NEW ASPECTS OF THE INTERACTION OF COPPER (II) WITH SERUM ALBUMIN: VOLTAMMETRIC AND MICROCALORIMETRIC STUDIES.

Structural organization of serum albumins - the most abundant globular proteins in serum plasma - gives rise to their extraordinary binding and functional capacity. Various classes of ligands, including the metal ions can be captured and transported by albumins. Metal binding to human serum albumin, HSA, that is an essential multipurpose target for the modern biomedicine, to its bovine equivalent, BSA, and other mammalian analogs have been extensively explored in the context of metabolism of essential metal ions, like Cu2+.