Diminishing toxicity of pyrene on photosynthetic performance of soybean using (NCIM 5594).

Polycyclic aromatic hydrocarbons are persistent organic pollutants causing serious environmental problems, being toxic to plants and difficult to remediate. Pyrene is one such extremely dangerous compound that is toxic for the environment. This study suggests the use of Bacillus subtilis (National Collection of Industrial Microorganisms [NCIM] 5594) to overcome inhibitory effects of pyrene on soybean photosynthesis.

High Prevalence of NRTI and NNRTI Drug Resistance Among ART-Experienced, Hospitalized Inpatients.

Background: Patients hospitalized with advanced HIV have a high mortality risk. We assessed viremia and drug resistance among differentiated care services and explored whether expediting the switching of failing treatments may be justified.

Setting: Hospitals in the Democratic Republic of (DRC) Congo (HIV hospital) and Kenya (general hospital including HIV care).

Decline in Hepatitis C Virus (HCV) Incidence in Men Who Have Sex With Men Living With Human Immunodeficiency Virus: Progress to HCV Microelimination in the United Kingdom?

Background: Modeling of the London hepatitis C virus (HCV) epidemic in men who have sex with men (MSM) and are living with human immunodeficiency virus (HIV) suggested that early access to direct-acting antiviral (DAA) treatment may reduce incidence. With high rates of linkage to care, microelimination of HCV within MSM living with HIV may be realistic ahead of 2030 World Health Organization targets. We examined trends in HCV incidence in the pre- and post-DAA eras for MSM living with HIV in London and Brighton, United Kingdom.

Protection of PSI and PSII complexes of wheat from toxic effect of anthracene by Bacillus subtilis (NCIM 5594).

Contamination of polycyclic aromatic hydrocarbons (PAHs) in environment indicates a serious problem to the present era. These are carcinogenic and mutagenic compounds and pose a potential risk to photosynthetic organisms. The present study illustrates the protection of Photosystem I and Photosystem II complexes of wheat plant by Bacillus subtilis (NCIM 5594) from toxic effects of anthracene (ANT).

Iatrogenic Cushing's syndrome due to drug interaction between glucocorticoids and the ritonavir or cobicistat containing HIV therapies.

Ritonavir and cobicistat, used as pharmacokinetic enhancers in combination with some antiretrovirals (ARVs) for the treatment of HIV, are potent inhibitors of the CYP3A4 isoenzyme. Most glucocorticoids are metabolised via the CYP3A4 pathway and iatrogenic Cushing's syndrome (ICS), with possible secondary adrenal insufficiency (SAI), is a recognised complication following co-administration with ritonavir or cobicistat. A structured approach for identifying and managing potentially affected individuals has not been established.

The efficacy and tolerability of voriconazole in the treatment of chronic cavitary pulmonary aspergillosis.

Voriconazole is the second oral drug licensed for the treatment of aspergillosis. A retrospective non-comparative study was conducted in 16 patients with chronic cavitary pulmonary aspergillosis (CCPA) treated with voriconazole. All patients had failed or were intolerant of itraconazole.