Publications by authors named "Laine Feller"

Article Synopsis
  • Skin colonization and eosinophil infiltration are linked to several inflammatory skin disorders, but the role of eosinophils in skin inflammation is not fully understood.
  • A mouse model study showed that exposure to certain conditions increased eosinophil-recruiting chemokines and led to notable eosinophil infiltration, contributing significantly to skin inflammation alongside T cells.
  • The research identified that IL-36R signaling and proteases are critical in this process, as they promote the recruitment of eosinophils producing IL-17, revealing new insights into how skin inflammation develops in various skin diseases.
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Article Synopsis
  • - Pyrazinamide (PZA) is a key antibiotic in tuberculosis (TB) treatment that, while not very effective at killing bacteria, significantly shortens treatment duration and has anti-inflammatory properties.
  • - The study identifies Poly(ADP-ribose) Polymerase 1 (PARP1) as a crucial target of PZA, revealing that PZA inhibits PARP1 activity in TB-affected macrophages and mice, which is linked to its immune-modulating effects rather than its bactericidal effects.
  • - The research suggests that inhibiting PARP1 not only reduces lung inflammation and damage but may also enhance the overall effectiveness of TB treatment, highlighting a new therapeutic approach to improve patient outcomes.
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Background: Obesity in common marmosets (Callithrix jacchus) can lead to various liver pathologies. In other species, reduced caloric intake and weight loss improve prognosis, and, often, hepatoprotectants are used to halt or reverse hepatocellular damage from fat deposition in the liver. There are no published therapies for reducing hepatocellular damage in obese marmosets.

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The interactions between immune cells and epithelial cells influence the progression of many respiratory diseases, such as chronic obstructive pulmonary disease (COPD). In vitro models allow for the examination of cells in controlled environments. However, these models lack the complex 3D architecture and vast multicellular interactions between the lung resident cells and infiltrating immune cells that can mediate cellular response to insults.

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Article Synopsis
  • Göttingen minipigs are being used more often as a large animal model in toxicology studies, and finding serious lesions in them is uncommon.
  • The report describes four cases of cardiac rhabdomyoma, a benign heart mass, with some cases showing no visible abnormalities during gross examination.
  • Microscopic analysis revealed specific cell characteristics in the nodules, but there was no indication that these masses caused any heart function issues, marking this as the first report of such tumors in Göttingen minipigs.
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