Publications by authors named "Laila Salome Araujo de Souza"
Bioorg Med Chem Lett
June 2015
Article Synopsis
- - Malaria remains a significant global health issue, complicated by widespread drug resistance, necessitating the search for new antimalarial compounds.
- - This study tested 10 synthetic compounds derived from quinoline, assessing their effectiveness against both drug-sensitive and resistant strains of Plasmodium falciparum, while ensuring minimal cytotoxicity to human cell lines.
- - Among the tested compounds, the hydrazine derivative 1f showed promising antimalarial activity, with a high selectivity index and effectiveness in mice, making it a prime candidate for future research in malaria treatment.
