[Translated article] Consensus recommendations on the preventive treatment of migraine.

Objective: The objectives are to know the opinion of neurologists and hospital pharmacists on those aspects still under debate regarding the role of anti-Calcitonin Gene-related Peptide monoclonal antibodies in the preventive treatment of migraine. To identify those controversies that still exist. To propose agreed recommendations for improvement of care.

Consensus recommendations for the treatment of migraine prevention.

Objective: The objectives are to know the opinion of neurologists and hospital pharmacists on those aspects still under debate regarding the role of anti-CGRP monoclonal antibodies in the preventive treatment of migraine. To identify those controversies that still exist. To propose agreed recommendations for improvement of care.

[Rituximab for the treatment of generalised myasthenia gravis: experience in clinical practice].

Introduction And Aims: Rituximab (RTX) is an anti-CD20 monoclonal antibody that has been used in cases of refractory myasthenia gravis (MG). The aim of this work is to analyse the efficacy and safety of RTX in MG in real clinical practice in a tertiary hospital.

Patients And Methods: A retrospective study was conducted with patients with MG treated with RTX in our centre from March 2014 to September 2020.

1st Post-European Headache Federation Meeting: a review of the latest developments presented at the 2020 European Headache Federation Congress.

Introduction: After the European Headache Federation (EHF) Congress, renowned Spanish neurologists specialised in migraine presented the most significant latest developments in research in this field at the Post-EHF Meeting.

Development: The main data presented concerning the treatment of chronic and episodic migraine were addressed, with attention paid more specifically to those related to preventive treatments and real-life experience in the management of the disease. An important review was carried out of the new therapeutic targets and the possibilities they offer in terms of understanding the pathophysiology of migraine and its treatment.

[Impact of the COVID-19 pandemic on the training of Spanish neurology residents].

Introduction: The COVID-19 pandemic has transformed medical practice and severely disrupted the training of medical residents worldwide. The Spanish Society of Neurology conducted a study to assess its impact on the training of neurology residents in Spain.

Methods: We performed a descriptive, cross-sectional study through a survey distributed by e-mail to all neurology residents belonging to the Society.

Will neurological care change over the next 5 years due to the COVID-19 pandemic? Key informant consensus survey.

Introduction: The COVID-19 pandemic will give rise to long-term changes in neurological care, which are not easily predictable.

Material And Methods: A key informant survey was used to enquire about the changes expected in the specialty over the next 5 years. The survey was completed by heads of neurology departments with broad knowledge of the situation, having been active during the pandemic.

[«Apuntes en Neurologia» (Notes in Neurology): a synthesis of the evidence on common paroxysmal neurological disorders and on neurodegenerative disorders].

«Apuntes en Neurologia» is an initiative in which prominent national and international leaders, with broad academic recognition, came together to synthesise the most outstanding clinical aspects within their area of interest and to discuss the latest developments in a more accessible language. Understanding the factors that affect the onset and progression of any neurological disease through a review is important to be able to develop strategies to reduce the burden of these diseases. Moreover, knowledge of the clinical aspects is essential to solve the problems of daily clinical practice.

[Therapeutic plasma exchange: applications in neurology].

Introduction: Plasma exchange is a technique used in the treatment of some neurological autoimmune disorders since the 80s, especially in acute conditions. In recent years new data about it use has been published in many diseases with autoimmune basis, expanding the range of use of this technique.

Aim: To update the current indications of this technique in the treatment of neurological diseases.

[Triptans in clinical practice: effectiveness, tolerance and patient's satisfaction with medication (TRIPRACLI study)].

Introduction And Aims: This study was aimed determining the effectiveness, tolerance and satisfaction of patients with migraine as regards different triptans, according to the characteristics of their attacks. At the same time it sought to establish a predictive model that can be used to recommend one or another, depending on those characteristics.

Patients And Methods: Retrospective observation-based study conducted in headache units in a number of different centres.

[Onabotulinumtoxin A in the treatment of chronic migraine].

INTRODUCTION. Chronic migraine is the most frequent complication of migraine. Its management is complex and difficult, and is based essentially on preventive measures.

[Chronic migraine as seen by neurologists and patients: results of the CIEN-mig project (III)].

Introduction: Data on the reality of chronic migraine in our clinics are scarce. AIM. To know the frequency of consultation and attitude of the neurologist regarding chronic migraine, and the opinion of patients with this condition.

[Satisfaction of the migraine patient attending neurology clinics: results of CIEN-mig project (II)].

Introduction: Migraine is the most common neurological consultation in our country. AIM. To analyse the satisfaction level of the patient with migraine attending our clinics.

[Approach of neurologists in Spain to migraine: results of the CIEN-mig project (I)].

Introduction: Headache is the most frequent neurological reason for consultation in our country.

Aim: To obtain descriptive data on the approach and satisfaction of the neurologist regarding the diagnosis, burden and management of headaches, and migraine in particular, together with the relationship with primary care physicians (PCP).

Subjects And Methods: A total of 160 neurologists participated and answered electronically five questionnaires during one year.

[Preventive treatment of chronic migraine with zonisamide: a study in patients who are refractory or intolerant to topiramate].

Introduction: About half of the patients with chronic migraine do not respond or do not tolerate the different migraine preventatives.

Aim: To analyse the efficacy and tolerability of zonisamide in the treatment of migraine in patients who had not responded or tolerated topiramate, the current drug of choice for the treatment of this condition.

Patients And Methods: Those patients with no response or intolerance to topiramate received zonisamide.

[Silent microhemorrhages in patients with symptomatic cerebrovascular disease].

Introduction: T2*-weighted gradient echo MRI sequences (T2*-MRI) have made it possible to detect cerebral microhemorrhages (MH) that have been considered as subclinical but whose clinical significance is largely unknown.

Objective: To establish the frequency of MH in a sample of consecutive symptomatic cerebrovascular disease (SCD) patients, analyzing its associations with different vascular risk factors (VRF) and its clinical significance.

Methods: A total of 198 patients with SCD were consecutively examined using T2*-MRI.

[Atypical clinicoradiological course in a case panancephalic variant of Creutzfeldt-Jakob].

Introduction: Creutzfeldt-Jakob disease (CJD) is the most frequent of the human transmissible spongiform encephalopathies. Pathogenic mechanisms of CJD are still unknown. Sporadic CJD, the most habitual, is clinically characterized by rapidly progressive dementia, myoclonia and ataxia.

[Subacute uveomeningoencephalitis as the presenting symptom of acute infection by the human immunodeficiency virus].

Introduction: The uveo-meningitic syndrome, or the combination of chronic or recurrent meningitis and acute uveitis, has a specific differential diagnosis. This syndrome can be the clinical debut of systemic disorders, vasculophathies, connective tissue disorders and inmuno-mediated diseases. In patients with AIDS, the syndrome often appears in relation with an opportunist concomitant infection of the central nervous system (CNS).

[Management costs of chest and CNS-related adverse events associated with the treatment of acute migraine attacks with oral triptans].

Introduction: Although adverse events of triptans are usually not important from a clinical point of view, they can worry patients and lead them to consume healthcare resources.

Methods: A decision analytic model was used to represent the behavior and management of patients who suffered adverse events after taking a triptan. Using data about the incidence of adverse events, the behavior and management of patients, and the unit cost of the healthcare resource consumed, the costs of treating adverse events were calculated, as was the iatrogenic cost factor of the triptans available in Spain.

[Posttraumatic headache. Pathophysiology, clinical, diagnostic and therapeutic aspects].

Posttraumatic headache (PTHA) is, usually, one of several symptoms of the posttraumatic syndrome and therefore may be accompanied by somatic, psychological or cognitive disturbances. The aetiology of these symptoms in individuals with mild traumatic brain injury or whiplash injury has been a subject of some controversy with explanations ranging from neural damage to malingering. PTHA can resemble a tension-type headache, migrainous or cervicogenic headaches.

[Efficacy and safety of endovascular treatment of brain aneurysms: experience in our setting].

Introduction: The objective of our study is to know the efficacy and safety of endovascular treatment in our setting.

Patients And Methods: a) prospective evaluation of patients with aneurysmal subarachnoid hemorrhage (SAH) or incidental aneurysm (Dec 1999-Dec 2002), and b) neurological, angiographic and evolutive evaluation of the endovascularly operated patients.

Results: A total of 79 patients were evaluated: 75 with SAH, 4 with incidental aneurysm.