Future Directions in Understanding Acute and Chronic Effects of Mental Fatigue in Sports: A Commentary on Bridging Laboratory Findings and Real-World Applications.

Background: Mental fatigue (MF) is a psychobiological state that could negatively impact physical and cognitive performance, although the extent of this impact remains controversial. While laboratory studies have provided valuable insights into the acute effects of MF, their ecological validity in real-world sport settings remains limited. Recent research indicates that MF can naturally arise during sport activities, leading to chronic effects on endurance and perceptual-cognitive skills.

The impact of sprint, middle-distance, and long-distance orienteering races on perceived mental fatigue in national level orienteers.

Experiencing mental fatigue (MF) before an orienteering race can lead to a slower completion time. This study aimed to explore the changes in perceived MF, mood and other psychological responses during an orienteering competition. Sixteen national level orienteering athletes (20.

Nonlinearities in Black Hole Ringdowns.

The gravitational wave strain emitted by a perturbed black hole (BH) ringing down is typically modeled analytically using first-order BH perturbation theory. In this Letter, we show that second-order effects are necessary for modeling ringdowns from BH merger simulations. Focusing on the strain's (ℓ,m)=(4,4) angular harmonic, we show the presence of a quadratic effect across a range of binary BH mass ratios that agrees with theoretical expectations.

International orienteering experts' consensus on the definition, development, cause, impact and methods to reduce mental fatigue in orienteering: A Delphi study.

Orienteering is an outdoor activity wherein participants use a map and compass to locate control points and choose the quickest path to the next control point in a natural environment. Attentional focus, rapid decision-making, and high aerobic fitness may influence orienteering performance. Therefore, this research aimed to seek international orienteering expert consensus regarding the definition, development, causes, influences and methods to reduce mental fatigue (MF) in orienteering based on practical experience.

A Case Series of Plexiform Neurofibroma: The Unusual Presentations and Surgical Challenges.

Neurofibromatosis type one (NF-1) is an autosomal dominant neurocutaneous disorder also known as Von Recklinghausen disease. Plexiform neurofibroma is a rare kind of NF-1 where the neurofibroma originates from nerve sheath cells or subcutaneous peripheral nerves. It is pathognomonic of NF-1, and isolated occurrence is relatively rare.

MicroRNAs regulate the sesquiterpenoid hormonal pathway in and other arthropods.

Arthropods comprise the majority of all described animal species, and understanding their evolution is a central question in biology. Their developmental processes are under the precise control of distinct hormonal regulators, including the sesquiterpenoids juvenile hormone (JH) and methyl farnesoate. The control of the synthesis and mode of action of these hormones played important roles in the evolution of arthropods and their adaptation to diverse habitats.

Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites.

Dronedarone, a multiple ion channel blocker is prescribed for the treatment of paroxysmal and persistent atrial fibrillation. While dronedarone does not precipitate toxicities like its predecessor amiodarone, its clinical use has been associated with idiosyncratic hepatic and cardiac adverse effects and drug-drug interactions (DDIs). As dronedarone is a potent mechanism-based inactivator of CYP3A4 and CYP3A5, a question arose if it exerts a similar inhibitory effect on CYP2J2, a prominent cardiac CYP450 enzyme.

Adhesion-dependent modulation of actin dynamics in Jurkat T cells.

Contact formation of T cells with antigen presenting cells results in the engagement of T cell receptors (TCRs), recruitment and aggregation of signaling proteins into microclusters and ultimately, T cell activation. During this process, T cells undergo dramatic changes in cell shape and reorganization of the cytoskeleton. While the importance of the cytoskeleton in T cell activation is well known, the dynamics of the actin cytoskeleton and how it correlates with signaling clusters during the early stages of spreading is not well understood.

No-hair theorem for the Galileon.

We consider a Galileon field coupled to gravity. The standard no-hair theorems do not apply because of the Galileon's peculiar derivative interactions. We prove that, nonetheless, static spherically symmetric black holes cannot sustain nontrivial Galileon profiles.

Progressive hair straightening using an automated flat iron: function of silicones.

An automated hair iron was built with which the hair temperature, contact force of the iron against the hair tress, and gliding speed were controlled. The changes in keratin were characterized by several techniques including differential scanning calorimetry, birefringence measurements, and wet tensile tests. Undamaged curly hair was ironed for several iron cycles at temperatures ranging from 120°C to 175°C and washed between each iron cycle.

Cosmic microwave background power asymmetry from non-Gaussian modulation.

Non-Gaussianity in the inflationary perturbations can couple observable scales to modes of much longer wavelength (even superhorizon), leaving as a signature a large-angle modulation of the observed cosmic microwave background power spectrum. This provides an alternative origin for a power asymmetry that is otherwise often ascribed to a breaking of statistical isotropy. The non-Gaussian modulation effect can be significant even for typical ~10(-5) perturbations while respecting current constraints on non-Gaussianity if the squeezed limit of the bispectrum is sufficiently infrared divergent.

No-go theorems for generalized chameleon field theories.

The chameleon, or generalizations thereof, is a light scalar that couples to matter with gravitational strength, but whose manifestation depends on the ambient matter density. A key feature is that the screening mechanism suppressing its effects in high-density environments is determined by the local scalar field value. Under very general conditions, we prove two theorems limiting its cosmological impact: (i) the Compton wavelength of such a scalar can be at most ~/= 1 MPc at the present cosmic density, which restricts its impact to nonlinear scales; and (ii) the conformal factor relating Einstein- and Jordan-frame scale factors is essentially constant over the last Hubble time, which precludes the possibility of self-acceleration.

Proposal for an observational test of the Vainshtein mechanism.

Modified gravity theories capable of genuine self-acceleration typically invoke a Galileon scalar which mediates a long-range force but is screened by the Vainshtein mechanism on small scales. In such theories, nonrelativistic stars carry the full scalar charge (proportional to their mass), while black holes carry none. Thus, for a galaxy free falling in some external gravitational field, its central massive black hole is expected to lag behind the stars.

Membrane dynamics correlate with formation of signaling clusters during cell spreading.

The morphology and duration of contacts between cells and adhesive surfaces play a key role in several biological processes, such as cell migration, cell differentiation, and the immune response. The interaction of receptors on the cell membrane with ligands on the adhesive surface leads to triggering of signaling pathways, which allow cytoskeletal rearrangement, and large-scale deformation of the cell membrane, which allows the cell to spread over the substrate. Despite numerous studies of cell spreading, the nanometer-scale dynamics of the membrane during formation of contacts, spreading, and initiation of signaling are not well understood.

Equivalence principle for scalar forces.

The equivalence of inertial and gravitational masses is a defining feature of general relativity. Here, we clarify the status of the equivalence principle for interactions mediated by a universally coupled scalar, motivated partly by recent attempts to modify gravity at cosmological distances. Although a universal scalar-matter coupling is not mandatory, once postulated, it is stable against classical and quantum renormalizations in the matter sector.

Size bias in galaxy surveys.

Only certain galaxies are included in surveys: those bright and large enough to be detectable as extended sources. Because gravitational lensing can make galaxies appear both brighter and larger, the presence of foreground inhomogeneities can scatter galaxies across not only magnitude cuts but also size cuts, changing the statistical properties of the resulting catalog. Here we explore this size bias and how it combines with magnification bias to affect galaxy statistics.

Horizon ratio bound for inflationary fluctuations.

We demonstrate that the gravity wave background amplitude implies a robust upper bound on the wavelength-to-horizon ratio at the end of inflation: lambda/H(-1) less than or approximately equal e(60), as long as the cosmic energy density does not drop faster than radiation subsequent to inflation. This limit implies that N, the number of e-folds between horizon exit and the end of inflation for wave modes of interest, is less, similar 60 plus a model-dependent factor-for vast classes of slow-roll models, N less than or approximately equal 67. As an example, this bound solidifies the tension between observations of the cosmic microwave background anisotropies and chaotic inflation with a phi(4) potential by closing the escape hatch of large N (<62).