Interaction studies unveil potential binding sites on bovine serum albumin for gut metabolite trimethylamine n-oxide (TMAO).

Trimethylamine-N-oxide (TMAO) is gut microbiota-derived metabolite, plays a critical role in human health and diseases such as metabolic, cardiovascular, colorectal cancer and, neurological disorders. Binding interactions between TMAO and serum albumins are crucial to understand the impact of TMAO on disease mechanisms. However, detailed insights into the interaction mechanisms, preferred binding locations, and conformational changes in BSA upon binding TMAO are still unclear.

Optical tuning of polymer functionalized zinc oxide quantum dots as a selective probe for the detection of antibiotics.

Excess consumption of antibiotics leads to antibiotic resistance that hinders the control and cure of microbial diseases. Therefore, it is crucial to monitor the antibiotic levels in the environment. In this proposed research work, an optical nano-sensor was devised that can sense the ultra-low concentration of antibiotics, in samples like tap water using fluorescent zinc oxide quantum dots (ZnO QDs) based nano-sensor.

An electrochemical immunosensor based on a nano-ceria integrated microfluidic chip for interleukin-8 biomarker detection.

Interleukin-8 (IL8) is an important cytokine that plays a significant role in tumor growth and angiogenesis across various malignant tumors, including oral squamous cell carcinoma (OSCC). It is an important biomarker for oral cancer; therefore, its early and accurate detection in bodily fluid reduces morbidity and mortality rates in cancer patients. The work presents the development of a label-free microfluidic miniaturized electrochemical immunosensor for IL8 biomarker detection at low concentration in saliva samples.

Harnessing the UiO-67 metal-organic framework for advanced detection of cadmium ions in water bodies.

Heavy metal ions are hazardous pollutants that pose serious threats to ecosystems and human health, making it imperative to detect and monitor their presence in water for environmental protection. This paper highlights the synthesis of the UiO-67 Metal-Organic Framework (MOF) without any dopants, offering a novel approach specifically for the detection of cadmium ions (Cd) in aqueous environments. Following solvothermal synthesis, Powder X-ray Diffraction (PXRD), BET nitrogen adsorption-desorption analysis, X-ray Photoelectron Spectroscopy (XPS), and Scanning Electron Microscopy (SEM) were used to characterize the structural and morphological features of UiO-67.

The Influence of Glycemic Control Over Post-extraction Healing in Diabetic Patients.

Background Diabetes mellitus hinders wound healing after tooth extractions due to hyperglycemia, causing complications like infections and delayed recovery. The precise role of glycemic control in healing remains uncertain. This study aims to clarify it by comparing outcomes in patients with well-controlled and poorly controlled blood sugar levels.

Quantitative assessment and genomic profiling of dynamics in poultry processing: a case study in the United Arab Emirates integrated abattoir system.

In the United Arab Emirates, no previous research has investigated the dynamics of the foodborne pathogen in broiler abattoir processing. This study conducted in one of the largest poultry producers in the UAE, following each key slaughter stage-defeathering, evisceration, and final chilling-five broiler carcasses were collected from 10 slaughter batches over a year. Additionally, one caecum was obtained from 15 chickens in each slaughter batch to evaluate the flock colonization.

A One Health Perspective on Camel Meat Hygiene and Zoonoses: Insights from a Decade of Research in the Middle East.

The purpose of this review was to investigatethe microbial and chemical safety of camel meat and the zoonotic diseases associated with camels in the Middle East over the past decade, emphasizing the crucial role of a One Health approach. By systematically analyzing recent studies (in the past decade, from 2014), we assessed pathogen prevalence, contamination with heavy metals and pesticide residues, and the impact of zoonotic diseases like Middle East respiratory syndrome coronavirus (MERS-CoV). The findings revealed significant variability in pathogen prevalence, with the frequent detection of traditional foodborne pathogens (e.

Trimethylamine N-oxide detection by electrochemical sensor based on screen printed electrode modified with molecularly imprinted polypyrrole-molybdenum(III) sulfide nanosheets.

Trimethylamine N-oxide (TMAO) is a gut metabolite produced by dietary L-carnitine and choline metabolism. Its altered level in the serum has been implicated in human health and diseases such as colorectal cancer, chronic kidney diseases, cardiovascular diseases, etc. Early detection of TMAO in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases.

spp. in Salad Vegetables: Biodiversity, Antimicrobial Resistance, and First Identification of Methicillin-Resistant Strains in the United Arab Emirates Food Supply.

Contamination of leafy greens with spp. can occur at various supply chain stages, from farm to table. This study comprehensively analyzes the species diversity, antimicrobial resistance, and virulence factors of in salad vegetables from markets in the United Arab Emirates (UAE).

Genomics Characterization of Colistin Resistant from Chicken Meat-the First Report in the United Arab Emirates.

Plasmid-mediated colistin resistance is an emerging One Health challenge at the human-food-environment interface. In this study, 12 colistin-resistant carrying gene were characterized using whole-genome sequencing. This is the first report from locally produced chicken meat in the United Arab Emirates.

Formation of partially embedded Au nanostructures: Ion beam irradiation on thin film.

The Au partially embedded nanostructure (PEN) is synthesized by ion irradiation on an Au thin film deposited on a glass substrate using a 50 keV Ar ion. Scanning electron microscopy results show ion beam-induced restructuring from irregularly shaped nanostructures (NSs) to spherical Au NSs, and further ion irradiation leads to the formation of well-separated spherical nanoparticles. Higuchi's algorithm of surface analysis is utilized to find the evolution of surface morphology with ion irradiation in terms of the Hurst exponent and fractal dimension.

Health-related quality of life in Parkinson's disease: systematic review and meta-analysis of EuroQol (EQ-5D) utility scores.

Introduction: Evaluating the Health-related quality of life (HRQoL) of individuals with Parkinson's disease (PD) holds significant importance in clinical and research settings. The EQ-5D is a widely recognized tool for comprehensive measurement of HRQoL using utility values. This study aims to systematically review and synthesize EQ-5D utility values from existing literature on patients with PD and their caregivers.

Genomic profiling of extended-spectrum β-lactamase-producing Escherichia coli from Pets in the United Arab Emirates: Unveiling colistin resistance mediated by mcr-1.1 and its probable transmission from chicken meat - A One Health perspective.

Background: The United Arab Emirates (UAE) has witnessed rapid urbanization and a surge in pet ownership, sparking concerns about the possible transfer of antimicrobial resistance (AMR) from pets to humans and the environment. This study delves into the whole-genome sequencing analysis of ESBL-producing E. coli strains from healthy cats and dogs in the UAE, which exhibit multidrug resistance (MDR).

Development of aptasensor for chlorpyrifos detection using paper-based screen-printed electrode.

Novel Carbon quantum dots-graphite composite ink-based Screen-printed electrodes (CQDs/SPEs) were used to assemble a highly sensitive electrochemical aptasensor against chlorpyrifos (CPF). The aptasensor showed a broad linear range from 1 pM (0.445 ng/ml) to 500 nM (0.

Assessing the Prevalence and Potential Risks of Infection Associated with Fresh Salad Vegetable Consumption in the United Arab Emirates.

This study aimed to investigate the occurrence and characteristics of isolates in salad vegetables in the United Arab Emirates (UAE). Out of 400 samples tested from retail, only 1.25% (95% confidence interval, 0.

Emergence and Genomic Characterization of the First Reported -Carrying Linezolid-Resistant Enterococci Isolated from Retail Broiler Meat in the United Arab Emirates.

The foodborne transfer of resistant genes from enterococci to humans and their tolerance to several commonly used antimicrobials are of growing concern worldwide. Linezolid is a last-line drug for managing complicated illnesses resulting from multidrug-resistant Gram-positive bacteria. The gene has been reported in enterococci as one of the acquired linezolid resistance mechanisms.

Contamination Levels and Phenotypic and Genomic Characterization of Antimicrobial Resistance in Isolated from Fresh Salad Vegetables in the United Arab Emirates.

Contaminated fresh produce has been identified as a vehicle for human foodborne illness. The present study investigated the counts, antimicrobial resistance profile, and genome-based characterization of in 11 different types of fresh salad vegetable products ( = 400) sampled from retailers in Abu Dhabi and Dubai in the United Arab Emirates. was detected in 30% of the tested fresh salad vegetable items, with 26.

Domestic Pets in the United Arab Emirates as Reservoirs for Antibiotic-Resistant Bacteria: A Comprehensive Analysis of Extended-Spectrum Beta-Lactamase Producing Prevalence and Risk Factors.

Extended-spectrum β-lactamases resistant (ESBL-R) () has been reported from healthy and sick pets. However, data from Middle Eastern countries, including the United Arab Emirates (UAE), are minimal. This study provides the first evidence of ESBL-R carriage among pets in the UAE.

Genomic characterization of molecular markers associated with antimicrobial resistance and virulence of the prevalent isolated from retail chicken meat in the United Arab Emirates.

is a major cause of gastroenteritis worldwide, with broiler meat accounting for most illnesses. Antimicrobial intervention is recommended in severe cases of campylobacteriosis. The emergence of antimicrobial resistance (AMR) in is a concerning food safety challenge, and monitoring the trends of AMR is vital for a better risk assessment.

Optimal placement of distributed generation based on DISCO's financial benefit with loss and emission reduction using hybrid Jaya-Red Deer optimizer.

The optimal location of distributed generation (DG) is a critical challenge for distribution firms in order to keep the distribution network running smoothly. The optimal placement of DG units is an optimization challenge in which the objective function is to maximize distribution firms' financial benefit owing to reduced active power losses and emissions in the network. Bus voltage limits and feeder thermal limits are considered as constraints.

Environmental friendly Polyacrylonitrile nanofiber mats encapsulated and coated with green algae mediated Titanium oxide nanoparticles for efficient oil spill adsorption.

Oil spill causes extreme environmental damage, from aquatic life to seabirds, disrupting the entire ecosystem. Herein, we have synthesized high scale, economical and bio-compatible, green algae mediated Titanium oxide (TiO) nanoparticles and Polyacrylonitrile (PAN) nanofiber mats. We have studied the effect of encapsulation and coating of TiO nanoparticles over nanofiber mats for highly efficient oil spill adsorption.