Mobile Apps for Wound Assessment and Monitoring: Limitations, Advancements and Opportunities.

With the proliferation of wound assessment apps across various app stores and the increasing integration of artificial intelligence (AI) in healthcare apps, there is a growing need for a comprehensive evaluation system. Current apps lack sufficient evidence-based reliability, prompting the necessity for a systematic assessment. The objectives of this study are to evaluate the wound assessment and monitoring apps, identify limitations, and outline opportunities for future app development.

Rapid-Access Focused Treatment: Clinical Considerations for Brief Psychotherapy in Outpatient Psychiatry.

Demand for mental health treatment surged after the COVID-19 pandemic intensified existing issues of limited access to care and long wait times. Programs that deliver high-quality treatment in a brief format are appealing in that they could reduce wait times for care and increase the number of patients served. The Rapid-Access Focused Treatment (RAFT) program was developed with the overarching goals of delivering brief, evidence-informed interventions in a timely and patient-centered manner, reducing wait times, and improving access to psychiatric specialty services.

Osteoporosis management in Australian aged care facilities: a mixed method study.

Unlabelled: Osteoporosis is a common but sub-optimally managed disease amongst aged care residents. Pharmacists undertaking comprehensive medication reviews is one strategy to improve osteoporosis management. Analysis of pharmacist medication review recommendations has identified common clinical practice issues that can be addressed to optimise osteoporosis management for aged care residents.

Impacts of a DUF2207 Family Protein on Stress Tolerance Responses and Biofilm Formation.

Locus SMU.243 in was annotated as a member of the DUF2207 family proteins highly conserved in all bacteria but with unknown function. To investigate its role in physiology, a SMU.

Perceptions and practices of aged care pharmacists regarding osteoporosis management: a qualitative study.

Background: Osteoporosis is a common but sub-optimally managed disease among aged care residents. Although pharmacists are one of the key healthcare providers responsible for osteoporosis medication management there is limited research on their involvement.

Aim: This study explored the perceptions and practices of Australian pharmacists regarding osteoporosis management for aged care residents.

: Computer-Vision-Based Smartphone Application to Measure the Foot from Images and 3D Scans.

The foot is a vital organ, as it stabilizes the impact forces between the human skeletal system and the ground. Hence, precise foot dimensions are essential not only for custom footwear design, but also for the clinical treatment of foot health. Most existing research on measuring foot dimensions depends on a heavy setup environment, which is costly and ineffective for daily use.

Knock-out of N-glycolylneuraminic acid attenuates antibody-mediated rejection in xenogenically perfused porcine lungs.

Antibody-mediated rejection has long been known to be one of the major organ failure mechanisms in xenotransplantation. In addition to the porcine α1,3-galactose (α1,3Gal) epitope, N-Glycolylneuraminic acid (Neu5Gc), a sialic acid, has been identified as an important porcine antigen against which most humans have pre-formed antibodies. Here we evaluate GalTKO.

Pharmacist interventions in osteoporosis management: a systematic review.

Unlabelled: Internationally, there is an osteoporosis treatment gap, which pharmacists may assist in closing. This review identifies pharmacist interventions for improving osteoporosis management and evaluates their effectiveness. Pharmacist interventions are shown to improve osteoporosis management in terms of increasing investigation and treatment commencement and osteoporosis therapy adherence.

Simulation-optimization framework for the digital design of pharmaceutical processes using Pyomo and PharmaPy.

The problem of performing model-based process design and optimization in the pharmaceutical industry is an important and challenging one both computationally and in choice of solution implementation. In this work, a framework is presented to directly utilize a process simulator via callbacks during derivative-based optimization. The framework allows users with little experience in translating mechanistic ODEs and PDEs to robust, fully discretized algebraic formulations, required for executing simultaneous equation-oriented optimization, to obtain mathematically guaranteed optima at a competitive solution time when compared with existing derivative-free and derivative-based frameworks.

A comparison of traditional orthodontic polishing systems with composite polishing systems following orthodontic debonding.

Introduction: At the completion of treatment, the orthodontic practitioner's goal is to effectively remove all traces of adhesive and return enamel to its initial state. With the advent of new polishing systems being released each year, there may be one product that is superior to others.

Aim: The purpose of this study is to determine the efficacy of new polishing systems (in the last 5-10 years) used in general dentistry on enamel surface roughness following debond utilizing profilometery and scanning electron microscopy and compare them to established orthodontic polishing systems results.

Sensitivity to behavioral stress impacts disease pathogenesis in dystrophin-deficient mice.

Mutation to the gene encoding dystrophin can cause Duchenne muscular dystrophy (DMD) and increase the sensitivity to stress in vertebrate species, including the mdx mouse model of DMD. Behavioral stressors can exacerbate some dystrophinopathy phenotypes of mdx skeletal muscle and cause hypotension-induced death. However, we have discovered that a subpopulation of mdx mice present with a wildtype-like response to mild (forced downhill treadmill exercise) and moderate (scruff restraint) behavioral stressors.

Nickel and chromium ion release from coated and uncoated orthodontic archwires under different pH levels and exposure times.

Objectives: The purpose of this study was to determine and compare nickel and chromium ion release from traditional stainless steel and nickel titanium wires and newer esthetic archwires under different pH conditions, for different time intervals.

Methods: Ten pieces of 10-mm segments of five different orthodontic archwires were submerged in buffer solutions of pH 4.0, 5.

PharmaPy: An object-oriented tool for the development of hybrid pharmaceutical flowsheets.

Process design and optimization continue to provide computational challenges as the chemical engineering and process optimization communities seek to address more complex and larger scale applications. Software tools for digital design and flowsheet simulation are readily available for traditional chemical processing applications such as in commodity chemicals and hydrocarbon processing; however, tools for pharmaceutical manufacturing are much less well developed. This paper introduces, PharmaPy, a Python-based modelling platform for pharmaceutical manufacturing systems design and optimization.

Evaluating Manual Sampling Locations for Regulatory and Emergency Response.

Drinking water systems commonly use manual or grab sampling to monitor water quality, identify or confirm issues, and verify that corrective or emergency response actions have been effective. In this paper, the effectiveness of regulatory sampling locations for emergency response is explored. An optimization formulation based on the literature was used to identify manual sampling locations to maximize overall nodal coverage of the system.

Pig-to-baboon lung xenotransplantation: Extended survival with targeted genetic modifications and pharmacologic treatments.

Galactosyl transferase knock-out pig lungs fail rapidly in baboons. Based on previously identified lung xenograft injury mechanisms, additional expression of human complement and coagulation pathway regulatory proteins, anti-inflammatory enzymes and self-recognition receptors, and knock-down of the β4Gal xenoantigen were tested in various combinations. Transient life-supporting GalTKO.

Optimal sampling locations to reduce uncertainty in contamination extent in water distribution systems.

Drinking water utilities rely on samples collected from the distribution system to provide assurance of water quality. If a water contamination incident is suspected, samples can be used to determine the source and extent of contamination. By determining the extent of contamination, the percentage of the population exposed to contamination, or areas of the system unaffected can be identified.

Effect of specific non-pharmaceutical intervention policies on SARS-CoV-2 transmission in the counties of the United States.

Non-pharmaceutical interventions (NPIs) remain the only widely available tool for controlling the ongoing SARS-CoV-2 pandemic. We estimated weekly values of the effective basic reproductive number (R) using a mechanistic metapopulation model and associated these with county-level characteristics and NPIs in the United States (US). Interventions that included school and leisure activities closure and nursing home visiting bans were all associated with a median R below 1 when combined with either stay at home orders (median R 0.

Mobile Apps for Foot Measurement in Pedorthic Practice: Scoping Review.

Background: As the use of smartphones increases globally across various fields of research and technology, significant contributions to the sectors related to health, specifically foot health, can be observed. Numerous smartphone apps are now being used for providing accurate information about various foot-related properties. Corresponding to this abundance of foot scanning and measuring apps available in app stores, there is a need for evaluating these apps, as limited information regarding their evidence-based quality is available.

Application of PharmaPy in the digital design of the manufacturing process of an active pharmaceutical ingredient.

Flowsheet design and optimization constitute one of the key challenges in the chemical engineering and process optimization communities. Software tools for digital design and flowsheet simulation are readily available for traditional chemical processing problems such as distillation and hydrocarbon processing, however tools for pharmaceutical manufacturing are much less widely developed. This paper introduces, PharmaPy, a Python-based modelling platform for pharmaceutical facility design and optimization.

Limited Role for Routine Restaging After Neoadjuvant Therapy in Locally Advanced Rectal Cancer.

Background: Although many patients with locally advanced rectal cancer undergo restaging imaging after neoadjuvant chemoradiotherapy and before surgery, the benefit of this practice is unclear. The purpose of this study was to examine the impact of reimaging on outcomes.

Materials And Methods: We performed a retrospective analysis of consecutive patients with stage 2 and 3 rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy between May 2005 and April 2018.

Trends in female surgeon authorship - The role of the middle author.

Background: The objective of this study was to compare middle authorships between male and female general surgeons in the United States.

Methods: A stratified random sample of American College of Surgeons general surgery fellows was identified. Relevant author demographic, affiliation, and publication metrics were collected and compared across cohorts to determine which demographics were prognostic for each outcome variable.

Strengthening care for children: pilot of an integrated general practitioner-paediatrician model of primary care in Victoria, Australia.

Objective The aim of this study was to assess the acceptability of a novel, integrated general practitioner (GP)-paediatrician model of care, aiming to reduce referrals to hospitals and improve primary care quality. Methods A pre-post study was conducted with five general practice clinics in north-west Melbourne. Over 12 months, 49 GPs and 896 families participated in the intervention that included weekly to fortnightly paediatrician-GP co-consultation sessions at the general practice, monthly case discussions and telephone or email clinical support for GPs.

Evaluation of fosaprepitant-associated hypersensitivity reactions at a National Cancer Center.

Introduction: At our institution, an increased incidence of hypersensitivity reactions was reported following standardization of fosaprepitant as the preferred agent for the prophylaxis of chemotherapy induced nausea and vomiting (CINV) caused by highly emetogenic therapies. The purpose of this evaluation was to assess the incidence of systemic hypersensitivity reactions (HSRs) to fosaprepitant infusions compared to available literature.

Methods: This evaluation is a retrospective review of electronic health records of adult patients who received their first dose of fosaprepitant for CINV prophylaxis beginning January 1, 2017 through June 30, 2017 at the University of Colorado Cancer Center outpatient infusion center.