Role of mast cells in the pathogenesis of oral submucous fibrosis: a systematic review and meta-analysis.

Background: Oral Submucous Fibrosis (OSMF) is an oral potentially malignant disorder (OPMD) that commonly occurs in the South Asian population as there is high usage of areca nut. There has been extensive research on the pathogenesis and treatment of this condition. It is well-established in the scientific literature that mast cells (MC) have a definitive role in several inflammatory disorders.

Unveiling the Impact of Electronic Cigarettes (EC) on Health: An Evidence-Based Review of EC as an Alternative to Combustible Cigarettes.

Cigarette smoking has been considered a major public health concern due to its serious impact on health. However, smokers intending to quit may find long-term abstinence challenging. When smoking an electronic cigarette (EC), users can experience a sensation and taste similar to that of smoking a combustible cigarette.

Clinical and histopathological correlation of oral malignancy and potentially malignant disorders based on a screening program at high-risk population in Tamil Nadu, India.

Background: There is a high incidence of oral cancer and oral potential malignant disorder observed in southeast Asian countries such as India. Our study aimed to assess the correlation between screening and histopathological diagnosis and to predict the specificity and sensitivity of chair-side/field-based assessment of the oral lesion.

Materials And Methods: A total of 40,852 subjects aged between 20 and 60 years were screened in the 1st phase of the study, suspected lesions were stained with toluidine blue (Manufactured by Otto Chemicals private limited, India) at two time points, those who stained positively during the two points were taken up for biopsy.

Potential role of fibroblast senescence in malignant transformation of oral submucous fibrosis.

Oral Submucous Fibrosis (OSMF) is a disorder that occurs primarily due to the usage of betel nut and paan masala. The rate of malignant transformation from OSMF is 26 %. There are several markers to predict this malignant transformation such as inflammatory mediators, hypoxia, Cell cycle alteration, alteration in oncosuppressor genes, angiogenesis-related molecules, genetic susceptibility, and senescence.