Publications by authors named "Laise Adriane Hegeto"
The activity of rifampin (RIF) and piperine was evaluated at the relative transcript levels of 12 efflux pumps (EPs), and an additional mechanism was proposed to be behind the synergic interactions of piperine plus RIF in AutoDock v4.2.3 and Molegro v6 programs were used to evaluate PIP binding in RNA polymerase (RNAP).
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- Piperine, derived from Piper nigrum and Piper longum, has potential as an efflux pump inhibitor and a complementary treatment for tuberculosis (TB).
- The systematic review analyzed studies on piperine's effects against mycobacteria, focusing on its mechanisms, drug interactions, and antimycobacterial properties.
- Out of 225 articles identified, eight met the inclusion criteria and indicated that piperine exhibits effective anti-TB activity, particularly when used alongside other antimicrobials.
Tuberculosis (TB) is an important public health problem worldwide and the emergence of multidrug-resistant (MDR) TB and extensively drug-resistant (XDR) TB worsened the global context. The resistance in Mycobacterium tuberculosis, the causative agent of TB, can partially derive from efflux pumps (EPs) activity in plasma membrane. Due to the recent discovery of piperine (PIP), an organic alkaloid compound, increasing the bioavailability of various drugs, the current assay evaluated the combined activity of PIP and anti-TB drugs in susceptible and resistant M.
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