Publications by authors named "Lakshmi Savitala-Damerla"
Article Synopsis
- Detection of measurable residual disease (MRD) is crucial for predicting relapse and guiding treatment in adults with acute lymphoblastic leukemia (ALL), with next-generation sequencing (NGS) providing better sensitivity than traditional methods.
- This study compared MRD detection between NGS and flow cytometry (MFC) in 52 adult patients, finding that NGS was a more accurate predictor of relapse risk post-treatment.
- Results indicated that NGS could identify patients at higher risk of relapse, especially those initially deemed MRD negative by MFC, highlighting its potential to optimize adjuvant therapy decisions.
Background: Cytomegalovirus (CMV) infection significantly impacts the morbidity and mortality of patients undergoing allogeneic hematopoietic stem cell transplant (HSCT). Despite monitoring and pharmacologic prophylaxis with drugs such as valganciclovir or ganciclovir, rates of early CMV reactivation have continually persisted, contributing to increased rates of morbidity and mortality in allogeneic-HSCT patients. This study evaluates the outcomes of letermovir in preventing CMV reactivation and CMV-related complications in HSCT recipients with initiation of therapy at +21 days in high-risk patients.
View Article and Find Full Text PDF