasing. One of the most dramatic increases is occurring in the United Arab Emirates.

Green synthesis of silver nanoparticle for catalytic applications and priming study by seed germination.

Silver nanoparticles (AgNPs) have been successfully synthesized using leaf extract of Neem (Azadirachta Indica), Mint (Mentha Piperita), Tulsi (Ocimum Tenuiflorum), Bermuda grass (Cynodon Dactylon) and silver salt. As plant extracts produce best capping material for the stabilization of nanoparticles. AgNPs were characterized by UV-Vis spectroscopy in range of 200-800 nm and transmission electron microscopy TEM, XRD and FTIR.

Waste-Derived Copper Flakes for Solvent-Free Reductive Acetamidation of Nitroarenes.

Herein, waste-derived copper (Cu) flakes have been used as heterogeneous catalysts for the solvent-free and one-pot reductive acetamidation of nitroarenes. Metallic copper flakes (f-ZCu) were isolated from waste copper Cu scrap/flakes/turnings generated after the grinding and cutting (from the Cu industries). f-ZCu is being used to synthesize acetanilide with a considerable yield (∼82%) in one-step and solvent-free conditions within a reaction time of 6 h.

Fenton-mediated thermocatalytic conversion of CO to acetic acid by industrial waste-derived magnetite nanoparticles.

Iron oxide dust, discarded as industrial waste, has been used here to fabricate magnetic iron oxide nanoparticles (FeO-NPs). We have proposed the thermo-catalytic reduction of carbon dioxide (CO) using FeO-NPs in the presence of HO to get acetic acid (AcOH) at near ambient conditions (100 °C, 10 bar) with a maximum yield of ∼0.4 M in a batch-reactor.

Journey Towards a Meaningful Life: Adaptation and Resilience in the Lives of Young Hindu Widows.

Spousal death is a life-altering and traumatic life event in married life, compelling the surviving partner to transition and make substantial adjustments to their new life situation. Losing a spouse can affect individuals differently based on gender, impacting their psychological, social, and economic well-being. This article describes adaptation to a new life condition as widows strive to reconcile their roles, status, and identity while binding their resilience to direct their lives.

Comparative study of NiO/CuO/Ag doped graphene based materials for reduction of nitroaromatic compounds and degradation of dye with statistical study.

In the present work, the Nickel oxide (rGO-NiO), Silver (rGO-Ag), Copper oxide (rGO-CuO) doped Graphene Oxide are reported for catalytic reactions. A comparative study for catalytic activities of these materials are performed with nitroaromatic compound 4-nitroaniline and the results are statistically studied by using univariate analysis of variance and Post Hoc Test through Statistical Package for Social Sciences and it is observed that CuO doped Graphene material is showing better catalytic activity in minimum time. So, further research has been focused on the catalytic acitivity of rGO-CuO only and it is found that it is efficient in reducing other nitro compounds also such as Picric acid and Nitrobenzene.

Correlation coefficient between plethysmographic variability index and Systolic Pressure Variation as an indicator for fluid responsiveness in hypotensive patients in the ICU/OT.

Background: Prediction of fluid responsiveness in hypotensive patients is a challenge. The correlation between a novel noninvasive dynamic indicator, Pleth Variability Index (PVI ®), and a gold-standard Systolic Pressure Variation (SPV) as a measure of fluid responsiveness was assessed in the Intensive Care Unit (ICU) or Operation Theatre (OT) in a tertiary care hospital.

Methods: A prospective experimental study was conducted over a span of one year on 100 mechanically ventilated patients with hypotension.

Challenges in handling a civilian mass pediatric disaster during flood relief in a partially inundated armed forces medical facility.

Background: Armed forces hospitals are often called upon to provide medical aid to civilians during natural calamities. Though children are often the most vulnerable segment of population in these events, research that addresses their unique needs and the role of armed forces hospitals remains sparse.

Objectives: We examined pediatric morbidity and mortality at a flooded armed forces hospital.

A comparison of the safety and efficacy of minimally invasive surgery versus open surgery in treating cauda equina syndrome: A systematic review and meta-analysis.

Purpose: To compare the safety and efficacy of minimally invasive surgery (MIS) and open surgery (OS) in treating cauda equina syndrome (CES).

Methods: A systematic literature search was conducted, searching relevant databases for studies investigating MIS and/or OS in treating CES. Pooled outcomes and their 95% confidence intervals (CIs) were meta-analyzed via random-effects models.

Mental health hygiene during a health crisis: Exploring factors associated with media-induced secondary trauma in relation to the COVID-19 pandemic.

Aims: Given the risk of developing vicarious trauma through news media has increased during the pandemic, we explored risk factors associated with media induced secondary trauma, and its behavioral and psychological implications.

Methods: An international study ( = 1066), with a diverse sample, was administered in July 2020. We used standardized and validated questionnaires to measure news consumption, media-related trauma, compliance, and paranoia.

3D Porous MoS-Decorated Reduced Graphene Oxide Aerogel as a Heterogeneous Catalyst for Reductive Transformation Reactions.

The MoS-based reduced graphene oxide aerogel (MoS-rGOA)-assisted organic transformation reactions are presented. MoS-rGOA is used as a heterogeneous catalyst for the reduction of benzene derivatives such as benzaldehyde, nitrobenzene, and benzonitrile to benzyl alcohol, aniline, and benzamide and their derivatives, respectively, in green solvents (water/methanol) and green reducing agents (hydrazine hydrate having N and H as byproducts). The mechanistic features of the reduction pathway, substrate scope, and the best suitable conditions by varying the temperature, solvent, reducing agent, catalyst loading, time, etc.

Body appreciation around the world: Measurement invariance of the Body Appreciation Scale-2 (BAS-2) across 65 nations, 40 languages, gender identities, and age.

The Body Appreciation Scale-2 (BAS-2) is a widely used measure of a core facet of the positive body image construct. However, extant research concerning measurement invariance of the BAS-2 across a large number of nations remains limited. Here, we utilised the Body Image in Nature (BINS) dataset - with data collected between 2020 and 2022 - to assess measurement invariance of the BAS-2 across 65 nations, 40 languages, gender identities, and age groups.

Reduced Mortality and Radiation Necrosis After Surgery With Postoperative Stereotactic Radiation in Patients With Multiple Brain Metastases.

Background And Objectives: Although stereotactic radiation has frequently supplanted whole-brain radiation therapy (WBRT) in treating patients with multiple brain metastases, the role of surgery for these patients remains unresolved. No randomized trials have compared surgical resection with postoperative stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT) to SRS/SRT alone. Previous studies addressing surgery for patients with multiple brain metastases are often limited by small sample sizes, a lack of appropriate comparison groups, or a focus on patients treated before recent advances in targeted therapy and immunotherapy.

A genomic score to predict local control among patients with brain metastases managed with radiation.

Background: Clinical predictors of local recurrence following radiation among patients with brain metastases (BrM) provide limited explanatory power. We developed a DNA-based signature of radiotherapeutic efficacy among patients with BrM to better characterize recurrence risk.

Methods: We identified 570 patients with 1487 BrM managed with whole-brain (WBRT) or stereotactic radiation therapy at Brigham and Women's Hospital/Dana-Farber Cancer Institute (2013-2020) for whom next-generation sequencing panel data (OncoPanel) were available.

Minimizing Intracranial Disease Before Stereotactic Radiation in Single or Solitary Brain Metastases.

Background And Objectives: Stereotactic radiotherapy (SRT) in multiple fractions (typically ≤5) can effectively treat a wide range of brain metastases, including those less suitable for single-fraction stereotactic radiosurgery (SRS). Prior prospective studies on surgical resection with stereotactic radiation have focused exclusively on SRS, and retrospective studies have shown equivocal results regarding whether surgery is associated with improved outcomes compared with SRT alone. We compared resection with postoperative cavity SRT or SRS to SRT alone in patients with 1 brain metastasis, while including patients receiving SRS alone as an additional reference group.

Without Spouse: Phenomenology of Widowhood among Hindu Young Widows.

When a woman is widowed, it is a traumatic moment in her life. The pain would aggravate a widowed woman whose husband died at a younger age. This paper attempts to depict the lived experience of widowhood from the perspective of young Hindu widows by using a descriptive phenomenological approach guided by Husserlian philosophy.

Just wrong? Or just WEIRD? Investigating the prevalence of moral dumbfounding in non-Western samples.

Moral dumbfounding occurs when people maintain a moral judgment even though they cannot provide a reason for this judgment. Dumbfounded responding may include admitting to not having reasons, or the use of unsupported declarations ("It's just wrong") as justification for a judgment. Published evidence for dumbfounding has drawn exclusively on samples of WEIRD backgrounds (Western, educated, industrialized, rich, and democratic), and it remains unclear to what extent the phenomenon is generalizable to other populations.

Laser Interstitial Thermal Therapy for the Treatment of Primary and Metastatic Brain Tumors: A Systematic Review and Meta-Analysis.

Background: Laser interstitial thermal therapy (LITT) is a minimally invasive treatment option for intracranial tumors that are challenging to treat via traditional methods; however, its safety and efficacy are not yet well validated in the literature. The objectives of the study were to assess the available evidence of the indications and adverse events (AEs) of LITT and 1-year progression-free survival and 1-year overall survival in the treatment of primary and secondary brain tumors.

Methods: A comprehensive literature search was conducted through the databases PubMed, Embase, and the Cochrane Library until October 2021.

Incidence proportion and prognosis of leptomeningeal disease among patients with breast vs. non-breast primaries.

Background: Leptomeningeal disease (LMD) is a relatively uncommon manifestation of advanced cancer. Patients with LMD carry a poor prognosis and often decline rapidly, complicating inclusion in clinical trials. Identification of LMD subsets of greater incidence and more favorable prognosis might facilitate dedicated clinical trials in the future.

Recent Trends in Photocatalytic Enantioselective Reactions.

Enantioselective synthesis through photocatalysis is one of the highly preferred approaches towards preparation of optically active compounds. This review elaborates and critically analyzes the different strategies of photocatalytic enantioselective reactions through H-bonding, transition metal catalysis, phase-transfer catalysis (PTC), chiral Lewis acid catalysis, N-heterocyclic carbene catalysis, and amine catalysis, and also explores ion pairs. In addition, it explains the different catalysis modes with multifunctional approaches for enantioselective photocatalytic reactions.

Multinational evaluation of the measurement invariance of the Level of Personality Functioning Scale-brief form 2.0: Comparison of student and community samples across seven countries.

The Level of Personality Functioning Scale (LPFS) was introduced as a dimensional rating of impairments in self- and interpersonal functioning, and the LPFS-Brief Form (LPFS-BF) was the first published corresponding self-report. The updated LPFS-BF 2.0 has been translated into several languages and international research supports many of the instrument's psychometric properties; however, its measurement invariance has only been evaluated across a few countries.