Publications by authors named "Laisa Briongos"
Article Synopsis
- Osteoporosis and its complications are believed to stem from bone aging, environmental influences, and genetic factors, with oxidative stress playing a critical role in age-related bone issues.
- This study analyzed genetic variants related to oxidative stress in 221 patients with osteoporosis and 354 controls over a 12-14 year period.
- Key findings indicated that the SNP rs4077561 in the TXNRD1 gene significantly increases fracture risk, alongside other SNPs in related genes like M6PR and GPX6, highlighting the importance of genetic predisposition in osteoporosis.
Article Synopsis
- The study aimed to identify metabolomic and genomic markers linked to clusters of cardiometabolic risk factors (CMRFs) in a general population of 1,502 Caucasian adults over 18 years old.
- The researchers measured blood pressure, body measurements, metabolic markers, and analyzed 1,251 SNPs while assessing serum metabolomic profiles, finding distinct metabolic differences among subjects grouped by the number of CMRFs.
- Key findings included that specific genotypes (rs174577 and rs3803) were associated with lower prevalence of hypertension and Type 2 Diabetes Mellitus (T2DM) in individuals with three or more CMRFs, suggesting a link between genetic factors and CMRF clustering patterns.
Atraumatic subtrochanteric and diaphyseal (atypical) femoral fractures are a rare, but important adverse event in patients treated with potent anti-resortive agents. The mechanisms involved are unknown and particularly the association with genetic variants has not been explored. The aim of the study was to identify rare genetic variants that could be associated with the occurrence of these fractures.
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- The study aimed to identify factors linked to the development of microalbuminuria by analyzing genomic and metabolomic data from a sample of 1,502 Caucasian subjects over 18 years old.
- A total of 1,217 subjects were examined, revealing a unique metabolomic profile in those with microalbuminuria that included specific metabolic products and branched amino acids.
- The analysis highlighted two significant SNPs: the rs10492025_TT of the RPH3A gene, which may increase the risk, and the rs4359_CC of the ACE gene, which may decrease the risk of developing microalbuminuria, with age being a distinguishing factor among individuals sharing the same genotype and metabolomic profile.