Publications by authors named "Laise Lee"
Role of tau deposition in early cognitive decline in Down syndrome.
Alzheimers Dement (Amst)
April 2022
Article Synopsis
- - The study investigated the relationship between tau PET biomarker [F]AV-1451 and episodic memory issues in adults with Down syndrome, building on the amyloid/tau/neurodegeneration (AT[N]) model.
- - Researchers analyzed data from 123 non-demented adults with Down syndrome, using various memory tests and tau and amyloid beta PET assessments to gauge their cognitive performance.
- - Results showed that high tau levels were linked to poorer episodic memory, particularly in participants with elevated amyloid beta, indicating that high tau could signal early signs of Alzheimer's disease in individuals with Down syndrome.