Publications by authors named "Lais S K Marques"
Article Synopsis
- Clozapine is a second-generation antipsychotic recognized as the best treatment for patients with treatment-resistant schizophrenia, though it can cause severe side effects like neutropenia and rare cases of severe anemia associated with pure red cell aplasia (PRCA).
- The case study focuses on a 35-year-old man with treatment-resistant schizophrenia who developed severe anemia from clozapine, but after stopping the drug, his hemoglobin levels recovered.
- Following unsuccessful treatments with other antipsychotics, he was successfully rechallenged with clozapine for 58 days, showing improved psychiatric symptoms and stable hemoglobin, highlighting the importance of careful monitoring during such rechallenges and the need for more research on their outcomes.
This study evaluated both telomere length (TL) and micronucleus (MN) as indicators of genome instability in 40 anesthesiologists occupationally exposed to anesthetics and in 40 physicians without occupational exposure to anesthetics who were matched by age, sex, and lifestyle. Blood and buccal samples were collected from both groups at the same period. Anesthetic exposure assessment was performed.
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