Tissue Engineering Scaffold Material with Enhanced Cell Adhesion and Angiogenesis from Soy Protein Isolate Loaded with Bio Modulated Micro-TiO Prepared via Prolonged Sonication for Wound Healing Applications.

Tissue engineering is a technique that promotes healing by creating an ideal environment for endogenous cells to migrate and grow into the site of injury via a scaffold, improving regeneration and reducing the time required for in vitro cell culture. In this work, the effect of the addition of sonicated TiO in the soy protein isolate (SPI) matrix for tissue engineering applications was studied. In comparison to adding expensive nano TiO, this method of incorporating sonicated TiO into the SPI matrix will aid in achieving improved properties at a lower cost.

pH indicator films fabricated from soy protein isolate modified with chitin nanowhisker and flower extract.

Sensor films are finding wide range of applications. Different type of sensing films is fabricated for the identification of chemicals, ions, heavy metals, changes in the pH, etc. The present report is on the fabrication of pH sensitive films from completely natural sources-soy protein isolate, chitin nano whiskers and flower extract.

Development of starch based intelligent films by incorporating anthocyanins of butterfly pea flower and TiO and their applicability as freshness sensors for prawns during storage.

Intelligent pH sensitive starch films were developed by incorporation of anthocyanin pigment extracted from butterfly pea flower (BPE) and nanosized TiO using the method of solution casting. This research work evaluated the influence of BPE and TiO on the physical and structural properties of starch films. The physical properties of the starch films could be significantly altered by the addition of BPE and or TiO.

Novel core-shell dextran hybrid nanosystem for anti-viral drug delivery.

Zidovudine (AZT) is an antiviral drug extensively used for combating the global pandemic- HIV/AIDS. However, its uses are overshadowed by its short half -life, poor aqueous solubility and inability to cross physiological barriers. This study highlights a nanosystem consisting of dextran and stearic acid for AZT delivery.

Electrospun polylactic acid-chitosan composite: a bio-based alternative for inorganic composites for advanced application.

Fabricating novel materials for biomedical applications mostly require the use of biodegradable materials. In this work biodegradable materials like polylactic acid (PLA) and chitosan (CHS) were used for designing electrospun mats. This work reports the physical and chemical characterization of the PLA-CHS composite, prepared by the electrospinning technique using a mixed solvent system.

Poly (vinyl pyrrolidone)-lipid based hybrid nanoparticles for anti viral drug delivery.

Zidovudine (AZT) is an antiviral drug with moderate solubility in water. It has limited application due to its short half life in vivo and consequent requirement for frequent administrations. To solve this problem, zidovudine loaded polyvinylpyrrolidone (PVP)/stearic acid (SA)-polyethylene glycol (PEG) nanoparticles (PSNPs) were developed.

Encapsulation of zidovudine in PF-68 coated alginate conjugate nanoparticles for anti-HIV drug delivery.

Retroviral drug delivery faces many challenges due to its low bioavailability, short half life and hydrophobicity. In this study, the anti viral drug zidovudine (AZT) was encapsulated inside the amide functionalised alginate nanoparticles (AZT-GAAD NPs) using emulsion solvent evaporation method. The amide derivative of alginate was prepared by coupling reaction with d,l glutamic acid using carbodiimide activation chemistry.

Gelatin modified lipid nanoparticles for anti- viral drug delivery.

The major challenges to clinical application of zidovudine are its moderate aqueous solubility and relative short half-life and serious side effects due to frequent administrations. We investigated the preparation of zidovudine-loaded nanoparticles based on lipids which were further modified with the polymer gelatin. Formulation and stability of the modified nanoparticles were analysed from the physico-chemical characterizations.

Novel dendritic structure of alginate hybrid nanoparticles for effective anti-viral drug delivery.

Lipid-polymer hybrid nanoparticles have recently gathered much attention as nanoplatforms for drug delivery applications due to their unique structural properties. In this study zidovudine (AZT) loaded hybrid nanoparticles of alginate (ALG) and stearic acid- poly ethylene glycol (SA-PEG) were synthesized. The structural characterization of drug loaded hybrid nanoparticles were studied using FT-IR spectroscopy, DLS and TEM analysis.

Evaluation of in-vitro cytotoxicity and cellular uptake efficiency of zidovudine-loaded solid lipid nanoparticles modified with Aloe Vera in glioma cells.

Zidovudine loaded solid lipid nanoparticles of stearic acid modified with Aloe Vera (AV) have been prepared via simple emulsion solvent evaporation method which showed excellent stability at room temperature and refrigerated condition. The nanoparticles were examined by Fourier transform infrared spectroscopy (FT-IR), which revealed the overlap of the AV absorption peak with the absorption peak of modified stearic acid nanoparticles. The inclusion of AV to stearic acid decreased the crystallinity and improved the hydrophilicity of lipid nanoparticles and thereby improved the drug loading efficacy of lipid nanoparticles.

Nanocelluloses from jute fibers and their nanocomposites with natural rubber: Preparation and characterization.

Nanocellulose fibers having an average diameter of 50nm were isolated from raw jute fibers by steam explosion process. The isolation of nanocellulose from jute fibers by this extraction process is proved by SEM, XRD, FTIR, birefringence and TEM characterizations. This nanocellulose was used as the reinforcing agent in natural rubber (NR) latex along with crosslinking agents to prepare crosslinked nanocomposite films.