The unseen spread-Schnitzler's metastasis unveiled: a case report.

Metastasis to the rectum is very rare and is usually caused by primaries from the breast, gastrointestinal tract, and genitourinary system. We report here a case of acute intestinal obstruction caused by an unusual rectal stenosis, for which he underwent a diversion stoma. On extensive evaluation for the etiology of the rectal stenosis, he was diagnosed with diffuse gastric cancer with Schnitzler's metastasis to the rectal submucosa.

Lymphomas With Primary Gastrointestinal Presentation: A Retrospective Study Covering a Five-Year Period at a Quaternary Care Center in Southern India.

Background and objective Lymphomas can involve the gastrointestinal (GI) tract as a primary disease or as a secondary spread of systemic disease. The GI tract is a key site for extranodal lymphomas, with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) occurring in this region. This study aimed to analyze the demography, anatomic distribution, histological subtypes, and immunomorphological characteristics of all lymphomas with a primary GI presentation at a quaternary care hospital in southern India.

Anterolateral Thigh Flap for Abdominal Wall Defect After Debridement for Meleney's With Fournier's Gangrene: A Case Report of a Rare Outcome.

Meleney's gangrene is a synergistic polymicrobial infection of the anterior abdominal wall causing rapidly progressive necrotizing fasciitis of skin and subcutaneous tissues. When combined with Fournier's gangrene, the mortality rates are higher. Here, we discuss a case of Meleney's with Fournier's gangrene managed with appropriate antibiotics and extensive wound debridement, followed by a successful split-thickness skin grafting of the lower anterior abdominal wall and scrotum.

Effect of Flux and Co-doping on Photoluminescence Properties of ZnSiO:Eu Red Phosphors for Blue LED Excitable White LED Applications.

Eu activated ZnSiO red phosphor synthesized by pyrolysis technique at 1000ºC for one hour is reported. Upon excitation by 394 nm and 464 nm, the phosphor displays a distinct red emission peaking around 614 nm, a characteristic of f-f electronic transitions involving Eu ions.Incorporating alkali metal ions such as Li, Na and K into ZnSiO:Eu phosphor led to a remarkable increase in photoluminescence (PL) intensity.

Intense Red Fluorescence From Surface Traps in BaSO:V, Eu and Its Applications.

BaSO:V synthesized at 1000°C in air exhibits an intense emission band peaking at 495 nm from surface traps assisted by atmospheric oxygen on excitation at 350 nm due to charge transfer from O to V in the (VO) tetrahedral complex. BaSO:Eu synthesized under similar conditions exhibits both Eu (375 nm) and Eu (619 nm) fluorescence. Vanadium codoping quenches the Eu fluorescence but enhances the Eu fluorescence in BaSO:V, Eu due to charge compensation.

Synergistic optimization of thermoelectric properties in CuNiSnSe composited with CuO nanoparticles.

Quaternary chalcogenides have gained significant attention in thermoelectric (TE) material research for their high thermoelectric conversion efficiency. The present work investigates the optimisation of the thermoelectric performance of CuNiSnSe utilising the energy filtering effect through the incorporation of CuO into a host matrix. The impact of varying the weight percentage of CuO on the TE properties of the nanocomposite materials was studied and compared with that of pristine CuNiSnSe.

Deciphering Annona's Anticancer Potential: Comparative Analysis of Crude Extract Versus Nanoformulation on SCC-25 Oral Cancer Cells Through cell Viability, Apoptosis, Cell Cycle, ROS, and MMP Analysis.

Introduction: Annona muricata contains acetogenins, which have shown promising anticancer activity against various cell lines. This study aims to evaluate and compare the anticancer activity of the crude extract of Annona muricata and its nano formulation on Squamous Cell Carcinoma-25 (SCC-25) oral cancer cell lines.

Methods: The crude extract of Annona muricata was prepared using standard extraction techniques, while its nano formulation was synthesized through nanoparticle fabrication methods.

Simple and rapid flow cytometry assay for the detection of malignant epithelial cells in body fluids.

Introduction: Morphology is routinely used for detecting malignant cells in body fluids, but it has limitations. Recently, flow cytometry (FCM) is used as an effective tool for studying non-haematological malignancies. The main objective of this study is to standardize a simple and rapid FCM test for the detection of malignant epithelial cells in body fluids.

The impact of exclusive human milk diet on short-term growth of very preterm infants.

Objectives: The impact of exclusive human milk diet (EHMD) on postnatal growth remains controversial. This study aims to investigate the association between EHMD and short-term growth.

Methods: This multicenter retrospective study aims to compare growth between the EHMD and non-EHMD groups among infants <32 weeks of gestation.

Institutional and Regional Variation in Opioid Prescribing for Hospitalized Infants in the US.

Importance: High-risk infants, defined as newborns with substantial neonatal-perinatal morbidities, often undergo multiple procedures and require prolonged intubation, resulting in extended opioid exposure that is associated with poor outcomes. Understanding variation in opioid prescribing can inform quality improvement and best-practice initiatives.

Objective: To examine regional and institutional variation in opioid prescribing, including short- and long-acting agents, in high-risk hospitalized infants.

Current Trends and Challenges of Microbiome Research in Bladder Cancer.

Purpose Of The Review: Microbiome research has provided valuable insights into the associations between microbial communities and bladder cancer. However, this field faces significant challenges that hinder the interpretation, generalization, and translation of findings into clinical practice. This review aims to elucidate these challenges and highlight the importance of addressing them for the advancement of microbiome research in bladder cancer.

Uncertainty and the NICU Experience: A Qualitative Evaluation of Family and Provider Perspectives.

There is limited information regarding caregiver and provider perspectives on uncertainty across the continuum of the neonatal intensive care unit (NICU) experience. Open-ended semi-structured interviews were conducted with providers and English- and Spanish-speaking caregivers of infants with a history of admission to a quaternary safety-net NICU. Major themes were generated using inductive-deductive thematic analysis.

Ultrasonic reporters of calcium for deep tissue imaging of cellular signals.

Calcium imaging has enabled major biological discoveries. However, the scattering of light by tissue limits the use of standard fluorescent calcium indicators in living animals. To address this limitation, we introduce the first genetically encoded ultrasonic reporter of calcium (URoC).

Differential Pharmacokinetic Interplay of Atorvastatin on Lacosamide and Levetiracetam on Experimental Convulsions in Mice.

Background: The beneficial effects of statins, other than their hypocholesterolemia role, have been well documented, however, their use as an adjuvant drug with other antiseizure drugs, in the treatment of epilepsy is poorly understood.

Objective: This study aimed to investigate the symbiotic effect of ATOR along with either lacosamide (LACO) or levetiracetam (LEVE) on experimentally induced epilepsy (Maximal electro-shock-MES or pentylenetetrazol- PTZ) in mice models.

Methods: Conventional elevated-maze (EPM) and rotarod methods were performed to observe the behavioral effects.

T1-/T2-weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy.

Short-range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age-matched controls and assessed relationships between myelin and aging.

Faricimab: Transforming the Future of Macular Diseases Treatment - A Comprehensive Review of Clinical Studies.

Degenerative eye conditions such as age-related macular degeneration (AMD), diabetic retinopathy, and retinal vein occlusion are major contributors to significant vision loss in developed nations. The primary therapeutic approach for managing complications linked to these diseases involves the intravitreal delivery of anti-vascular endothelial growth factor (VEGF) treatments. Faricimab is a novel, humanised, bispecific antibody that simultaneously binds all VEGF-A isoforms and Angiopoietin-2, which has been approved by regulatory agencies, such as the US Food and Drug Administration (FDA), the UK Medicines and Healthcare products Regulatory Agency (MHRA) and the European Medicines Agency (EMA), for the treatment of neovascular AMD and diabetic macular oedema (DMO).

Current Trends in Invasive Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants in United States Children's Hospitals, 2016-2021.

Objective: To describe the current practices in invasive patent ductus arteriosus (PDA) closure (surgical ligation or transcatheter occlusion) in very low birth weight (VLBW) infants and changes in patient characteristics and outcomes from 2016 to 2021 among US children's hospitals.

Study Design: We evaluated a retrospective cohort of VLBW infants (birth weight 400-1499 g and gestational age 22-31 weeks) who had invasive PDA closure within 6 months of age from 2016 to 2021 in children's hospitals in the Pediatric Health Information System. Changes in patient characteristics and outcomes over time were evaluated using generalized linear models and generalized linear mixed models.