Am J Physiol Heart Circ Physiol
December 2024
The porcine and human heart are remarkably similar in cardiac physiology and biochemistry. Translational research involving the porcine biomedical model is becoming increasingly applicable for the study of human cardiac function in health and disease. Presently, few protocols exist for collecting experimentally viable cardiac tissue from large animal models, particularly during neonatal maturation.
View Article and Find Full Text PDFBackground: The repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols.
Hypothesis And Objectives: Administration of gabapentin at 40 and 120 mg/kg PO q 12 h for 14 days will not alter serum biochemistry findings or cause adverse effects. Our objectives were to evaluate the effect of gabapentin on serum biochemistry, physical examination, and plasma pharmacokinetics of gabapentin.
Objective: To test the anesthetic effect of a bupivacaine liposome injectable suspension (BLIS), used in a multiple-dose manner for up to 5 consecutive days.
Study Design: Prospective, randomized, experimental study.
Animals: A total of 30 male and female Sprague-Dawley rats (Rattus norvegicus), aged 97 (75-130) days and weighing 337.
The symptoms of infectious diarrheal disease are mediated by a combination of a pathogen's virulence factors and the host immune system. is the leading bacterial cause of diarrhea worldwide due to its near-ubiquitous zoonotic association with poultry. One of the outstanding questions is to what extent the bacteria are responsible for the diarrheal symptoms via intestinal cell necrosis versus immune cell initiated tissue damage.
View Article and Find Full Text PDFLidocaine is commonly used in ruminants but has an anecdotal history of being toxic to goats. To evaluate lidocaine's effects on selected cardiopulmonary parameters. Isoflurane-anesthetized adult goats (n = 24) undergoing abdominal surgery received a loading dose of lidocaine (2.
View Article and Find Full Text PDFObjective: The study aimed to investigate the effect of varying pulse lengths of inhaled nitric oxide (iNO), and 2.5 hours of continuous pulse-delivered iNO on pulmonary gas exchange in anaesthetized horses.
Study Design: Experimental study.
Objective: To assess physiologic responses and plasma endothelin (ET)-1 concentrations associated with abrupt cessation of nitric oxide (NO) inhalation in isoflurane-anesthetized horses.
Animals: 6 healthy adult Standardbreds.
Procedures: Horses were anesthetized with isoflurane in oxygen and placed in dorsal recumbency.
Objective: To evaluate the effects of preoperative extradural morphine on the end-tidal isoflurane (Fe'ISO) concentration and on physiological variables in pigs undergoing abdominal surgery.
Study Design: Prospective, randomized, blinded study.
Animals: Fourteen healthy pigs (20 +/- 4 kg) undergoing intestinal cannulation.