Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes.

Background: Aberrant deoxyribonucleic acid (DNA) contributes to inflammasome orchestrated progression of chronic inflammatory diseases like diabetes and periodontitis. The purpose of the present study was to estimate salivary levels of DNA sensing inflammasomes, absent in melanoma 2 (AIM2), interferon γ inducible protein (IFI16), and cytokine interleukin 18 (IL18) in individuals with periodontitis, diabetes, and healthy controls and interpret its association with periodontal and diabetic parameters.

Methods: Salivary levels of AIM2, IFI16, and IL18 were estimated by enzyme linked immunosorbent assay (ELISA) in a total of 120 individuals (n = 30 in each group), namely, healthy (Group 1), periodontitis (Group 2), diabetes (Group 3), and diabetes with periodontitis (Group 4).

Comparison of anti-plaque and anti-gingivitis effect of curcumin and chlorhexidine mouth rinse in the treatment of gingivitis: A clinical and biochemical study.

Background: To evaluate and compare the effect of curcumin (CMN) mouth rinse with chlorhexidine (CHX) mouth rinse on clinical parameters and reactive oxygen metabolites (ROM) levels in participants with chronic gingivitis.

Materials And Methods: Thirty plaque-induced generalized chronic gingivitis participants were randomly assigned to three groups - Group I (control/saline), Group II (CHX), and Group III (CMN), respectively. Baseline plaque index (PI), gingival index (GI), and salivary ROM were estimated, and oral prophylaxis was done.

Dental implants in bilateral bifid canal and compromised interocclusal space using cone beam computerized tomography.

Knowledge of various anatomic landmarks is pivotal for important success. Bifid canals pose a challenge and can lead to difficulties while performing implant surgery in the mandible. Bifid canals can be diagnosed with panoramic radiography and more accurately with cone beam computerized tomography (CBCT).

Autoimmune correlation of rheumatoid arthritis and periodontitis.

Rheumatoid arthritis and periodontitis, both, chronic inflammatory diseases share certain common diagnostic, pathological, immunogenetic and therapeutic features. A recently discovered enzymatic mimicry between human and bacterial species is novel and it opens up a new terrain for therapeutic blockade in the management of rheumatoid arthritis.

Immunolocalization of Bcl-2 oncoprotein in amlodipine-induced gingival overgrowth.

Background: Drug-induced gingival overgrowth (DIGO) is one of the unwanted side effects of amlodipine therapy, but the pathogenesis still remains unclear. Apoptosis, which plays a ubiquitous role in tissue homeostasis, including gingiva, may be involved in the development of gingival enlargement.

Aims And Objectives: (i) To study the distribution of Bcl-2 in healthy and overgrown gingival tissues.

A novel surgical procedure for papilla reconstruction using platelet rich fibrin.

Loss of interdental papilla predisposes to phonetic, functional, and esthetic problem. Surgical techniques are manifold, but are challenging and very unpredictable. The purpose of this case report is to present the use of platelet rich fibrin (PRF) in the reconstruction of papilla in the maxiallry anterior region of a forty year old woman who presented with loss of interdental papillae in 11, 12 and 11, 21 region.