Is Statin Use Associated With Risk of Thyroid Diseases? Results of a Retrospective Cohort Study.

Background: Given the ubiquity of statin use and prevalence of thyroid diseases, such as thyroid cancer, hyperthyroidism, and thyroiditis, understanding their association deserves further attention.

Objective: To examine the association between statin use and thyroid cancer, thyrotoxicosis, goiter, and thyroiditis.

Methods: Using Tricare data, 2 propensity score (PS)-matched cohorts of statin users and nonusers were formed: (1) a PS-matched general cohort (all patients aged 30-85 years) and (2) a PS-matched healthy cohort (excluded patients with cardiovascular diseases or severe comorbidities).

Association of Statin Therapy With Risk of Epilepsy in 2 Propensity Score-Matched Cohorts.

Background: Studies have suggested that statins may have a neuroprotective effect against epilepsy. However, evidence from rat models and case reports have suggested an opposite effect. Overall data are limited.