Publications by authors named "Laisa Camerini"
Article Synopsis
- Childhood trauma negatively affects mental health and can be passed down to future generations, impacting the emotional and behavioral issues of children.
- The study analyzed 310 preschool-aged children to see how maternal childhood trauma interacted with genetic factors, specifically the COMT ValMet variant, and assessed behavioral problems using established questionnaires.
- Results showed that while maternal trauma generally increases behavioral issues in children, those with the Val/Met genotype are less prone to certain problems compared to those with other genetic variants, highlighting the importance of both trauma and genetics in child development.
Article Synopsis
- The study explores how cortisol and oxytocin levels change during pregnancy, focusing on a cohort of pregnant women in Southern Brazil.
- Researchers found that cortisol levels increase exponentially as pregnancy progresses, starting at an average of 44.2 μg/dl in the first week and rising by about 2% weekly.
- In contrast, oxytocin levels did not show significant changes throughout the studied period, indicating a need for further research to understand its variability during pregnancy.
Identifying genetic variants associated with side effects of antidepressant treatment: A systematic review.
Prog Neuropsychopharmacol Biol Psychiatry
October 2024
Article Synopsis
- Major Depressive Disorder (MDD) is highly prevalent worldwide, and antidepressant medications are commonly used to manage its symptoms, but side effects can lead to reduced patient adherence.
- Research suggests that genetic variations (polymorphisms) may influence these side effects, prompting a systematic review to investigate this association across 55 studies.
- The review found that polymorphisms in 35 specific genes were linked to antidepressant side effects, and a Protein-Protein Interaction Network analysis was conducted to identify biological pathways, suggesting future potential for pharmacogenetic markers in treatment.
Article Synopsis
- Previous research shows a connection between childhood maltreatment and the development of ADHD, but the interaction between genetic predisposition and maltreatment's effects on ADHD symptoms is still not fully understood.
- This study analyzed data from a large Brazilian birth cohort to investigate the relationship between a polygenic score for ADHD and childhood maltreatment in predicting ADHD symptoms in young adults.
- The results indicated that both genetic factors and childhood maltreatment significantly correlate with ADHD symptoms, with childhood maltreatment partially mediating the relationship between genetic predisposition and ADHD outcomes, though no direct gene-environment interaction was found.
Temperament traits mediate the relationship between CACNA1C polymorphisms and bipolar disorder in cisgender women.
Eur Arch Psychiatry Clin Neurosci
February 2023
Article Synopsis
- Research explored how temperament traits impact bipolar disorder (BD) and their connection to genetic variations in the CACNA1C gene, particularly in relation to biological sex.
- A study of 878 Caucasian individuals aged 18-35 in Brazil found that certain temperament traits mediated the relationship between specific genetic polymorphisms and BD, particularly in women.
- The results suggested that temperament traits function as endophenotypes for BD in females, but no effects were observed in cisgender men, highlighting a sex-specific interaction in the genetic-temperament-BD link.
Article Synopsis
- * It focused on two specific genetic variants: OXTR rs2254298, which was identified as a risk factor for both ADHD and anxiety, and CD38 rs6449182, associated with ADHD risk.
- * The findings offer insights into the genetic factors influencing developmental and behavioral disorders, highlighting the need for further research to better understand their underlying neurobiology in children.
Article Synopsis
- The study investigates the relationship between the COMT Val Met polymorphism and depression among young adults in Pelotas, Brazil, without finding a direct link to depression itself.
- It reveals that the Met-allele of the Val Met polymorphism significantly affects the impact of childhood trauma on depression risk, specifically in men who experienced trauma.
- The findings suggest that childhood trauma combined with genetic factors could influence gene regulation related to depression susceptibility, highlighting a complex interplay between genetics and early life experiences in mental health outcomes.
Article Synopsis
- The CACNA1C gene is linked to psychiatric disorders through its role in regulating BDNF levels via calcium channels.
- The study examined the impact of specific genetic polymorphisms (rs1006737 and rs4765913) on BDNF levels in 641 young adults, focusing on possible differences between sexes.
- Results showed that these polymorphisms influenced BDNF levels differently in men and women, suggesting gender-specific biological mechanisms that could help explain the link between CACNA1C and psychiatric conditions.
Chitosan films containing distilled pyroligneous extracts of Eucalyptus grandis (DPEC), characterized and developed by Brazilian Agricultural Research Corporation-Embrapa Temperate Agriculture (EMBRAPA-CPACT), were evaluated for antimicrobial activity against Candida albicans, Streptococcus mutans, and Lactobacillus acidophilus by direct contact test. Further, their capacity for the prevention of teeth enamel demineralization and cytotoxicity in vitro were also determined. The natural polymers were tested at different concentrations (1500-7500 µg mL) and the formulation of an experimental fluoride varnish with antimicrobial activity was evaluated by direct contact test, whereas cytotoxicity was analyzed through the colorimetric MTT assay.
View Article and Find Full Text PDFThe role of CACNA1C gene and childhood trauma interaction on bipolar disorder.
Clarissa Ribeiro Bastos Luciana Tovo-Rodrigues Ana Paula Ardais Janaina Xavier Pamela Silva Vitória Salerno Laísa Camerini
Prog Neuropsychopharmacol Biol Psychiatry
July 2020
Article Synopsis
- The study investigated how childhood trauma interacts with specific genetic variations in the CACNA1C gene to affect susceptibility to bipolar disorder (BD) in young adults.
- Researchers found no direct link between the gene polymorphisms (rs1006737 and rs4765913) and BD diagnosis, but did observe that childhood trauma significantly impacted the influence of the rs4765913 polymorphism and the AA haplotype on BD susceptibility.
- Specifically, individuals carrying at least one A allele of the rs4765913 polymorphism or the AA haplotype who experienced childhood trauma were more likely to develop BD, highlighting the importance of both genetic and environmental factors in the risk of this complex disease.
Article Synopsis
- Bipolar Disorder involves extreme mood swings, including episodes of depression and mania.
- Treatment often relies on mood stabilizers that have significant side effects, prompting a search for new therapies.
- Inosine shows potential as it prevented increased locomotor activity in a rat model of mania, suggesting its possible role in managing manic symptoms in bipolar disorder.