A Retrospective Study on the Expression of E-Cadherin in Endometrial Carcinoma.

E-cadherin is a cell adhesion molecule crucial for maintaining cellular integrity and survival. E-cadherin is the focus of this study, which aims to evaluate its immunohistochemical staining patterns in endometrial carcinoma (EC). Material and methods In this retrospective study, 25 formalin-fixed, paraffin-embedded tissue blocks of EC were retrieved from the Department of Pathology at Saveetha Medical College.

The Heinous Hobnail: A Case Report of the Rare Hobnail Variant of Papillary Thyroid Carcinoma.

The hobnail variant of papillary thyroid carcinoma (HVPTC) represents a distinctive and relatively rare histological subtype of thyroid malignancies. This variant is characterized by its unique cellular morphology with a hobnail appearance, that is, cells with apically positioned nuclei. There are other characteristics like micropapillary pattern and loss of cohesiveness of cells, which are indicative of HVPTC.

A Case of Leukemic Pleural Infiltration in the Blast Crisis Phase of Chronic Myeloid Leukemia: An Unusual Extramedullary Involvement.

The development of pleural effusion in chronic myeloid leukemia (CML) is not well-understood and rarely documented in literature. Extramedullary involvement (EMI), which occurs in about 10% of CML cases, typically affects lymph nodes and the spleen. Instances of extensive infiltration of leukemic cells into the pleura are infrequently reported in CML.

An Unusual Case of Hepatocellular Carcinoma in a Healthy Adolescent Male.

Hepatocellular carcinoma (HCC) is a rare occurrence in adolescents, especially in those without underlying liver diseases. We present the case of a 16-year-old male, having no significant relevant previous medical history, who presented with signs and symptoms of an abdominal mass and hepatic dysfunction. Diagnostic investigations unveiled a startling finding of HCC, challenging the conventional understanding of this malignancy's epidemiology and etiology in young individuals.

Synchronous Gastric and Colonic Adenocarcinoma: A Case Report With its Molecular Implications.

Multiple primary tumors are rare but their incidence is increasing nowadays with advancements in diagnostic methods and the extended survival of individuals previously treated for malignancies. However, synchronous occurrence of gastric cancer (GC) and colonic cancer (CC) is a rare entity. A 41-year-old male came with complaints of epigastric pain associated with anorexia, rapid weight loss, and occasional constipation.

The Clinical Utility of Automated Immature Granulocyte Measurement in the Early Diagnosis of Bacteremia.

Background Early diagnosis and prompt management are crucial for bacteremia and sepsis, as they have the potential to lead to septic shock and fatal outcomes. Bacteremia induces the recruitment of immature granulocytes (IGs) into the circulation, which indicates active bone marrow response. The goal of our present study is to determine the effectiveness of automated IG measurement as an alternate indicator for infection and also its clinical utility in predicting positive blood culture (BC) results.