Publications by authors named "Laiza S Biano"
Background: Cutaneous Leishmaniasis (CL) is a neglected tropical disease endemic in Brazil. Morbidity and disabilities caused by CL lesions require an analysis of a Global Burden of Disease (GBD), which would help discern the impact on the Brazilian population. Herein, we assess the burden of CL and its spatial and temporal patterns in Brazil between 2001 and 2021.
View Article and Find Full Text PDF: Wound healing relies on a coordinated process with the participation of different mediators. Natural products are a source of active compounds with healing potential. Isoorientin is a natural flavone recognized as having several pharmacological properties, such as anti-inflammatory effects, making it a potential treatment for wounds.
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- The study investigates the antinociceptive (pain-relieving) effects of ethanol extract from rambutan fruit peel (EENL) and its safety profile using zebrafish and mice models.
- Researchers identified key compounds like (epi)-catechin and ellagic acid in EENL and found no toxicity in zebrafish embryos.
- The extract showed significant pain reduction in mice through mechanisms involving opioid receptors, nitric oxide, and KATP channels, without affecting their locomotor activity.
Ethnopharmacological Relevance: Leonurus sibiricus L. (Lamiaceae) is a medicinal plant known in Brazil as "rubim" or "erva de macaé". It is used for various purposes, including stomach disorders.
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