Publications by authors named "Lakshmi Kalyani Ruddaraju"

Liposomes are well-recognized and essential nano-sized drug delivery systems. Liposomes are phospholipid vesicles comprised of cell membrane components and have been employed as artificial cell models to mimic structure and functions of cells and are of immense use in various biological analyses. Liposomes acquire great advantages and provide wide range of applications as useful drug carriers in pre-clinical and clinical trials.

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In the primitive era, humans benefited partially from plants and metals to treat microbial infections. Later these infections were cured with antibiotics but further suffered from resistance issues. In searching of an alternative, researchers developed an adjuvant therapy but were hampered by spreading resistance.

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The aim of the work is to synthesize iron oxide (α-FeO) nanoparticles using plant extract along with evaluation of its antibacterial activity. The presence of phytochemicals in methanolic plant extract was investigated by HPTLC and LC-MS/TOF. The probable mechanism for formation of α-FeO nanoparticles in mediation with plant extract was demonstrated.

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Zinc Oxide (ZnO) is currently used in nano-cosmeceuticals and nano-pharmaceuticals topically due to their multifunctional efficiency irrespective of the synthetic method. Bio-reducers are cosmopolitically famed to attain stable, reliable, and toxic free synthesis. Thus, the objective of the current study is to prepare ZnO NPs in a greener approach using Annona squamosa (AS) leaf extract and to evaluate their antibiotic potentiation capacity and anticancer activity.

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The present study is focused on the synthesis of silver nano particles (Ag NPs) using an aqueous extract of the whole plant of Sida cordifolia as a potential bio-reducing agent and assessment of their antibacterial activity. UV-Vis spectroscopy of composed silver colloidal solution displayed surface Plasmon resonance peak at 420 nm. XRD and TEM analysis revealed the morphology as ultra-small, monodispersed spherical nanoparticles with face-centered cubic structure and mean particle size of 3-6 nm.

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The current research study focuses to formulate the biosynthesized silver nanoparticles for the first time from silver acetate using methanolic root extracts of Diospyros sylvatica, a member of family Ebenaceae. TEM analysis revealed the average diameter of Ag NPs around 8nm which is in good agreement with the average crystallite size (10nm) calculated from X-ray Diffraction (XRD) analysis. Further the study has been extended to the antimicrobial activity against test pathogenic Gram (+) ve, Gram (-) ve bacterial and fungal strains.

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