GLR36 Mutation of Casuarina equisetifoli Is Associated With a Decreased JA Response to Insect Feeding by Lymantria xylina.

Lymantria xylina is the most important defoliator, damaging the effective coastal windbreak tree species Casuarina equisetifolia. However, the underlying genetic mechanisms through which C. equisetifolia responds to L.

Solar driven enhanced adsorption of radioactive Cs and Sr from nuclear wastewater by chitosan-based aerogel embedded with prussian blue analog.

The rational use of solar energy to achieve photothermal conversion is an attractive strategy to promote the efficient removal of radioactive Cs and Sr from nuclear wastewater. Herein, a photothermal adsorbent of composite aerogel with three-dimensional porous structure is fabricated by integrating prussian blue analogues (PBAs) and straw biochar into the chitosan (CS) and waste leather scrap hydrolysate (WLSH) aerogel matrix (CS/WLSH/C/PBAs). The local heating effect generated by CS/WLSH/C/PBAs aerogel induce to generate steam, accelerating the enrichment of Cs and Sr in the solution, which increase their interaction with the CS/WLSH/C/PBAs and improves their adsorption rates and capacities.

Quantification and source apportionment of atmospheric oxidation capacity in urban atmosphere by considering reactive chlorine species and photochemical loss of VOCs.

Atmospheric oxidation capacity (AOC) reflects the potential of the atmosphere in converting primary pollutants into secondary aerosols and ozone (O). In this study, the AOC at an urban supersite in Wuhan, a megacity in central China, was quantified by considering the reactions of volatile organic compounds (VOCs) and carbon monoxide (CO) with atmospheric oxidants (OH, NO, O, and Cl). Photochemical loss of total VOCs (13.

Ansofaxine suppressed NSCLC progression by increasing sensitization to combination immunotherapy.

Introduction: Depression negatively impacts the prognosis of various cancers, including lung cancer, by influencing antitumor immune responses and impairing immune cell function. Antidepressants may modulate the tumor immune microenvironment, enhancing immunotherapy efficacy. However, the specific mechanisms remain unclear.

An Outbreak of Human Adenovirus Infection Among Children Post COVID-19 Pandemic in Southern China.

Human adenovirus (HAdV) is an important pathogen causing pediatric acute respiratory illness (ARI) before COVID-19 pandemic. Since January 2023, China has reported ARI outbreaks attributed to Mycoplasma pneumoniae and other respiratory viruses. In this study, a total of 276 737 pediatric patients with ARI were enrolled from January 2023 to April 2024.

Emerging bioengineering breakthroughs in precision diagnosis and therapy for endometriosis and adenomyosis.

Endometriosis and adenomyosis are debilitating gynecological conditions that severely affect the quality of life of women. Traditional diagnostic and treatment methods, including laparoscopic surgery and hormonal therapy, face significant limitations such as incomplete lesion detection, high recurrence rates, and adverse side effects. Emerging bioengineering technologies offer promising solutions for precise diagnosis and therapy of these diseases.

Association between muscular atrophy and mortality risk in patients with COPD: a systematic review.

Background: Muscular atrophy often can be seen at the end of stage in many chronic diseases. It will also negatively influence patients' outcomes. Different studies showed that the association between muscular atrophy and mortality in patients with chronic obstructive pulmonary disease (COPD) was unclear.

The design and development of LRRK2 inhibitors as novel therapeutics for Parkinson's disease.

Parkinson's disease (PD) is a common neurodegenerative disease affecting nearly 10 million people worldwide and placing a heavy medical burden on both society and families. However, due to the complexity of its pathological mechanisms, current treatments for PD can only alleviate patients' symptoms. Therefore, novel therapeutic strategies are urgently sought in clinical practice.

Recent advances in nanomaterials for the detection of mycobacterium tuberculosis (Review).

The world's leading infectious disease killer tuberculosis (TB) has >10 million new cases and ~1.5 million mortalities yearly. Effective TB control and management depends on accurate and timely diagnosis to improve treatment, curb transmission and reduce the burden on the medical system.

Open-Source Anaerobic Digestion Modeling Platform, Anaerobic Digestion Model No. 1 Fast (ADM1F).

An open-source modeling platform, called Anaerobic Digestion Model No. 1 Fast (ADM1F), is introduced to achieve fast and numerically stable simulations of anaerobic digestion processes. ADM1F is compatible with an iPython interface to facilitate model configuration, simulation, data analysis, and visualization.

Integration of online and offline teaching mode in biochemistry and molecular biology courses.

To enhance the effectiveness of integrating online and offline teaching, 1545 clinical and preventive medicine students from 2019 to 2021 were randomly allocated to two groups, A and B. The curriculum was divided into two segments. Initially, two groups were established for the first segment, covering an introduction to Biomolecular and Material Metabolism.

Preparation and Characterization of C-Reactive Protein Dual-Particle Latex-Enhanced Immunoturbidimetric Reagents.

This study aims to couple C-reactive protein (CRP) antibodies onto latex spheres of 2 different sizes to enhance the accuracy and sensitivity of CRP detection. Furthermore, it seeks to establish a robust methodological framework crucial for advancing the development of latex-enhanced immunoturbidimetric detection reagents. CRP, an acute-phase protein, rapidly elevates in response to infections or tissue damage.

Revealing the Therapeutic Potential of Stem Cells in Burn Healing: A Deeper Understanding of the Therapeutic Mechanisms of Epidermal Stem Cells and Mesenchymal Stem Cells.

Burns are a global public health issue and a major cause of disability and death around the world. Stem cells, which are the undifferentiated cells with the potential for indefinite proliferation and multilineage differentiation, have the ability to replace injured skin and facilitate the wound repair process through paracrine mechanisms. In light of this, the present study aims to conduct a bibliometric analysis in order to identify research hotspots of stem cell-related burns and assess global research tendencies.

The role of ferroptosis-related non-coding RNA in liver fibrosis.

Liver fibrosis represents a reversible pathophysiological process, caused by chronic inflammation stemming from hepatocyte damage. It delineates the initial stage in the progression of chronic liver disease. This pathological progression is characterized by the excessive accumulation of the extracellular matrix (ECM), which leads to significant structural disruption and ultimately impairs liver function.

Fractional Carbon Dioxide Laser Combined with Secukinumab in the Treatment of Refractory Psoriasis Lesions on the Lower Legs.

Psoriasis is a chronic autoimmune skin disorder characterized by high morbidity and a tendency for recurrence. Although biologic therapy for lesion clearance can achieve PASI 90/100, refractory sites remain challenging to completely clear, particularly on the lower legs and elbows. To explore the efficacy of novel treatments for these resistant sites, we present a clinical observation on the safety and effectiveness of fractional carbon dioxide (CO2) laser therapy combined with secukinumab for four patients with moderate-to-severe plaque psoriasis.

Case report: Therapeutic response of front-line cadonilimab plus chemotherapy on patient with advanced lung adenocarcinoma harboring STK11 genetic aberration.

The STK11 gene mutation is a common genetic alteration in non-small cell lung cancer (NSCLC) and is significantly associated with poor responses to current immunotherapy regimens. Despite its prevalence, there is currently no established standard for front-line treatment in this subtype of NSCLC, underscoring the increasing need for personalized therapeutic strategies. In this report, we present a case of a patient with STK11-mutant NSCLC who was treated with first-line cadonilimab (10mg/kg) in combination with pemetrexed (500mg/m^2) plus carboplatin (AUC=5), resulting in a notable extension of progression-free survival (PFS).

Vitronectin promotes proliferation and metastasis of cervical cancer cells via the epithelial-mesenchymal transition.

Background: Vitronectin (VTN) is a multifunctional glycoprotein in blood and the extracellular, which could be an effective biomarker for many cancers. However, its role in cervical cancer is under investigated. In this study, we aimed to determine the molecular function of VTN and its potential mechanism in cervical cancer (CC).

CRISPR-Cas13a Targeting the FGFR3-TACC3 Fusion Gene Inhibits Proliferation of Bladder Cancer Cells in vitro and in vivo.

Introduction: The FGFR3-TACC3 fusion gene exists in a variety of malignant tumors, including bladder cancer. In our ongoing research on the CRISPR-Cas13a gene-editing system, we reported the use of CRISPR-Cas13a gene-editing system to knockout FGFR3-TACC3 and inhibit the proliferation of bladder tumor cells.

Purpose:  This study aimed to use the CRISPR-Cas13a gene-editing system to target the FGFR3-TACC3 fusion gene in bladder cancer cells, which has the potential to be a new and effective treatment for bladder cancer.

Classification and risk assessment of ovarian-adnexal lesions using parametric and radiomic analysis of co-registered ultrasound-photoacoustic tomographic images.

Ovarian-adnexal lesions are conventionally assessed with ultrasound (US) under the guidance of the Ovarian-Adnexal Reporting and Data System (O-RADS). However, the low specificity of O-RADS results in many unnecessary surgeries. Here, we use co-registered US and photoacoustic tomography (PAT) to improve the diagnostic accuracy of O-RADS.

Compulsion is associated with impaired goal-directed and habitual learning and responding in obsessive-compulsive disorder.

Background: Previous research has found that compulsions in obsessive-compulsive disorder (OCD) are associated with an imbalance between goal-directed and habitual responses. However, the cognitive mechanisms underlying how goal-directed and habitual behaviors are learned, and how these learning deficits affect the response process, remain unclear. The present study aimed to investigate these cognitive mechanisms and examine how they were involved in the mechanism of compulsions.

Inflammatory factor Interleukin-6 and its correlation with rheumatoid arthritis: A meta-analysis.

Introduction: at present, there are inconsistent research findings regarding the precise relationship between IL-6 gene polymorphisms (GPMs) and rheumatoid arthritis (RA). This work employed meta-analysis (MA) methodology to systematically evaluate the correlation between IL-6 GPMs and susceptibility to RA.

Material And Methods: this study comprehensively searched multiple databases from inception to March 31, 2024.

Serum ADAM17 levels pre-antiviral therapy correlate with HIV patient immune reconstitution.

Background: The relationship between tumour necrosis factor (TNF) levels and disease progression is well-established. However, the impact of changes in the level of TNF hydrolase (A-disintegrin and metalloenzyme 17; ADAM17) in HIV patients remains to be fully elucidated.

Methods: Between March 1 and December 31, 2017, data were collected from 64 HIV-positive individuals in Wenzhou.

Phytochemicals, promising strategies combating .

The excessive proliferation of is an important reason for the occurrence of acne vulgaris, and genetic detection ratio of in acne is as high as 60.5%. Until now, the treatment of is mainly limited to antibiotics, but some strains of produce antimicrobial resistances, making it difficult for clinical treatment.

Dysfunction and regulatory interplay of T and B cells in chronic hepatitis B: immunotherapy and emerging antiviral strategies.

In the context of chronic hepatitis B virus (HBV) infection, the continuous replication of HBV within host hepatocytes is a characteristic feature. Rather than directly causing hepatocyte destruction, this replication leads to immune dysfunction and establishes a state of T-B immune tolerance. Successful clearance of the HBV virus is dependent on the close collaboration between humoral and cellular immunity.

Roles and Mechanisms of Ferroptosis in Sorafenib Resistance for Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor, characterized by a poor prognosis. In recent decades, both the incidence and mortality rates of HCC have risen sharply. Sorafenib has emerged as the first conventional drug approved by the US Food and Drug Administration for first-line treatment in advanced HCC patients due to its favorable safety profile.