The Reality of Evaluating Urine Spot Sodium and Urine Spot Sodium Creatinine Ratio in Furosemide Stress Test as a New Biomarker in Diagnosing Progressive AKI in Critically Ill.

Chatterjee R, Gupta L. The Reality of Evaluating Urine Spot Sodium and Urine Spot Sodium Creatinine Ratio in Furosemide Stress Test as a New Biomarker in Diagnosing Progressive AKI in Critically Ill. Indian J Crit Care Med 2024;28(12):1089-1090.

Pilot Randomized Clinical Trial of a Passive Non-invasive Positive End-Expiratory Pressure (PEEP) Device for Delivering Positive Pressure Therapy Compared to Standard Care in Non-critically Ill Patients With COVID-19.

Background: During the COVID-19 pandemic, there were reports of a shortage of ventilators and oxygen supply, particularly in resource-limited settings. We report the preliminary evaluation of a non-invasive positive end-expiratory pressure (PEEP) mask in hospitalized non-critically ill patients with COVID-19.

Methods: We randomly assigned hospitalized adult patients with confirmed COVID-19 infection and requiring greater than 40% supplemental oxygen to either standard care oxygen delivery (control) or via Materialise passive non-invasive PEEP device mask (intervention; Belgium).

Linking Generalized Ligamentous Laxity to Musculoskeletal Injury: A Study in the Indian Population.

Introduction Generalized ligamentous laxity (GLL) is defined as an increased range of motion across multiple joints in an individual beyond the mean range of motion in the general population, with a reported prevalence between 5% and 15%. It becomes less common with age and is more common in females and in the lower limbs. Musculoskeletal injury (MSI) is damage to musculoskeletal systems, usually due to strenuous activity.

Comparison of gum elastic bougie-guided insertion of LMA Protector versus the conventional method in achieving oesophagal patency - A randomised comparative study.

Background And Aims: The passage of a Ryle's tube through the drain port on the laryngeal mask airway (LMA) Protector has been reported to be arduous despite the larger gastric channel. There are no studies on the evaluation of the guided insertion of LMA Protector to achieve adequate gastrointestinal drainage function.

Methods: This randomised study included 132 patients who underwent surgery under general anaesthesia.

Comparative study of functional outcomes of arthroscopic anterior cruciate ligament reconstruction using anteromedial portal and translateral all-inside technique.

Background: Anterior Cruciate Ligament (ACL) injuries are common in the active population of the Armed Forces. Symptomatic instability prompts individuals to seek a cure or a sheltered appointment. Despite the increasing numbers of ACL reconstructions performed, the outcomes have not been so spectacular with only a meager percentage of our patients returning to preinjury levels of activity.

A Comprehensive Analysis and Review of Artificial Intelligence in Anaesthesia.

In the field of anaesthesia, artificial intelligence (AI) has become a game-changing technology. Applications of AI include keeping records, monitoring patients, calculating and administering drugs, and carrying out mechanical procedures. This article explores the current uses, challenges, and prospective applications of AI in anaesthesia practices.

Benzodiazepines Reduce Blood Pressure in Short Term: A Systematic Review and Meta-analysis.

Purpose Of Review: Benzodiazepines, due to their anxiolytic properties, are prescribed to reduce anxiety and insomnia. They might have hypotensive effect via potentiation of the inhibitory effect of gamma-amino butyric acid (GABA) in the central nervous system and vasodilatory properties. However, studies comparing the effect of benzodiazepines in lowering blood pressure (BP) are equivocal.

Multidomain Convolution Neural Network Models for Improved Event-Related Potential Classification.

Two convolution neural network (CNN) models are introduced to accurately classify event-related potentials (ERPs) by fusing frequency, time, and spatial domain information acquired from the continuous wavelet transform (CWT) of the ERPs recorded from multiple spatially distributed channels. The multidomain models fuse the multichannel Z-scalograms and the V-scalograms, which are generated from the standard CWT scalogram by zeroing-out and by discarding the inaccurate artifact coefficients that are outside the cone of influence (COI), respectively. In the first multidomain model, the input to the CNN is generated by fusing the Z-scalograms of the multichannel ERPs into a frequency-time-spatial cuboid.

Management of hereditary angioedema in resource-constrained settings: A consensus statement from Indian subcontinent.

Hereditary angioedema (HAE) is an uncommon disorder characterized clinically by recurrent episodes of nonitchy subcutaneous and/or submucosal swellings. The estimated prevalence of HAE is ~ 1: 10,000 to 1: 50,000. There are no prevalence data from India, however, estimates suggest that there are 27,000 to 135,000 patients with HAE in India at present.

Effect of milnacipran on brain‑derived neurotrophic factor and oxidative stress biomarkers in patients of major depressive disorder.

Emerging hypotheses in the pathophysiology of major depressive disorder (MDD) suggest important role of neurotrophic factors and oxidative stress. This study assessed the effect of milnacipran (a dual serotonin‑noradrenaline reuptake inhibitor) on brain‑derived neurotrophic factor (BDNF) and oxidative stress biomarkers i.e.

Sugammadex Neostigmine for Reversal of Neuromuscular Blockade in Adults and Children: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Background: Cholinesterase inhibitors, such as neostigmine and edrophonium, commonly used to reverse the residual effects of nondepolarizing neuromuscular blocking drugs at the end of surgery are associated with a high rate of residual neuromuscular blockade (NMB). Due to its direct mechanism of action, sugammadex is associated with rapid and predictable reversal of deep NMB. The current analysis compares the clinical efficacy and risk of postoperative nausea and vomiting (PONV) on using sugammadex or neostigmine for routine NMB reversal in adult and pediatric populations.

Exploiting the Cone of Influence for Improving the Performance of Wavelet Transform-Based Models for ERP/EEG Classification.

Features extracted from the wavelet transform coefficient matrix are widely used in the design of machine learning models to classify event-related potential (ERP) and electroencephalography (EEG) signals in a wide range of brain activity research and clinical studies. This novel study is aimed at dramatically improving the performance of such wavelet-based classifiers by exploiting information offered by the cone of influence (COI) of the continuous wavelet transform (CWT). The COI is a boundary that is superimposed on the wavelet scalogram to delineate the coefficients that are accurate from those that are inaccurate due to edge effects.

Angiotensin receptor blockers for the treatment of covid-19: pragmatic, adaptive, multicentre, phase 3, randomised controlled trial.

Objective: To determine whether disrupting the renin angiotensin system with angiotensin receptor blockers will improve clinical outcomes in people with covid-19.

Design: CLARITY was a pragmatic, adaptive, multicentre, phase 3, randomised controlled trial.

Setting: 17 hospital sites in India and Australia.

IADVL Academy Position Statement on Emerging Dermatoses in India: Monkeypox.

As we were on the road to recovery from the coronavirus disease-19 (COVID-19) pandemic, the world is waking up to yet another potential adversary. Monkeypox (or human monkeypox) caused by monkeypox virus (an orthopox virus) is fast emerging in more than 80 countries worldwide, where it has never been historically reported. We in India, have already seen the advent of this outbreak since July 2022, with a progressive rise in number of cases being seen.