Diagnostic Performance of a Deep Learning-Powered Application for Aortic Dissection Triage Prioritization and Classification.

This multicenter retrospective study evaluated the diagnostic performance of a deep learning (DL)-based application for detecting, classifying, and highlighting suspected aortic dissections (ADs) on chest and thoraco-abdominal CT angiography (CTA) scans. CTA scans from over 200 U.S.

DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing.

Targeting intracellular inhibiting proteins has been revealed to be a promising strategy to improve CD8 T cell anti-tumor efficacy. Here, we are focusing on intracellular inhibiting proteins specific to TCR signaling: DOK1 and DOK2 expressed in T cells. We hypothesized that depletion of intracellular inhibition checkpoint DOK1 and DOK2 could improve CD8 T-cell based cancer therapies.

Innovative Design of BNKT-SLZT Ceramics: Maximizing the Polarization Difference for Enhanced Energy Storage.

Lead-free relaxor ferroelectric ceramics with outstanding energy-storage (ES) density () and high ES efficiency () are crucial for advanced pulse-power capacitors. This study introduces a strategic approach to maximizing the polarization difference (Δ) by inducing a transition from the ferroelectric phase to the ergodic relaxor (ER) phase. By employing this strategy, a series of ceramics, (1 - )(BiNaK)TiO-(SrLa)(ZrTi)O (BNKT-SLZT), with varying SLZT content ( = 0.

Negative intracellular regulators of T-cell receptor (TCR) signaling as potential antitumor immunotherapy targets.

Immunotherapy strategies aim to mobilize immune defenses against tumor cells by targeting mainly T cells. Co-inhibitory receptors or immune checkpoints (ICPs) (such as PD-1 and CTLA4) can limit T cell receptor (TCR) signal propagation in T cells. Antibody-based blocking of immune checkpoints (immune checkpoint inhibitors, ICIs) enable escape from ICP inhibition of TCR signaling.

CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation.

Immunotherapies targeting the "don't eat me" myeloid checkpoint constituted by CD47 SIRPα interaction have promising clinical potential but are limited by toxicities associated with the destruction of non-tumor cells. These dose-limiting toxicities demonstrate the need to highlight the mechanisms of anti-CD47-SIRPα therapy effects on non-tumor CD47-bearing cells. Given the increased incidence of lymphopenia in patients receiving anti-CD47 antibodies and the strong ADCC (antibody-dependent cellular cytotoxicity) effector function of polymorphonuclear cells (), we investigated the behavior of primary PMNs cocultured with primary T cells in the presence of anti-CD47 mAbs.

Chronic IL-15 Stimulation and Impaired mTOR Signaling and Metabolism in Natural Killer Cells During Acute Myeloid Leukemia.

Natural Killer (NK) cells are potent anti-leukemic immune effectors. However, they display multiple defects in acute myeloid leukemia (AML) patients leading to reduced anti-tumor potential. Our limited understanding of the mechanisms underlying these defects hampers the development of strategies to restore NK cell potential.

[General anesthetics as a factor of effective neuroprotection in ischemic stroke models].

Stroke is the second leading cause of death in the world. Unfortunately, only a few drugs have been proved in clinical trials. Drug development of the last decade has been focused substantially on a promising and heterogeneous group of neuroprotective drugs.

[Influence of alpha-lipoic acid on liver glutathione system of healthy and Ehrlich ascites carcinoma transplanted mice].

Influence of alpha-lipoic acid (LA) on liver glutathione system of Ehrlich ascites carcinoma (EAC) transplanted mice was studied. LA causes multidirectional influence on glutathione system of healthy mice. EAC transforms LA influence, strengthening prooxidative effects more expressed at introduction in early terms after inoculation of the tumor.

[Extended lymphadenectomy in surgery of extensive stomach cancer].

The results of 226 extended surgeries for extensive cancer of the stomach, including 157 gastrectomies, 53 subtotal resections and 16 proximal resections, have been studied. Metastatic spreading into the lymph nodes along the left-side gastric artery was observed in 56.6%, in the hepatoduodenal ligament--25.

[Topographic-anatomical aspects of extensive lymphadenectomy in gastric cancer].

Data on 160 extensive surgical procedures for gastric cancer were analysed. Gastrectomy was performed in 109 cases of whom 12 (11%) died; subtotal resection--in 42 with 2 (4.8%) postoperative deaths whereas proximal resection--in 9 patients (no fatalities).

[Results of combined treatment of cancer of the gastric antrum and gastric body].

The paper discusses the results of a cooperative study concerned with the immediate and end results of treatment of stage III cancer of the antral part and body of the stomach in patients randomly assigned to receive surgery either alone (142 cases) or in combination with preoperative Co 60 gamma teletherapy (139). Preoperative radiotherapy was not followed by increase in postoperative complication rate as compared to surgery alone. Combined treatment appeared to assure higher three- and five-year survival.

[Surgical treatment of cancer of the proximal section of the stomach].

The report deals with an evaluation of the results of 430 radical operations for cancer of the proximal part of the stomach. The lethality rates following proximal resection were 16.8% and 13.