Publications by authors named "Lakshi A Dayarathne"
extract (SPE) is a highly consumable seafood worldwide with known health-related benefits. However, there are no reports of its' anti-obesity effect. This study explores the potential of SPE for anti-obesity effects by modulating adipogenesis and lipolysis.
View Article and Find Full Text PDFThe current study aimed to determine whether () extract (SIE) exerts anti-obesity potentials employing 3T3-L1 cells as in vitro model. Herein we reported that treatment of SIE for 6 days reduced lipid accretion and triglyceride content whereas it increased the release of free glycerol. The inhibited lipid accumulation and induced lipolysis were evidenced by the downregulation of lipogenesis proteins, such as fatty acid synthase and lipoprotein lipase, and the upregulation of hormone-sensitive lipase expression.
View Article and Find Full Text PDFThe present study aims to explore the probable anti-adipogenesis effect of () in 3T3-L1 preadipocytes by regulating heme oxygenase-1 (HO-1). The extract of retarded lipid accretion and decreased triglyceride (TG) content in 3T3-L1 adipocytes but increased free glycerol levels. Treatment with the extract inhibited lipogenesis by inhibiting protein expressions of fatty acid synthase (FAS) and lipoprotein lipase (LPL), whereas lipolysis increased by activating phosphorylation of hormone-sensitive lipase (p-HSL) and AMP-activated protein kinase (p-AMPK).
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- This study investigates how hesperidin (HES) affects diabetes management by analyzing gene expression in high fat diet (HFD)-induced obese mice.
- It was found that HES treatment improved glucose uptake, decreased blood glucose and insulin levels, and enhanced both glucose and insulin tolerance to normal levels.
- Additionally, RNA sequencing revealed that HES restored the expression of key genes involved in insulin signaling and glucose metabolism, contributing to its potential anti-diabetic properties.
Article Synopsis
- Flavonoids, natural compounds found in citrus fruits, have shown promise in reducing fat cell formation (anti-adipogenic effects), although the exact mechanisms remain unclear.
- This study focused on five main citrus flavonoids (hesperidin, narirutin, nobiletin, sinensetin, and tangeretin) to examine their impact on AMPK activation in liver cells treated with palmitate.
- Results indicated that these flavonoids decreased fat accumulation, increased glucose uptake, and activated key proteins involved in fat metabolism, suggesting they could be effective activators of AMPK, which may help reduce fat buildup in cells.
Article Synopsis
- Naringin and naringenin, flavonoids from citrus fruits, have potential anti-diabetic effects, but their mechanisms are not fully understood.
- This study focused on how these compounds affect glucose uptake through AMPK phosphorylation in HepG2 cells treated with high glucose.
- Results showed that both naringin and naringenin boost glucose uptake by promoting AMPK activation and GSK3β phosphorylation, regardless of insulin presence, with naringin having a particularly strong binding affinity to AMPK.
Article Synopsis
- * Methods included measuring lipid accumulation, triglyceride content, glucose uptake, and analyzing gene expression changes in 3T3-L1 adipocytes treated with these flavonoids.
- * Findings suggested that both compounds significantly reduce lipid accumulation and alter the expression of key genes in lipid metabolism, indicating their potential as anti-obesity agents.