Publications by authors named "Lakshmi Priyankka Alagappan"
Association of HERPUD1 genetic variant rs2217332 with age-related macular degeneration and polypoidal choroidal vasculopathy in an Indian cohort.
Graefes Arch Clin Exp Ophthalmol
April 2023
Article Synopsis
- The study investigates the relationship between the genetic variant rs2217332 in the HERPUD1 gene and two eye diseases: age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) in an Indian population.
- Researchers analyzed data from 422 participants, including patients with AMD, PCV, and healthy controls, using genetic sequencing and statistical analysis to assess associations.
- Results indicated a significant connection between rs2217332 and PCV, but not with AMD, suggesting that this genetic variant increases the risk specifically for PCV.
Background And Objectives: Polypoidal choroidal vasculopathy (PCV) is a retinal disorder characterized by the presence of aneurismal polypoidal lesions in the choroidal vasculature. A single nucleotide polymorphism (SNP) is a common genetic variant which may be associated with the disease. This study is to investigate the association of HERPUD1 (rs2217332) gene with PCV in the Indian population and develop an automated system for genotype and phenotype correlation using fundus images and machine learning methods.
View Article and Find Full Text PDFIncreased consumption of raw and par-boiled rice results in the formation of methylglyoxal (MG) at higher concentration and leads to complications in diabetic patients. Highly sensitive electrochemical biosensor was developed using glutathione (GSH) as a co-factor with vanadium pentoxide (VO) as a nano-interface for MG detection in rice samples. The Pt/VO/GSH/Chitosan bioelectrode displayed two well-defined redox peaks in its cyclic voltammograms for MG reduction.
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