Publications by authors named "Laise Nayana Sala Elpidio"
Article Synopsis
- Leprosy is a chronic disease and significant global health issue, with new cases reported annually; this study investigates genetic variants associated with susceptibility and protection against the disease.
- A case-control design involving 183 leprosy patients and 185 controls in southern Brazil was used to analyze specific genetic polymorphisms, identifying different frequencies in the control group that suggest a protective effect.
- Results indicate that certain genetic polymorphisms (such as rs5743618, rs1816702, and rs4696483) are linked to resistance or susceptibility to leprosy, highlighting the role of T and C alleles in influencing risk and protection.
Background: Zika virus (ZIKV) is an emerging arbovirus associated with foetal malformations and neurological complications. The infection is usually associated with mild symptoms. The comparison between the allelic frequency of polymorphic genes in symptomatic infected individuals in the population can clarify the pathogenic mechanisms of ZIKV.
View Article and Find Full Text PDFDuring the 2015-2016 epidemic, Brazil was the country with the highest rate of Zika virus (ZIKV) infection in the Americas. Twenty-nine percent of pregnant women positive for ZIKV exhibited ultrasound scans with fetus anomalies. Human leukocyte antigen-G (HLA-G) exerts immunoregulatory effects by binding to inhibitory receptors, namely LILRB1 and LILRB2, thus preventing mother-fetus rejection and vertical pathogen transmission.
View Article and Find Full Text PDFUnlabelled: Polycystic ovary syndrome (PCOS) affects the endocrine system and is associated with low-grade inflammation. Natural killer (NK) cells are involved in the defense of the female reproductive tract, folliculogenesis, ovulation and the menstrual cycle. The killer-cell immunoglobulin-like receptors (KIR) on the surface of NK cells modulate the activation and function of these cells after interacting with human leukocyte antigen (HLA) class I ligands.
View Article and Find Full Text PDFBackground: Polycystic ovary syndrome (PCOS) is the endocrinopathy that affects women in their reproductive age. The physiopathology involves multifactorial mechanisms, including cytokine gene regulation.
Methods: The review was conducted in the database PubMed, with articles published between 2005 and 2015.