Publications by authors named "Lakdhar Ghazouani"
Article Synopsis
- A study investigated how certain human platelet antigen (HPA) variants relate to the risk of coronary artery disease (CAD) in a group of 341 patients compared to 316 control subjects.
- HPA-1b and HPA-3b alleles, along with specific HPA haplotypes, were found to be more common in CAD patients, suggesting a link to increased disease susceptibility.
- The analysis indicated that HPA-1b/2a/3b and HPA-1b/2b/3a haplotypes significantly increased CAD risk, providing evidence for the genetic contribution to coronary artery disease in the Tunisian population.
Objectives: Insofar as platelet membrane glycoprotein (GP) polymorphisms were identified as potential risk factors for coronary artery disease (CAD), we investigated the contribution of human platelet antigen (HPA)-1 (GPIIb/IIIa) and HPA-2 (GPIb/IX) alleles and haplotypes to CAD pathogenesis.
Methods: Study subjects comprised 247 middle-age CAD patients and 316 age-, gender-, and race-matched controls; HPA genotyping was performed by polymerase chain reaction with sequence specific primers.
Results: The frequencies of HPA-1b (P<.