Modulation of the Th1/Th2 bias by an immunoglobulin histamine complex in the ovalbumin allergy mouse model.

Vaccination with the antiallergic drug Histaglobin is used to treat a broad range of human allergic diseases including bronchial asthma, allergic rhinitis, and atopic dermatitis. In order to further elucidate its functional activity, Histaglobin was investigated in an in vivo mouse allergy model. Mice were sensitized with ovalbumin either prior to or after Histaglobin treatment, and its antiallergic potential was evaluated.

[Pharmacokinetic study of a new benzyl-1 isoquinoline derivative (458 L) after oral administration in men].

Pharmacokinetic study of 458 L. via oral route, was performed in twelve normal volunteers, in a randomized crossover design of three galenic forms. Plasma concentrations were determined, after extraction, by HPLC, with spectrofluorimetric detection.

Studies on the immunostimulating and anti-tumour activity of a fraction isolated from Corynebacterium granulosum.

The immunostimulating activity of the anaerobic corynebacteriae is well documented. Fractions isolated from while cells have not been much investigated. We have reported that the immunostimulating activity is present in fractions isolated from Corynebacterium granulosum.

[Antagonistic effect of a fraction isolated from Corynebacterium granulosum toward cyclophosphamide immunosuppression in mice].

A fraction isolated from Corynebacterium granulosum was shown to be capable of increasing significantly the antibody level in response to immunization of the Mouse with sheep red blood cells. The animals stimulated with this fraction become very resistant to the effect of cyclophosphamide. In contrast, the action of the fraction in previously immuno-suppressed animals is nil or very low.

[The effect of somatic antigen from Bacillus subtilis on migration of mouse macrophages].

The migration of mice peritoneal macrophages has been studied on agar plates. The migration of the macrophages from mice treated by the intra peritoneal route by a somatic antigen of Bacillus subtilis, was 37% less than the migration of the macrophage from control mice. The presence of the antigen in the gel did not modify the migration of macrophages in either treated or control mice.

[Reversal of the depressive power of cyclophosphamide on the anti-infectious defense of the mouse by means of a somatic antigen from Bacillus subtilis].

In the experimental conditions reported the cyclophosphamide increases the pathogenic effect of Escherichia coli in mice. Treating the animals with a somatic antigen of Bacillus subtilis, reverses the aggravating effect of cyclophosphamide on the experimental infection. Similar results are obtained through the parenteral and the rectal routes.